Search Results - "Phillips, Angela M"

Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1 by Moulana, Alief, Dupic, Thomas, Phillips, Angela M., Chang, Jeffrey, Nieves, Serafina, Roffler, Anne A., Greaney, Allison J., Starr, Tyler N., Bloom, Jesse D., Desai, Michael M.

“…The Omicron BA.1 variant emerged in late 2021 and quickly spread across the world. Compared to the earlier SARS-CoV-2 variants, BA.1 has many mutations, some…”
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Quantifying Drosophila food intake: comparative analysis of current methodology by Deshpande, Sonali A, Carvalho, Gil B, Amador, Ariadna, Phillips, Angela M, Hoxha, Sany, Lizotte, Keith J, Ja, William W

“…This Analysis compares four commonly used assays to measure food intake in flies and identifies radioisotope-labeling and the capillary feeder (CAFE) as the…”
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The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution by Moulana, Alief, Dupic, Thomas, Phillips, Angela M, Chang, Jeffrey, Roffler, Anne A, Greaney, Allison J, Starr, Tyler N, Bloom, Jesse D, Desai, Michael M

“…The Omicron BA.1 variant of SARS-CoV-2 escapes convalescent sera and monoclonal antibodies that are effective against earlier strains of the virus. This immune…”
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Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors by Zhou, Lei, Lovell, Kimberly M., Frankowski, Kevin J., Slauson, Stephen R., Phillips, Angela M., Streicher, John M., Stahl, Edward, Schmid, Cullen L., Hodder, Peter, Madoux, Franck, Cameron, Michael D., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.

“…The kappa opioid receptor (KOR) is widely expressed in the CNS and can serve as a means to modulate pain perception, stress responses, and affective reward…”
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Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations by Johnson, Milo S, Gopalakrishnan, Shreyas, Goyal, Juhee, Dillingham, Megan E, Bakerlee, Christopher W, Humphrey, Parris T, Jagdish, Tanush, Jerison, Elizabeth R, Kosheleva, Katya, Lawrence, Katherine R, Min, Jiseon, Moulana, Alief, Phillips, Angela M, Piper, Julia C, Purkanti, Ramya, Rego-Costa, Artur, McDonald, Michael J, Nguyen Ba, Alex N, Desai, Michael M

“…Laboratory experimental evolution provides a window into the details of the evolutionary process. To investigate the consequences of long-term adaptation, we…”
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Hierarchical sequence-affinity landscapes shape the evolution of breadth in an anti-influenza receptor binding site antibody by Phillips, Angela M, Maurer, Daniel P, Brooks, Caelan, Dupic, Thomas, Schmidt, Aaron G, Desai, Michael M

“…Broadly neutralizing antibodies (bnAbs) that neutralize diverse variants of a particular virus are of considerable therapeutic interest. Recent advances have…”
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Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies by Phillips, Angela M, Lawrence, Katherine R, Moulana, Alief, Dupic, Thomas, Chang, Jeffrey, Johnson, Milo S, Cvijovic, Ivana, Mora, Thierry, Walczak, Aleksandra M, Desai, Michael M

“…Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer protection against diverse influenza strains have been isolated…”
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Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations by Bakerlee, Christopher W, Phillips, Angela M, Nguyen Ba, Alex N, Desai, Michael M

“…Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other…”
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Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones by Phillips, Angela M, Ponomarenko, Anna I, Chen, Kenny, Ashenberg, Orr, Miao, Jiayuan, McHugh, Sean M, Butty, Vincent L, Whittaker, Charles A, Moore, Christopher L, Bloom, Jesse D, Lin, Yu-Shan, Shoulders, Matthew D

“…The threat of viral pandemics demands a comprehensive understanding of evolution at the host-pathogen interface. Here, we show that the accessibility of…”
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Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin by Phillips, Angela M, Doud, Michael B, Gonzalez, Luna O, Butty, Vincent L, Lin, Yu-Shan, Bloom, Jesse D, Shoulders, Matthew D

