Search Results - "Philips, Rachael L"

The JAK-STAT pathway at 30: Much learned, much more to do by Philips, Rachael L., Wang, Yuxin, Cheon, HyeonJoo, Kanno, Yuka, Gadina, Massimo, Sartorelli, Vittorio, Horvath, Curt M., Darnell, James E., Stark, George R., O’Shea, John J.

“…The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to…”
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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23 by Mikami, Yohei, Philips, Rachael L., Sciumè, Giuseppe, Petermann, Franziska, Meylan, Françoise, Nagashima, Hiroyuki, Yao, Chen, Davis, Fred P., Brooks, Stephen R., Sun, Hong-Wei, Takahashi, Hayato, Poholek, Amanda C., Shih, Han-Yu, Afzali, Behdad, Muljo, Stefan A., Hafner, Markus, Kanno, Yuka, O’Shea, John J.

“…MicroRNAs are important regulators of immune responses. Here, we show miR-221 and miR-222 modulate the intestinal Th17 cell response. Expression of miR-221 and…”
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Histone deacetylase 3 represses cholesterol efflux during CD4 + T-cell activation by Wilfahrt, Drew, Philips, Rachael L, Lama, Jyoti, Kizerwetter, Monika, Shapiro, Michael Jeremy, McCue, Shaylene A, Kennedy, Madeleine M, Rajcula, Matthew J, Zeng, Hu, Shapiro, Virginia Smith

“…After antigenic activation, quiescent naive CD4 T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino…”
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Langerhans Cells Maintain Local Tissue Tolerance in a Model of Systemic Autoimmune Disease by King, Jennifer K, Philips, Rachael L, Eriksson, Anna U, Kim, Peter J, Halder, Ramesh C, Lee, Delphine J, Singh, Ram Raj

“…Systemic autoimmune diseases such as lupus affect multiple organs, usually in a diverse fashion where only certain organs are affected in individual patients…”
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Translating JAKs to Jakinibs by Gadina, Massimo, Chisolm, Danielle A, Philips, Rachael L, McInness, Iain B, Changelian, Paul S, O'Shea, John J

“…The discovery of JAKs and STATs and their roles in cytokine and IFN action represented a significant basic advance and a new paradigm in cell signaling. This…”
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Cutting Edge: HDAC3 Protects Double-Positive Thymocytes from P2X7 Receptor-Induced Cell Death by Philips, Rachael L, McCue, Shaylene A, Rajcula, Matthew J, Shapiro, Virginia S

“…Intricate life-versus-death decisions are programmed during T cell development, and the regulatory mechanisms that coordinate their activation and repression…”
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HDAC3 Is Required for the Downregulation of RORγt during Thymocyte Positive Selection by Philips, Rachael L, Chen, Meibo W, McWilliams, Douglas C, Belmonte, Paul J, Constans, Megan M, Shapiro, Virginia Smith

“…To generate functional peripheral T cells, proper gene regulation during T cell development is critical. In this study, we found that histone deacetylase…”
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Osteoblasts Protect AML Cells From SDF-1-Induced Apoptosis by Kremer, Kimberly N., Dudakovic, Amel, McGee-Lawrence, Meghan E., Philips, Rachael L., Hess, Allan D., Smith, B. Douglas, van Wijnen, Andre J., Karp, Judith E., Kaufmann, Scott H., Westendorf, Jennifer J., Hedin, Karen E.

