Search Results - "Phillips, Don"

Mitoxantrone, More than Just Another Topoisomerase II Poison by Evison, Benny J., Sleebs, Brad E., Watson, Keith G., Phillips, Don R., Cutts, Suzanne M.

“…Mitoxantrone is a synthetic anthracenedione originally developed to improve the therapeutic profile of the anthracyclines and is commonly applied in the…”
Get full text

Factors determining the stability, size distribution, and cellular accumulation of small, monodisperse chitosan nanoparticles as candidate vectors for anticancer drug delivery: application to the passive encapsulation of [(14)C]-doxorubicin by Masarudin, Mas Jaffri, Cutts, Suzanne M, Evison, Benny J, Phillips, Don R, Pigram, Paul J

“…Development of parameters for the fabrication of nanosized vectors is pivotal for its successful administration in therapeutic applications. In this study,…”
Get full text

Understanding mass spectrometry images: complexity to clarity with machine learning by Gardner, Wil, Cutts, Suzanne M., Phillips, Don R., Pigram, Paul J.

“…The application of artificial intelligence and machine learning to hyperspectral mass spectrometry imaging (MSI) data has received considerable attention over…”
Get full text

Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent by Cutts, Suzanne M, Rephaeli, Ada, Nudelman, Abraham, Ugarenko, Michal, Phillips, Don R

“…Doxorubicin has been in use as a key anticancer drug for forty years, either as a single agent or in combination chemotherapy. It functions primarily by…”
Get more information

Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death by SWIFT, Lonnie P, REPHAELI, Ada, NUDELMAN, Abraham, PHILLIPS, Don R, CUTTS, Suzanne M

“…Doxorubicin (Adriamycin) is one of the most commonly used chemotherapeutic drugs and exhibits a wide spectrum of activity against solid tumors, lymphomas, and…”
Get full text

An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells by Mansour, Oula C., Nudelman, Abraham, Rephaeli, Ada, Phillips, Don R., Cutts, Suzanne M., Evison, Benny J.

“…Purpose Pixantrone is a synthetic aza-anthracenedione currently used in the treatment of non-Hodgkin’s lymphoma. The drug is firmly established as a poison of…”
Get full text

Development of an automated assay for accelerated in vitro detection of DNA adduct-inducing and crosslinking agents by Medan, Jelena, Sleebs, Brad E., Lackovic, Kurt, Watson, Keith G., Evison, Benny J., Phillips, Don R., Cutts, Suzanne M.

“…[Display omitted] Current techniques for the identification of DNA adduct-inducing and DNA interstrand crosslinking agents include electrophoretic crosslinking…”
Get full text

Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation by Forrest, Robert A., Swift, Lonnie P., Rephaeli, Ada, Nudelman, Abraham, Kimura, Ken-Ichi, Phillips, Don R., Cutts, Suzanne M.

“…The cytotoxicity of doxorubicin, a clinically used anti-neoplastic drug, can be enhanced by formaldehyde (either endogenous or exogenous) to promote the…”
Get full text

Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor by Tarasenko, Nataly, Cutts, Suzanne M, Phillips, Don R, Inbal, Aida, Nudelman, Abraham, Kessler-Icekson, Gania, Rephaeli, Ada

“…The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) synergizes the cytotoxic effect of doxorubicin (Dox) and anti-HER2 on…”
Get full text

Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features by Pumuye, Paul P., Evison, Benny J., Konda, Shyam K., Collins, J. Grant, Kelso, Celine, Medan, Jelena, Sleebs, Brad E., Watson, Keith, Phillips, Don R., Cutts, Suzanne M.