“…We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway…”
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The genetic basis of differential autodiploidization in evolving yeast populations by Tung, Sudipta, Bakerlee, Christopher W, Phillips, Angela M, Nguyen Ba, Alex N, Desai, Michael M

“…Spontaneous whole-genome duplication, or autodiploidization, is a common route to adaptation in experimental evolution of haploid budding yeast populations…”
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Host proteostasis modulates influenza evolution by Phillips, Angela M, Gonzalez, Luna O, Nekongo, Emmanuel E, Ponomarenko, Anna I, McHugh, Sean M, Butty, Vincent L, Levine, Stuart S, Lin, Yu-Shan, Mirny, Leonid A, Shoulders, Matthew D

“…Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens…”
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Genotype–phenotype landscapes for immune–pathogen coevolution by Moulana, Alief, Dupic, Thomas, Phillips, Angela M., Desai, Michael M.

“…The set of all possible pathogen and immune receptor sequences, along with the phenotypes that define their fitness and interactions, define a large and…”
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The Path of Least Resistance: Mechanisms to Reduce Influenza's Sensitivity to Oseltamivir by Phillips, Angela M., Shoulders, Matthew D.

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The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope by Yoon, Jimin, Nekongo, Emmanuel E, Patrick, Jessica E, Hui, Tiffani, Phillips, Angela M, Ponomarenko, Anna I, Hendel, Samuel J, Sebastian, Rebecca M, Zhang, Yu Meng, Butty, Vincent L, Ogbunugafor, C Brandon, Lin, Yu-Shan, Shoulders, Matthew D

“…The sequence space accessible to evolving proteins can be enhanced by cellular chaperones that assist biophysically defective clients in navigating complex…”
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Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif by Frankowski, Kevin J., Slauson, Stephen R., Lovell, Kimberly M., Phillips, Angela M., Streicher, John M., Zhou, Lei, Whipple, David A., Schoenen, Frank J., Prisinzano, Thomas E., Bohn, Laura M., Aubé, Jeffrey

“…[Display omitted] Optimization of the sulfonamide-based kappa opioid receptor (KOR) antagonist probe molecule ML140 through constraint of the sulfonamide…”
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Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies by Gyanda, Reena, Banerjee, Jayati, Chang, Yi-Pin, Phillips, Angela M., Toll, Lawrence, Armishaw, Christopher J.

“…α‐Conotoxins are peptide neurotoxins that selectively inhibit various subtypes of nicotinic acetylcholine receptors. They are important research tools for…”
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Vitamin D-dependent non-type 1, non-type 2 rickets in a 3-month-old Cornish Rex kitten by Phillips, Angela M., Fawcett, Anne C., Allan, Graeme S., Wilkinson, Margaret, Fraser, David R., Malik, Richard

“…A 3-month-old female Cornish Rex kitten was found to have non-painful swelling of the carpal and tarsal regions when presented for routine neutering. The…”
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Oxidative folding and preparation of [alpha]-conotoxins for use in high-throughput structure-activity relationship studies by Gyanda, Reena, Banerjee, Jayati, Chang, Yi-Pin, Phillips, Angela M, Toll, Lawrence, Armishaw, Christopher J

“…[alpha]-Conotoxins are peptide neurotoxins that selectively inhibit various subtypes of nicotinic acetylcholine receptors. They are important research tools…”
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Retrospective Analysis of Direct-Acting Oral Anticoagulants (DOACs) Initiation Timing and Outcomes After Thrombolysis in High- and Intermediate-Risk Pulmonary Embolism by Wolfe, Adam, Phillips, Angela, Tierney, David M, Melamed, Roman, Qadri, Ghazi, Lillyblad, Matthew, Smith, Claire, St. Hill, Catherine, Stenzel, Ashley E, Beddow, David, Kirven, Justin, Kethireddy, Rajesh, Patel, Love

“…Direct-acting oral anticoagulants (DOACs) are prescribed in the treatment of venous thromboembolism, including pulmonary embolism (PE). Evidence is limited…”
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