Search Results - "Philippov, Pavel P."

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy by Yang, Yuhui, Karakhanova, Svetlana, Hartwig, Werner, D'Haese, Jan G., Philippov, Pavel P., Werner, Jens, Bazhin, Alexandr V.

“…Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell signaling. Mitochondria in malignant cells differ structurally and…”
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Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches by Zernii, Evgeni Y, Baksheeva, Viktoriia E, Iomdina, Elena N, Averina, Olga A, Permyakov, Sergei E, Philippov, Pavel P, Zamyatnin, Andrey A, Senin, Ivan I

“…Over 100 million individuals are affected by irreversible visual impairments and blindness worldwide, while ocular diseases remain a challenging problem…”
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Mechanisms and Treatment of Light-Induced Retinal Degeneration-Associated Inflammation: Insights from Biochemical Profiling of the Aqueous Humor by Chistyakov, Dmitry V, Baksheeva, Viktoriia E, Tiulina, Veronika V, Goriainov, Sergei V, Azbukina, Nadezhda V, Gancharova, Olga S, Arifulin, Eugene A, Komarov, Sergey V, Chistyakov, Viktor V, Tikhomirova, Natalia K, Zamyatnin, Andrey A, Philippov, Pavel P, Senin, Ivan I, Sergeeva, Marina G, Zernii, Evgeni Yu

“…Ocular inflammation contributes to the pathogenesis of blind-causing retinal degenerative diseases, such as age-related macular degeneration (AMD) or photic…”
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Disulfide Dimerization of Neuronal Calcium Sensor-1: Implications for Zinc and Redox Signaling by Baksheeva, Viktoriia E, Baldin, Alexey V, Zalevsky, Arthur O, Nazipova, Aliya A, Kazakov, Alexey S, Vladimirov, Vasiliy I, Gorokhovets, Neonila V, Devred, François, Philippov, Pavel P, Bazhin, Alexandr V, Golovin, Andrey V, Zamyatnin, Jr, Andrey A, Zinchenko, Dmitry V, Tsvetkov, Philipp O, Permyakov, Sergei E, Zernii, Evgeni Yu

“…Neuronal calcium sensor-1 (NCS-1) is a four-EF-hand ubiquitous signaling protein modulating neuronal function and survival, which participates in…”
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In Vivo Immunological Effects of CD73 Deficiency by Adam, Thomas, Mathes, Andreas, Isayev, Orkhan, Philippov, Pavel P, Werner, Jens, Karakhanova, Svetlana, Bazhin, Alexandr V

“…The extracellular ecto-5'-nucleotidase (CD73) is involved in the production of immunosuppressive adenosin (Ado), which can influence different immune cells…”
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Mitochondria-targeted antioxidant SKQ1 protects cornea from oxidative damage induced by ultraviolet irradiation and mechanical injury by Zernii, Evgeni Yu, Gancharova, Olga S, Tiulina, Veronika V, Zamyatnin, Jr, Andrey A, Philippov, Pavel P, Baksheeva, Viktoriia E, Senin, Ivan I

“…Cornea protects the eye against natural and anthropogenic ultraviolet (UV) damage and mechanical injury. Corneal incisions produced by UV lasers in ophthalmic…”
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Suppression of Light-Induced Oxidative Stress in the Retina by Mitochondria-Targeted Antioxidant by Baksheeva, Viktoriia E, Tiulina, Veronika V, Tikhomirova, Natalia K, Gancharova, Olga S, Komarov, Sergey V, Philippov, Pavel P, Zamyatnin, Jr, Andrey A, Senin, Ivan I, Zernii, Evgeni Yu

“…Light-induced oxidation of lipids and proteins provokes retinal injuries and results in progression of degenerative retinal diseases, such as, for instance,…”
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Redox Regulation of Signaling Complex between Caveolin-1 and Neuronal Calcium Sensor Recoverin by Vladimirov, Vasiliy I, Shchannikova, Margarita P, Baldin, Alexey V, Kazakov, Alexey S, Shevelyova, Marina P, Nazipova, Aliya A, Baksheeva, Viktoriia E, Nemashkalova, Ekaterina L, Frolova, Anastasia S, Tikhomirova, Natalia K, Philippov, Pavel P, Zamyatnin, Andrey A, Permyakov, Sergei E, Zinchenko, Dmitry V, Zernii, Evgeni Yu

“…Caveolin-1 is a cholesterol-binding scaffold protein, which is localized in detergent-resistant membrane (DRM) rafts and interacts with components of signal…”
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Light-Induced Thiol Oxidation of Recoverin Affects Rhodopsin Desensitization by Zernii, Evgeni Yu, Nazipova, Aliya A, Nemashkalova, Ekaterina L, Kazakov, Alexey S, Gancharova, Olga S, Serebryakova, Marina V, Tikhomirova, Natalya K, Baksheeva, Viktoriia E, Vladimirov, Vasiliy I, Zinchenko, Dmitry V, Philippov, Pavel P, Senin, Ivan I, Permyakov, Sergei E

“…The excessive light illumination of mammalian retina is known to induce oxidative stress and photoreceptor cell death linked to progression of age-related…”
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Involvement of the recoverin C-terminal segment in recognition of the target enzyme rhodopsin kinase by Zernii, Evgeni Yu, Komolov, Konstantin E, Permyakov, Sergei E, Kolpakova, Tatiana, Dell'orco, Daniele, Poetzsch, Annika, Knyazeva, Ekaterina L, Grigoriev, Ilya I, Permyakov, Eugene A, Senin, Ivan I, Philippov, Pavel P, Koch, Karl-Wilhelm

