Search Results - "Phillips, Ben P"

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly by Baker, Richard W., Jeffrey, Philip D., Zick, Michael, Phillips, Ben P., Wickner, William T., Hughson, Frederick M.

“…Fusion of intracellular transport vesicles requires soluble N-ethylmaleimide–sensitive factor attachment protein receptors (SNAREs) and Sec1/Munc18-family (SM)…”
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The architecture of EMC reveals a path for membrane protein insertion by O'Donnell, John P, Phillips, Ben P, Yagita, Yuichi, Juszkiewicz, Szymon, Wagner, Armin, Malinverni, Duccio, Keenan, Robert J, Miller, Elizabeth A, Hegde, Ramanujan S

“…Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved…”
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Pre-emptive Quality Control of a Misfolded Membrane Protein by Ribosome-Driven Effects by Lakshminarayan, Ramya, Phillips, Ben P., Binnian, Imogen L., Gomez-Navarro, Natalia, Escudero-Urquijo, Norberto, Warren, Alan J., Miller, Elizabeth A.

“…Cells possess multiple mechanisms that protect against the accumulation of toxic aggregation-prone proteins. Here, we identify a pre-emptive pathway that…”
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Structural basis of TRAPPIII‐mediated Rab1 activation by Joiner, Aaron MN, Phillips, Ben P, Yugandhar, Kumar, Sanford, Ethan J, Smolka, Marcus B, Yu, Haiyuan, Miller, Elizabeth A, Fromme, J Christopher

“…The GTPase Rab1 is a master regulator of the early secretory pathway and is critical for autophagy. Rab1 activation is controlled by its guanine nucleotide…”
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Evolutionary balance between foldability and functionality of a glucose transporter by Choi, Hyun-Kyu, Kang, Hyunook, Lee, Chanwoo, Kim, Hyun Gyu, Phillips, Ben P., Park, Soohyung, Tumescheit, Charlotte, Kim, Sang Ah, Lee, Hansol, Roh, Soung-Hun, Hong, Heedeok, Steinegger, Martin, Im, Wonpil, Miller, Elizabeth A., Choi, Hee-Jung, Yoon, Tae-Young

“…Despite advances in resolving the structures of multi-pass membrane proteins, little is known about the native folding pathways of these complex structures…”
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Protein quality control in the endoplasmic reticulum by Phillips, Ben P., Gomez-Navarro, Natalia, Miller, Elizabeth A.

“…Misfolded and mistargeted proteins in the early secretory pathway present significant risks to the cell. A diverse and integrated network of quality control…”
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Membrane protein folding and quality control by Phillips, Ben P., Miller, Elizabeth A.

“…Membrane proteins account for a quarter of cellular proteins, and most are synthesised at the endoplasmic reticulum (ER). Insertion and folding of polypeptides…”
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Ribosome-associated quality control of membrane proteins at the endoplasmic reticulum by Phillips, Ben P, Miller, Elizabeth A

“…Protein synthesis is an energetically costly, complex and risky process. Aberrant protein biogenesis can result in cellular toxicity and disease, with…”
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Structure of ATP synthase from ESKAPE pathogen Acinetobacter baumannii by Demmer, Julius K, Phillips, Ben P, Uhrig, O Lisa, Filloux, Alain, Allsopp, Luke P, Bublitz, Maike, Meier, Thomas

“…The global spread of multidrug-resistant infections urgently calls for the identification of novel drug targets. We solved the electron cryo-microscopy…”
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