“…[Display omitted] Mitoxantrone is an anticancer anthracenedione that can be activated by formaldehyde to generate covalent drug-DNA adducts. Despite their…”
Get full text

A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo by Tarasenko, Nataly, Cutts, Suzanne M., Phillips, Don R., Berkovitch-Luria, Gili, Bardugo-Nissim, Elinor, Weitman, Michal, Nudelman, Abraham, Rephaeli, Ada

“…The poor survival of patients with malignant gliomas, underscores the need to develop effective treatment modalities for this devastating disease. Epigenetic…”
Get full text

Encapsulation of Mitoxantrone within Cucurbit[8]uril Decreases Toxicity and Enhances Survival in a Mouse Model of Cancer by Konda, Shyam K, Maliki, Ruqaya, McGrath, Sean, Parker, Belinda S, Robinson, Tina, Spurling, Alex, Cheong, Alison, Lock, Peter, Pigram, Paul J, Phillips, Don R, Wallace, Lynne, Day, Anthony I, Collins, J. Grant, Cutts, Suzanne M

“…Mitoxantrone was efficiently encapsulated within cucurbit[8]­uril in a 2:1 complex where the two mitoxantrone molecules were symmetrically located through both…”
Get full text

The Power and Potential of Doxorubicin‐DNA Adducts by Cutts, Suzanne M., Nudelman, Abraham, Rephaeli, Ada, Phillips, Don R.

“…Doxorubicin (trade name Adriamycin) is a widely used anticancer agent which exhibits good activity against a wide range of tumors. Although the major mode of…”
Get full text

Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations by Coldwell, Kate E, Cutts, Suzanne M, Ognibene, Ted J, Henderson, Paul T, Phillips, Don R

“…Limited sensitivity of existing assays has prevented investigation of whether Adriamycin-DNA adducts are involved in the anti-tumour potential of Adriamycin…”
Get full text

Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major-minor groove cross-linked adducts by Konda, Shyam K, Kelso, Celine, Medan, Jelena, Sleebs, Brad E, Phillips, Don R, Cutts, Suzanne M, Collins, J Grant

“…The major covalent adduct formed between a C-labelled formaldehyde activated bis-amino mitoxantrone analogue (WEHI-150) and the hexanucleotide d(CG CGCG) has…”
Get more information

Binding of pixantrone to DNA at CpA dinucleotide sequences and bulge structures by Konda, Shyam K, Wang, Haiqiang, Cutts, Suzanne M, Phillips, Don R, Collins, J Grant

“…The binding of the anti-cancer drug pixantrone to three oligonucleotide sequences, d(TCATATGA)2, d(CCGAGAATTCCGG)2 {double bulge = DB} and the non-self…”
Get more information

The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity by Tarasenko, Nataly, Kessler-Icekson, Gania, Boer, Pnina, Inbal, Aida, Schlesinger, Hadassa, Phillips, Don R., Cutts, Suzanne M., Nudelman, Abraham, Rephaeli, Ada

“…Summary The histone deacetylase inhibitor (HDACI) butyroyloxymethyl diethylphosphate (AN-7) has been shown to synergize doxorubicin (Dox) anticancer activity…”
Get full text

Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA by Konda, Shyam K, Kelso, Celine, Pumuye, Paul P, Medan, Jelena, Sleebs, Brad E, Cutts, Suzanne M, Phillips, Don R, Collins, J Grant

“…The ability of a bis-amino mitoxantrone anticancer drug (named WEHI-150) to form covalent adducts with DNA, after activation by formaldehyde, has been studied…”
Get more information

Design, synthesis, and DNA sequence selectivity of formaldehyde-mediated DNA-adducts of the novel N-(4-aminobutyl) acridine-4-carboxamide by Ankers, Elizabeth A, Evison, Benny J, Phillips, Don R, Brownlee, Robert T C, Cutts, Suzanne M

“…A novel derivative of the anti-tumor agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) was prepared by reduction of 9-oxoacridan-4-carboxylic acid…”
Get full text

Operational efficiency and effectiveness measurement by Jeong, Ki-Young, Phillips, Don T.

“…The accurate estimation of equipment utilization is very important in capital-intensive industry since the identification and analysis of hidden time losses…”
Get full text