Search Results - "Philip J. Rosner"

Strategic Use of Affinity-Based Mass Spectrometry Techniques in the Drug Discovery Process by Kelly, Michele A, McLellan, Thomas J, Rosner, Philip J

“…Advances in biomolecular mass spectrometry (Bio-MS) have made this technique an invaluable tool for analytical chemists and biochemists alike. The…”
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A Low-Affinity Ca2+-Dependent Association of Calmodulin With the Rab3A Effector Domain Inversely Correlates With Insulin Exocytosis by KAJIO, Hiroshi, OLSZEWSKI, Scott, ROSNER, Philip J, DONELAN, Matthew J, GEOGHEGAN, Kieran F, RHODES, Christopher J

“…A Low-Affinity Ca 2+ -Dependent Association of Calmodulin With the Rab3A Effector Domain Inversely Correlates With Insulin Exocytosis Hiroshi Kajio 1 , Scott…”
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Frontal affinity chromatography–mass spectrometry assay technology for multiple stages of drug discovery: applications of a chromatographic biosensor by Chan, Nora W.C, Lewis, Darren F, Rosner, Philip J, Kelly, Michele A, Schriemer, David C

“…This article presents new concepts in affinity chromatography/mass spectrometry for the study of molecular interactions. Chromatographic assays involving…”
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Dye-Pair Reporter Systems for Protein−Peptide Molecular Interactions by Geoghegan, Kieran F, Rosner, Philip J, Hoth, Lise R

“…Modifying a linear peptide near each terminus with a fluorescent dye can make it able to signal its own binding to a protein. As originally described, the dye…”
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Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1 beta Posttranslational Processing by Laliberte, R E, Perregaux, D G, Hoth, L R, Rosner, P J, Jordan, C K, Peese, K M, Eggler, J, Dombroski, MA, Geoghegan, K F, Gabel, CA

“…Stimulus-induced posttranslational processing of human monocyte interleukin-1 beta (IL-1 beta ) is accompanied by major changes to the intracellular ionic…”
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Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage by Mitchell, P G, Magna, H A, Reeves, L M, Lopresti-Morrow, L L, Yocum, S A, Rosner, P J, Geoghegan, K F, Hambor, J E

“…Proteolysis of triple-helical collagen is an important step in the progression toward irreversible tissue damage in osteoarthritis. Earlier work on the…”
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Spontaneous alpha-N-6-phosphogluconoylation of a "His tag" in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins by Geoghegan, K F, Dixon, H B, Rosner, P J, Hoth, L R, Lanzetti, A J, Borzilleri, K A, Marr, E S, Pezzullo, L H, Martin, L B, LeMotte, P K, McColl, A S, Kamath, A V, Stroh, J G

“…Several proteins expressed in Escherichia coli with the N-terminus Gly-Ser-Ser-[His]6- consisted partly (up to 20%) of material with 178 Da of excess mass,…”
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A low-affinity [Ca.sup.2+]-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis by Kajio, Hiroshi, Olszewski, Scott, Rosner, Philip J, Donelan, Matthew J, Geoghegan, Kieran F, Rhodes, Christopher J

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Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing by Laliberte, Ronald E, Perregaux, David G, Hoth, Lise R, Rosner, Philip J, Jordan, Crystal K, Peese, Kevin M, Eggler, James F, Dombroski, Mark A, Geoghegan, Kieran F, Gabel, Christopher A

“…Stimulus-induced posttranslational processing of human monocyte interleukin-1beta (IL-1beta) is accompanied by major changes to the intracellular ionic…”
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Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1β Posttranslational Processing by Ronald E. Laliberte, David G. Perregaux, Lise R. Hoth, Philip J. Rosner, Crystal K. Jordan, Kevin M. Peese, James. F. Eggler, Mark A. Dombroski, Kieran F. Geoghegan, Christopher A. Gabel

“…Stimulus-induced posttranslational processing of human monocyte interleukin-1β (IL-1β) is accompanied by major changes to the intracellular ionic…”
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Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1औ Posttranslational Processing by Laliberte, Ronald E., Perregaux, David G., Hoth, Lise R., Rosner, Philip J., Jordan, Crystal K., Peese, Kevin M., Eggler, James.F., Dombroski, Mark A., Geoghegan, Kieran F., Gabel, Christopher A.

“…Stimulus-induced posttranslational processing of human monocyte interleukin-1औ (IL-1औ) is accompanied by major changes to the intracellular ionic environment,…”
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Spontaneous α-N-6-Phosphogluconoylation of a “His Tag” inEscherichia coli:The Cause of Extra Mass of 258 or 178 Da in Fusion Proteins by Geoghegan, Kieran F., Dixon, Henry B.F., Rosner, Philip J., Hoth, Lise R., Lanzetti, Anthony J., Borzilleri, Kris A., Marr, Eric S., Pezzullo, Linda H., Martin, LeRoy B., LeMotte, Peter K., McColl, Alexander S., Kamath, Ajith V., Stroh, Justin G.

“…Several proteins expressed inEscherichia coliwith the N-terminus Gly-Ser-Ser-[His]6- consisted partly (up to 20%) of material with 178 Da of excess mass,…”
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