“…ABSTRACT The bone marrow provides a protective environment for acute myeloid leukemia (AML) cells that often allows leukemic stem cells to survive standard…”
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Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease by Sharma, Mehul, Leung, Daniel, Momenilandi, Mana, Jones, Lauren C W, Pacillo, Lucia, James, Alyssa E, Murrell, Jill R, Delafontaine, Selket, Maimaris, Jesmeen, Vaseghi-Shanjani, Maryam, Del Bel, Kate L, Lu, Henry Y, Chua, Gilbert T, Di Cesare, Silvia, Fornes, Oriol, Liu, Zhongyi, Di Matteo, Gigliola, Fu, Maggie P, Amodio, Donato, Tam, Issan Yee San, Chan, Gavin Shueng Wai, Sharma, Ashish A, Dalmann, Joshua, van der Lee, Robin, Blanchard-Rohner, Géraldine, Lin, Susan, Philippot, Quentin, Richmond, Phillip A, Lee, Jessica J, Matthews, Allison, Seear, Michael, Turvey, Alexandra K, Philips, Rachael L, Brown-Whitehorn, Terri F, Gray, Christopher J, Izumi, Kosuke, Treat, James R, Wood, Kathleen H, Lack, Justin, Khleborodova, Asya, Niemela, Julie E, Yang, Xingtian, Liang, Rui, Kui, Lin, Wong, Christina Sze Man, Poon, Grace Wing Kit, Hoischen, Alexander, van der Made, Caspar I, Yang, Jing, Chan, Koon Wing, Rosa Duque, Jaime Sou Da, Lee, Pamela Pui Wah, Ho, Marco Hok Kung, Chung, Brian Hon Yin, Le, Huong Thi Minh, Yang, Wanling, Rohani, Pejman, Fouladvand, Ali, Rokni-Zadeh, Hassan, Changi-Ashtiani, Majid, Miryounesi, Mohammad, Puel, Anne, Shahrooei, Mohammad, Finocchi, Andrea, Rossi, Paolo, Rivalta, Beatrice, Cifaldi, Cristina, Novelli, Antonio, Passarelli, Chiara, Arasi, Stefania, Bullens, Dominique, Sauer, Kate, Claeys, Tania, Biggs, Catherine M, Morris, Emma C, Rosenzweig, Sergio D, O'Shea, John J, Wasserman, Wyeth W, Bedford, H Melanie, van Karnebeek, Clara D M, Palma, Paolo, Burns, Siobhan O, Meyts, Isabelle, Casanova, Jean-Laurent, Lyons, Jonathan J, Parvaneh, Nima, Nguyen, Anh Thi Van, Cancrini, Caterina, Heimall, Jennifer, Ahmed, Hanan, McKinnon, Margaret L, Lau, Yu Lung, Béziat, Vivien, Turvey, Stuart E

“…STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a central role in the pathophysiology of allergic inflammation…”
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HDAC3 protects DP thymocytes from P2X7 receptor-induced cell death by Philips, Rachael L., McCue, Shaylene A., Rajcula, Matthew J., Shapiro, Virginia S.

“…Intricate life-versus-death decisions are programmed during T cell development, and the regulatory mechanisms that coordinate their activation and repression…”
Get full text

Histone deacetylase 3 represses cholesterol efflux during CD4.sup.+ T-cell activation by Wilfahrt, Drew, Philips, Rachael L, Lama, Jyoti, Kizerwetter, Monika, Shapiro, Michael Jeremy, McCue, Shaylene A, Kennedy, Madeleine M, Rajcula, Matthew J, Zeng, Hu, Shapiro, Virginia Smith

“…After antigenic activation, quiescent naive CD4.sup.+ T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides,…”
Get full text

HDAC3 is required for the down-regulation of RORγt during thymocyte positive selection by Philips, Rachael L., Chen, Meibo W., McWilliams, Douglas C., Belmonte, Paul J., Constans, Megan M., Shapiro, Virginia Smith

“…To generate functional peripheral T cells, proper gene regulation during T cell development is critical. Here, we found that histone deacetylase 3 (HDAC3) is…”
Get full text

Langerhans Cells Maintain Local Tissue Tolerance in a Model of Systemic Autoimmune Disease1 by King, Jennifer K., Philips, Rachael L., Eriksson, Anna U., Kim, Peter J., Halder, Ramesh C., Lee, Delphine J., Singh, Ram Raj

“…Systemic autoimmune diseases such as lupus affect multiple organs, usually in a diverse fashion where only certain organs are affected in individual patients…”
Get full text