Search Results - "Philippens, I."

Citrullinated human and murine MOG35–55 display distinct biophysical and biochemical behavior by Doelman, W., Reijnen, R.C., Dijksman, N., Janssen, A.P.A., van Driel, N., ’t Hart, B.A., Philippens, I., Araman, C., Baron, W., van Kasteren, S.I.

“…The peptide spanning residues 35 to 55 of the protein myelin oligodendrocyte glycoprotein (MOG) has been studied extensively in its role as a key autoantigen…”
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Progression and recovery of Parkinsonism in a chronic progressive MPTP-induction model in the marmoset without persistent molecular and cellular damage by Franke, S.K, van Kesteren, R.E, Wubben, J.A.M, Hofman, S, Paliukhovich, I, van der Schors, R.C, van Nierop, P, Smit, A.B, Philippens, I.H.C.H.M

“…Highlights • A chronic slow progressive marmoset MPTP model for early PD progression and recovery is presented. • Parkinsonian symptoms can occur without…”
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Exploring the neuroprotective effects of modafinil in a marmoset Parkinson model with immunohistochemistry, magnetic resonance imaging and spectroscopy by van Vlieta, S.A.M, Blezer, E.L.A, Jongsma, M.J, Vanwersch, R.A.P, Olivier, B, Philippens, I.H.C.H.M

“…Abstract Neuroprotective therapeutics stop or slow down the degeneration process in animal models of Parkinson's disease (PD). Neuronal survival in PD animal…”
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Beneficial effects of TCP on soman intoxication in guinea pigs: seizures, brain damage and learning behaviour by de Groot, D. M. G., Bierman, E. P. B., Bruijnzeel, P. L. B., Carpentier, P., Kulig, B. M., Lallement, G., Melchers, B. P. C., Philippens, I. H. C. H. M., van Huygevoort, A. H. B. M.

“…Poisoning with the potent nerve agent soman produces a cascade of central nervous system (CNS) effects characterized by severe convulsions and eventually…”
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Subchronic Physostigmine Pretreatment in Marmosets: Absence of Side Effects and Effectiveness against Soman Poisoning with Negligible Postintoxication Incapacitation by Philippens, I. H. C. H. M., Vanwersch, R. A. P., Groen, B., Olivier, B., Bruijnzeel, P. L. B., Melchers, B. P. C.

“…Subchronic pretreatment with physostigmine (PHY) (0.0125 mg/kg/h) leading to a blood acetylcholinesterase inhibition of about 30% caused no side effects when…”
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Scopolamine Augments the Efficacy of Physostigmine Against Soman Poisoning in Guinea Pigs by Philippens, Ingrid H.C.H.M, Melchers, Bert P.C, Olivier, Berend, Bruijnzeel, Piet L.B

“…The efficacy of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or without the muscarinergic receptor…”
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Effects of Physostigmine on the Startle in Guinea Pigs: Two Mechanisms Involved by Philippens, I.H.C.H.M, Olivier, B, Melchers, B.P.C

“…The effects of the acetylcholinesterase inhibitor physostigmine (PHY) on the auditory startle reflex in guinea pigs were studied. The dose–response curve of…”
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Comparison of the efficacy of single or repeated HI-6 treatment following soman poisoning in guinea pigs and marmoset monkeys by BUSKER, R. W, ZIJLSTRA, J. J, PHILIPPENS, I. H. C. H. M, GROEN, B, MELCHERS, B. P. C

“…The therapeutic efficacy of single or repeated doses of HI-6, together with atropine, against soman poisoning were compared both in guinea pigs and in marmoset…”
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Citrullinated human and murine MOG 35-55 display distinct biophysical and biochemical behavior by Doelman, W, Reijnen, R C, Dijksman, N, Janssen, A P A, van Driel, N, 't Hart, B A, Philippens, I, Araman, C, Baron, W, van Kasteren, S I

“…The peptide spanning residues 35 to 55 of the protein myelin oligodendrocyte glycoprotein (MOG) has been studied extensively in its role as a key autoantigen…”
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Side effects of physostigmine as a pretreatment in guinea pigs by Philippens, Ingrid H.C.H.M., Wolthuis, Otto L., Busker, Ruud W., Langenberg, Jan P., Melchers, Bert P.C.

