Search Results - "Phillip, Jude M"

The Mechanobiology of Aging by Phillip, Jude M, Aifuwa, Ivie, Walston, Jeremy, Wirtz, Denis

“…Aging is a complex, multifaceted process that induces a myriad of physiological changes over an extended period of time. Aging is accompanied by major…”
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Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures by Kotlov, Nikita, Bagaev, Alexander, Revuelta, Maria V, Phillip, Jude M, Cacciapuoti, Maria Teresa, Antysheva, Zoya, Svekolkin, Viktor, Tikhonova, Ekaterina, Miheecheva, Natalia, Kuzkina, Natalia, Nos, Grigorii, Tabbo, Fabrizio, Frenkel, Felix, Ghione, Paola, Tsiper, Maria, Almog, Nava, Fowler, Nathan, Melnick, Ari M, Leonard, John P, Inghirami, Giorgio, Cerchietti, Leandro

“…Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Transcriptomic and genetic characterization of DLBCL has…”
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Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules by Yu, Yu, Gaillard, Stephanie, Phillip, Jude M., Huang, Tai-Chung, Pinto, Sneha M., Tessarollo, Nayara G., Zhang, Zhen, Pandey, Akhilesh, Wirtz, Denis, Ayhan, Ayse, Davidson, Ben, Wang, Tian-Li, Shih, Ie-Ming

“…Resistance to chemotherapy represents a major obstacle for long-term remission, and effective strategies to overcome drug resistance would have significant…”
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Use of the p-values as a size-dependent function to address practical differences when analyzing large datasets by Gómez-de-Mariscal, Estibaliz, Guerrero, Vanesa, Sneider, Alexandra, Jayatilaka, Hasini, Phillip, Jude M., Wirtz, Denis, Muñoz-Barrutia, Arrate

“…Biomedical research has come to rely on p-values as a deterministic measure for data-driven decision-making. In the largely extended null hypothesis…”
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TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate by Venturutti, Leandro, Teater, Matt, Zhai, Andrew, Chadburn, Amy, Babiker, Leena, Kim, Daleum, Béguelin, Wendy, Lee, Tak C., Kim, Youngjun, Chin, Christopher R., Yewdell, William T., Raught, Brian, Phillip, Jude M., Jiang, Yanwen, Staudt, Louis M., Green, Michael R., Chaudhuri, Jayanta, Elemento, Olivier, Farinha, Pedro, Weng, Andrew P., Nissen, Michael D., Steidl, Christian, Morin, Ryan D., Scott, David W., Privé, Gilbert G., Melnick, Ari M.

“…The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry somatic mutations in the poorly characterized gene TBL1XR1. Here, we…”
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Epigenetic reprogramming sensitizes immunologically silent EBV+ lymphomas to virus-directed immunotherapy by Dalton, Tanner, Doubrovina, Ekaterina, Pankov, Dmitry, Reynolds, Raymond, Scholze, Hanna, Selvakumar, Annamalai, Vizconde, Teresa, Savalia, Bhumesh, Dyomin, Vadim, Weigel, Christoph, Oakes, Christopher C., Alonso, Alicia, Elemento, Olivier, Pan, Heng, Phillip, Jude M., O'Reilly, Richard J., Gewurz, Benjamin E., Cesarman, Ethel, Giulino-Roth, Lisa

“…Despite advances in T-cell immunotherapy against Epstein-Barr virus (EBV)-infected lymphomas that express the full EBV latency III program, a critical barrier…”
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EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3‐dimensional cell migration by Jayatilaka, Hasini, Giri, Anjil, Karl, Michelle, Aifuwa, Ivie, Trenton, Nicholaus J., Phillip, Jude M., Khatau, Shyam, Wirtz, Denis

“…Microtubules have long been implicated to play an integral role in metastatic disease, for which a critical step is the local invasion of tumor cells into the…”
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Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma by Clauzure, Mariángeles, Táquez Delgado, Mónica A, Phillip, Jude M, Revuelta, Maria V, Cerchietti, Leandro, Medina, Vanina A

“…The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of the role of histamine in numerous physiological and pathological…”
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Volume regulation and shape bifurcation in the cell nucleus by Kim, Dong-Hwee, Li, Bo, Si, Fangwei, Phillip, Jude M, Wirtz, Denis, Sun, Sean X

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Profiling Dynamic Patterns of Single‐Cell Motility by Maity, Debonil, Sivakumar, Nikita, Kamat, Pratik, Zamponi, Nahuel, Min, Chanhong, Du, Wenxuan, Jayatilaka, Hasini, Johnston, Adrian, Starich, Bartholomew, Agrawal, Anshika, Riley, Deanna, Venturutti, Leandro, Melnick, Ari, Cerchietti, Leandro, Walston, Jeremy, Phillip, Jude M.

