Search Results - "Philippen, Leonne E"

SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity by Quick, Ann P, Wang, Qiongling, Philippen, Leonne E, Barreto-Torres, Giselle, Chiang, David Y, Beavers, David, Wang, Guoliang, Khalid, Maha, Reynolds, Julia O, Campbell, Hannah M, Showell, Jordan, McCauley, Mark D, Scholten, Arjen, Wehrens, Xander H.T

“…RATIONALE:Junctional membrane complexes (JMCs) in myocytes are critical microdomains, in which excitation–contraction coupling occurs. Structural and…”
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Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure by Raso, Andrea, Dirkx, Ellen, Philippen, Leonne E., Fernandez-Celis, Amaya, De Majo, Federica, Sampaio-Pinto, Vasco, Sansonetti, Marida, Juni, Rio, el Azzouzi, Hamid, Calore, Martina, Bitsch, Nicole, Olieslagers, Servé, Oerlemans, Martinus I.F.J., Huibers, Manon M., de Weger, Roel A., Reckman, Yolan J., Pinto, Yigal M., Zentilin, Lorena, Zacchigna, Serena, Giacca, Mauro, da Costa Martins, Paula A., López-Andrés, Natalia, De Windt, Leon J.

“…Heart failure is preceded by ventricular remodeling, changes in left ventricular mass, and myocardial volume after alterations in loading conditions…”
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Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure by Dirkx, Ellen, Gladka, Monika M., Philippen, Leonne E., Armand, Anne-Sophie, Kinet, Virginie, Leptidis, Stefanos, el Azzouzi, Hamid, Salic, Kanita, Bourajjaj, Meriem, da Silva, Gustavo J. J., Olieslagers, Servé, van der Nagel, Roel, de Weger, Roel, Bitsch, Nicole, Kisters, Natasja, Seyen, Sandrine, Morikawa, Yuka, Chanoine, Christophe, Heymans, Stephane, Volders, Paul G. A., Thum, Thomas, Dimmeler, Stefanie, Cserjesi, Peter, Eschenhagen, Thomas, da Costa Martins, Paula A., De Windt, Leon J.

“…Although aberrant reactivation of embryonic gene programs is intricately linked to pathological heart disease, the transcription factors driving these gene…”
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Novel Junctophilin-2 Mutation A405S Is Associated With Basal Septal Hypertrophy and Diastolic Dysfunction by Quick, Ann P., BA, Landstrom, Andrew P., MD, PhD, Wang, Qiongling, PhD, Beavers, David L., MD, PhD, Reynolds, Julia O., BS, Barreto-Torres, Giselle, PhD, Tran, Viet, MD, Showell, Jordan, BS, Philippen, Leonne E., MSc, Morris, Shaine A., MD, MPH, Skapura, Darlene, BS, Bos, J. Martijn, MD, Pedersen, Steen E., PhD, Pautler, Robia G., PhD, Ackerman, Michael J., MD, PhD, Wehrens, Xander H.T., MD, PhD

“…Visual Abstract…”
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Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector by Ni, Li, Scott, Larry, Campbell, Hannah M, Pan, Xiaolu, Alsina, Katherina M, Reynolds, Julia, Philippen, Leonne E, Hulsurkar, Mohit, Lagor, William R, Li, Na, Wehrens, Xander H.T

“…RATIONALE:Somatic overexpression in mice using an adeno-associated virus (AAV) as gene transfer vectors has become a valuable tool to analyze the roles of…”
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Non-coding RNA in control of gene regulatory programs in cardiac development and disease by Philippen, Leonne E, Dirkx, Ellen, da Costa-Martins, Paula A, De Windt, Leon J

“…Abstract Organogenesis of the vertebrate heart is a highly specialized process involving progressive specification and differentiation of distinct embryonic…”
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Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release by Reynolds, Julia O., Quick, Ann P., Wang, Qiongling, Beavers, David L., Philippen, Leonne E., Showell, Jordan, Barreto-Torres, Giselle, Thuerauf, Donna J., Doroudgar, Shirin, Glembotski, Christopher C., Wehrens, Xander H.T.

“…Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine…”
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Antisense MicroRNA Therapeutics in Cardiovascular Disease: Quo Vadis? by Philippen, Leonne E, Dirkx, Ellen, Wit, Jan B M, Burggraaf, Koos, de Windt, Leon J, da Costa Martins, Paula A

“…Heart failure (HF) is the end result of a diverse set of causes such as genetic cardiomyopathies, coronary artery disease, and hypertension and represents the…”
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Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71 by van Domselaar, Robert, Philippen, Leonne E, Quadir, Razi, Wiertz, Emmanuel J H J, Kummer, J Alain, Bovenschen, Niels

“…Granzyme M (GrM) is highly expressed in cytotoxic granules of NK cells, which provide the first line of defense against viral pathogens. GrM knockout mice show…”
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‘Striated Muscle Preferentially Expressed Protein Kinase’ (SPEG) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity by Quick, Ann P., Wang, Qiongling, Philippen, Leonne E., Barreto-Torres, Giselle, Chiang, David Y., Beavers, David, Wang, Guoliang, Khalid, Maha, Reynolds, Julia O., Campbell, Hannah M., Showell, Jordan, McCauley, Mark D., Scholten, Arjen, Wehrens, Xander H. T.

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Abstract 35: Pseudo-knockin Mice Expressing JPH2-A399S Develop Cardiac Hypertrophy by Magnetic Resonance Imaging by Quick, Ann P, Beavers, David L, Showell, Jordan, Philippen, Leonne E, Landstrom, Andrew P, Morris, Shaine A, Pautler, Robia G, Wehrens, Xander H

“…Abstract only Background: Dysfunctional intracellular Ca2+ handling has been implicated in adverse cardiac remodeling leading to hypertrophy and failure…”
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Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca 2 + release by Reynolds, Julia O, Quick, Ann P, Wang, Qiongling, Beavers, David L, Philippen, Leonne E, Showell, Jordan, Barreto-Torres, Giselle, Theurauf, Donna J, Doroudgar, Shirin, Glembotski, Christopher C, Wehrens, Xander H.T

“…Abstract Background Junctophilin-2 (JPH2) is the primary structural protein for coupling of transverse (T)-tubule associated cardiac L-type Ca channels and…”
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