“…NCS (neuronal Ca2+ sensor) proteins belong to a family of calmodulin-related EF-hand Ca2+-binding proteins which, in spite of a high degree of structural…”
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Inflammation in Dry Eye Syndrome: Identification and Targeting of Oxylipin-Mediated Mechanisms by Chistyakov, Dmitry V., Gancharova, Olga S., Baksheeva, Viktoriia E., Tiulina, Veronika V., Goriainov, Sergei V., Azbukina, Nadezhda V., Tsarkova, Marina S., Zamyatnin, Andrey A., Philippov, Pavel P., Sergeeva, Marina G., Senin, Ivan I., Zernii, Evgeni Yu

“…Dry eye syndrome (DES) is characterized by decreased tear production and stability, leading to desiccating stress, inflammation and corneal damage. DES…”
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Membrane Binding of Neuronal Calcium Sensor-1: Highly Specific Interaction with Phosphatidylinositol-3-Phosphate by Baksheeva, Viktoriia E, Nemashkalova, Ekaterina L, Firsov, Alexander M, Zalevsky, Arthur O, Vladimirov, Vasily I, Tikhomirova, Natalia K, Philippov, Pavel P, Zamyatnin, Jr, Andrey A, Zinchenko, Dmitry V, Antonenko, Yuri N, Permyakov, Sergey E, Zernii, Evgeni Yu

“…Neuronal calcium sensors are a family of N-terminally myristoylated membrane-binding proteins possessing a different intracellular localization and thereby…”
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Cancer‐retina antigens as potential paraneoplastic antigens in melanoma‐associated retinopathy by Bazhin, Alexandr V., Dalke, Claudia, Willner, Nadine, Abschütz, Oliver, Wildberger, Hannes G. H., Philippov, Pavel P., Dummer, Reinhard, Graw, Jochen, de Angelis, Martin Hrabé, Schadendorf, Dirk, Umansky, Viktor, Eichmüller, Stefan B.

“…Melanoma‐associated retinopathy is a rare paraneoplastic neurological syndrome characterized by retinopathy in melanoma patients. The main photoreceptor…”
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Photoreceptor proteins as cancer‐retina antigens by Bazhin, Alexandr V., Schadendorf, Dirk, Willner, Nadine, De Smet, Charles, Heinzelmann, Anita, Tikhomirova, Natalya K., Umansky, Viktor, Philippov, Pavel P., Eichmüller, Stefan B.

“…Melanocytes, melanoma and photoreceptor cells are of neuroectodermal origin and have a certain sensitivity to light. In this study, we present evidence for…”
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Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells by Bazhin, Alexandr V., De Smet, Charles, Golovastova, Marina O., Schmidt, Jan, Philippov, Pavel P.

“…Please cite this paper as: Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells. Experimental…”
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Tuning of a Neuronal Calcium Sensor by Weiergräber, Oliver H., Senin, Ivan I., Zernii, Eugene Yu, Churumova, Valeriya A., Kovaleva, Nadezhda A., Nazipova, Aliya A., Permyakov, Sergei E., Permyakov, Eugene A., Philippov, Pavel P., Granzin, Joachim, Koch, Karl-Wilhelm

“…Recoverin is a Ca2+-regulated signal transduction modulator expressed in the vertebrate retina that has been implicated in visual adaptation. An intriguing…”
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Reactive Oxygen Species in Cancer Biology and Anticancer Therapy by Bazhin, Alexandr V., Philippov, Pavel P., Karakhanova, Svetlana

“…[...]the authors hypothesize that novel therapeutic approaches against lung cancer may be based on the use of H2O2. Hung et al. in their review "Roles of…”
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Ca2+-Myristoyl Switch in the Neuronal Calcium Sensor Recoverin Requires Different Functions of Ca2+-binding Sites by Senin, Ivan I., Fischer, Torsten, Komolov, Konstantin E., Zinchenko, Dimitry V., Philippov, Pavel P., Koch, Karl-Wilhelm

“…Recoverin is an EF-hand Ca2+-binding protein that is suggested to control the activity of the G-protein-coupled receptor kinase GRK-1 or rhodopsin kinase in a…”
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Critical Role of Electrostatic Interactions of Amino Acids at the Cytoplasmic Region of Helices 3 and 6 in Rhodopsin Conformational Properties and Activation by Ramon, Eva, Cordomí, Arnau, Bosch, Laia, Zernii, Eugeni Yu, Senin, Ivan I., Manyosa, Joan, Philippov, Pavel P., Pé;rez, Juan J., Garriga, Pere

“…The cytoplasmic sides of transmembrane helices 3 and 6 of G-protein-coupled receptors are connected by a network of ionic interactions that play an important…”
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Recoverin and Rhodopsin Kinase Activity in Detergent-resistant Membrane Rafts from Rod Outer Segments by Senin, Ivan I, Höppner-Heitmann, Doris, Polkovnikova, Olga O, Churumova, Valeriya A, Tikhomirova, Natalya K, Philippov, Pavel P, Koch, Karl-Wilhelm

“…Cholesterol-rich membranes or detergent-resistant membranes (DRMs) have recently been isolated from bovine rod outer segments and were shown to contain several…”
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