“…Cell motility plays an essential role in many biological processes as cells move and interact within their local microenvironments. Current methods for…”
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Biophysical and biomolecular determination of cellular age in humans by Phillip, Jude M., Wu, Pei-Hsun, Gilkes, Daniele M., Williams, Wadsworth, McGovern, Shaun, Daya, Jena, Chen, Jonathan, Aifuwa, Ivie, Lee, Jerry S. H., Fan, Rong, Walston, Jeremy, Wirtz, Denis

“…Ageing research has focused either on assessing organ- and tissue-based changes, such as lung capacity and cardiac function, or on changes at the molecular…”
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Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway by Pera, Benet, Krumsiek, Jan, Assouline, Sarit E., Marullo, Rossella, Patel, Jayeshkumar, Phillip, Jude M., Román, Lidia, Mann, Koren K., Cerchietti, Leandro

“…Despite the proven clinical antineoplastic activity of histone deacetylase inhibitors (HDACI), their effect has been reported to be lower than expected in…”
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Fractional re-distribution among cell motility states during ageing by Phillip, Jude M., Zamponi, Nahuel, Phillip, Madonna P., Daya, Jena, McGovern, Shaun, Williams, Wadsworth, Tschudi, Katherine, Jayatilaka, Hasini, Wu, Pei-Hsun, Walston, Jeremy, Wirtz, Denis

“…Ageing in humans is associated with the decreased capacity to regulate cell physiology. Cellular properties, such as cell morphology and mechanics, encode…”
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A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei by Phillip, Jude M., Han, Kyu-Sang, Chen, Wei-Chiang, Wirtz, Denis, Wu, Pei-Hsun

“…Cell morphology encodes essential information on many underlying biological processes. It is commonly used by clinicians and researchers in the study,…”
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Quantitative morphological analysis of Deinococcus radiodurans elucidates complex dose-dependent nucleoid condensation during recovery from ionizing radiation by Cordova, Antonio, Niese, Brandon, Sweet, Philip, Kamat, Pratik, Phillip, Jude M, Gordon, Vernita, Contreras, Lydia M

“…The extremophile maintains a highly organized and condensed nucleoid as its default state, possibly contributing to its high tolerance to ionizing radiation…”
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Functional interplay between the cell cycle and cell phenotypes by Chen, Wei-Chiang, Wu, Pei-Hsun, Phillip, Jude M, Khatau, Shyam B, Choi, Jae Min, Dallas, Matthew R, Konstantopoulos, Konstantinos, Sun, Sean X, Lee, Jerry S H, Hodzic, Didier, Wirtz, Denis

“…Cell cycle distribution of adherent cells is typically assessed using flow cytometry, which precludes the measurements of many cell properties and their cycle…”
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Deep learning identification of stiffness markers in breast cancer by Sneider, Alexandra, Kiemen, Ashley, Kim, Joo Ho, Wu, Pei-Hsun, Habibi, Mehran, White, Marissa, Phillip, Jude M., Gu, Luo, Wirtz, Denis

“…While essential to our understanding of solid tumor progression, the study of cell and tissue mechanics has yet to find traction in the clinic. Determining…”
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Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response by Béguelin, Wendy, Teater, Matt, Meydan, Cem, Hoehn, Kenneth B., Phillip, Jude M., Soshnev, Alexey A., Venturutti, Leandro, Rivas, Martín A., Calvo-Fernández, María T., Gutierrez, Johana, Camarillo, Jeannie M., Takata, Katsuyoshi, Tarte, Karin, Kelleher, Neil L., Steidl, Christian, Mason, Christopher E., Elemento, Olivier, Allis, C. David, Kleinstein, Steven H., Melnick, Ari M.

“…Follicular lymphomas (FLs) are slow-growing, indolent tumors containing extensive follicular dendritic cell (FDC) networks and recurrent EZH2 gain-of-function…”
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Volume regulation and shape bifurcation in the cell nucleus by Kim, Dong-Hwee, Li, Bo, Si, Fangwei, Phillip, Jude M, Wirtz, Denis, Sun, Sean X

“…Alterations in nuclear morphology are closely associated with essential cell functions, such as cell motility and polarization, and correlate with a wide range…”
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Single-cell morphology encodes metastatic potential by Wu, Pei-Hsun, Gilkes, Daniele M, Phillip, Jude M, Narkar, Akshay, Cheng, Thomas Wen-Tao, Marchand, Jorge, Lee, Meng-Horng, Li, Rong, Wirtz, Denis

“…A central goal of precision medicine is to predict disease outcomes and design treatments based on multidimensional information from afflicted cells and…”
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