“…To prevent incapacitation following nerve agent intoxications, it is proposed to replace pyridostigmine by the centrally active carbamate physostigmine (PHY)…”
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Efficacy of HI-6 and HLö-7 in preventing incapacitation following nerve agent poisoning by Melchers, B P, Philippens, I H, Wolthuis, O L

“…The therapeutic efficacy of the oximes HI-6 and HLö-7 (132.5 mumol/kg), in combination with atropine, in soman- or tabun-intoxicated guinea pigs was compared,…”
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Behavioral performance, brain histology, and EEG sequela after immediate combined atropine/diazepam treatment of soman-intoxicated rats by Philippens, I H, Melchers, B P, de Groot, D M, Wolthuis, O L

“…It is known that rats poisoned with near-lethal doses of pinacolyl methylphosphonofluoridate (soman) develop brain lesions, particularly when convulsions are…”
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A simple automated test to measure exploratory and motor activity of marmosets by Wolthuis, O L, Groen, B, Philippens, I H

“…An automated device is described to test the exploratory and motor activity of common marmosets (Callithrix jacchus). The device consists of four boxes…”
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On the development of behavioral tolerance to organophosphates. III: Behavioral aspects by Wolthuis, O L, Philippens, I H, Vanwersch, R

“…As part of a study on the mechanisms underlying behavioral tolerance to cholinesterase-inhibiting organophosphates (OP's) the present investigation was…”
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Side effects of therapeutic drugs against organophosphate poisoning by Wolthuis, O L, Philippens, I H, Vanwersch, R A

“…The possible side effects of therapeutic drugs against organophosphate poisoning were investigated. First, dose-effect curves were obtained with atropine…”
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Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer's Disease by Philippens, Ingrid H, Ormel, Paul R, Baarends, Guus, Johansson, Maja, Remarque, Ed J, Doverskog, Magnus

“…The immune system is increasingly mentioned as a potential target for Alzheimer's disease (AD) treatment. In the present pilot study, the effect of…”
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Behavioral test systems in marmoset monkeys by Philippens, I H, Melchers, B P, Roeling, T A, Bruijnzeel, P L

“…A number of neurobehavioral methods have been developed to test behavior in marmoset monkeys. These test systems are (1) the bungalow test, which quantifies…”
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Erratum to “Exploring the neuroprotective effects of modafinil in a marmoset Parkinson model with immunohistochemistry, magnetic resonance imaging and spectroscopy” [Brain Res. 1189 (2008) 219–228] by van Vliet, S.A.M, Blezer, E.L.A, Jongsma, M.J, Vanwersch, R.A.P, Olivier, B, Philippens, I.H.C.H.M

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Subchronic Physostigmine Pretreatment in Guinea Pigs: Effective Against Soman and Without Side Effects by Philippens, Ingrid H.C.H.M, Busker, Ruud W, Wolthuis, Otto L, Olivier, Berend, Bruijnzeel, Piet L.B, Melchers, Bert P.C

“…The behavioral and neurophysiological effects of the subchronically administered cholinesterase-inhibitor physostigmine (PHY) (0.025 mg/kg/h) either with or…”
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Beneficial effects of TCP on soman intoxication in guinea pigs: Seizures, brain damage and learning behaviour: Medical Countermeasures for Nerve Agents by DE GROOT, D. M. G, BIERMAN, E. P. B, BRUIJNZEEL, P. L. B, CARPENTIER, P, KULIG, B. M, LALLEMENT, G, MELCHERS, B. P. C, PHILIPPENS, I. H. C. H. M, VAN HUYGEVOORT, A. H. B. M

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