Search Results - "Philibert, Keith"

Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease by Patterson, Kristina R., Remmers, Christine, Fu, Yifan, Brooker, Sarah, Kanaan, Nicholas M., Vana, Laurel, Ward, Sarah, Reyes, Juan F., Philibert, Keith, Glucksman, Marc J., Binder, Lester I.

“…Neurofibrillary tangles, composed of insoluble aggregates of the microtubule-associated protein Tau, are a pathological hallmark of Alzheimer disease (AD) and…”
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Primate Genome Gain and Loss: A Bone Dysplasia, Muscular Dystrophy, and Bone Cancer Syndrome Resulting from Mutated Retroviral-Derived MTAP Transcripts by Camacho-Vanegas, Olga, Camacho, Sandra Catalina, Till, Jacob, Miranda-Lorenzo, Irene, Terzo, Esteban, Ramirez, Maria Celeste, Schramm, Vern, Cordovano, Grace, Watts, Giles, Mehta, Sarju, Kimonis, Virginia, Hoch, Benjamin, Philibert, Keith D., Raabe, Carsten A., Bishop, David F., Glucksman, Marc J., Martignetti, John A.

“…Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMS-MFH) is an autosomal-dominant syndrome characterized by bone dysplasia, myopathy, and…”
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EP24.15 as a Potential Regulator of Kisspeptin Within the Neuroendocrine Hypothalamus by Woitowich, Nicole C, Philibert, Keith D, Leitermann, Randy J, Wungjiranirun, Manida, Urban, Janice H, Glucksman, Marc J

“…The neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are…”
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Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches by Philibert, Keith D, Marr, Robert A, Norstrom, Eric M, Glucksman, Marc J

“…Currently, there are very limited pharmaceutical interventions for Alzheimer's disease (AD) to alleviate the amyloid burden implicated in the pathophysiology…”
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The role of neuropeptide processing enzymes in endocrine (prostate) cancer: EC 3.4.24.15 (EP24.15) by Swanson, Todd A, Kim, Sandra I, Myers, Michael, Pabon, Amanda, Philibert, Keith D, Wang, Mina, Glucksman, Marc J

“…The zinc metalloendopeptidase EC3.4.24.15 [EP24.15, thimet oligopeptidase], a neuropeptide processing enzyme, is central to the formation and degradation of…”
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Elucidating the Reproductome: System‐wide Regulation of Reproductive Neuropeptides by Glucksman, Marc, Philibert, Keith, Woitowich, Nicole, Urban, Janice, DeJoseph, Gina

“…Abstract only Kisspeptin (Kiss), neurokinin B (NKB) and dynorphin A (DynA), collectively known as the KNDy neurons in the hypothalamus, drive the activity of…”
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Thimet Oligopeptidase (EP24.15), a Neuropeptide Processing Enzyme Regulating Xenin Signaling by Glucksman, Marc, Philibert, Keith, Mizuno, Tooru, Lew, Piesan

“…Abstract only Xenin is a 25 amino acid neuropeptide with sequence homology and actions similar to hypothalamic and ileal neurotensin (a satiety factor) as well…”
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EC 3.4.24.15 is a Putative Regulator of Kisspeptin Signaling by Woitowich, Nicole, Philibert, Keith, DeJoseph, Mary, Urban, Janice, Glucksman, Marc

“…Abstract only Inadequate kisspeptin (Kiss) secretion or signaling results in delayed puberty and infertility, indicating the importance of this peptide in…”
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The APP Interactome: Identifying Targets in Alzheimer's Disease by Glucksman, Marc, Philibert, Keith, Marr, Robert, Norstrom, Eric

“…Abstract only Alzheimer's disease (AD) is a horrific neurodegenerative disorder affecting the elderly with progressive mental decline and profound effects on…”
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Ome is where the Wound is: Biomarkers of Healing in Chronic Diabetic Foot Ulcers by Glucksman, Marc, Philibert, Keith, Shao, Xiaomeng, Yang, Charlie, Ortiz, Jacque, Wu, Stephanie

“…Abstract only Of the approximate 30 million Americans that suffer from Type 2 diabetes, 25% will develop a foot ulcer during their lifetime that often exhibit…”
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SUN-478 The Role of Thimet Oligopeptidase (EP24.15) in Regulating Reproduction by Glucksman, Joshua, DeJoseph, M. Regina, Philibert, Keith, Urban, Janice

“…For almost six decades, gonadotropin releasing hormone (GnRH) has been examined biochemically and physiologically in the hormonal control of reproduction. More…”
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Identification and characterization of Aβ peptide interactors in Alzheimer’s disease by structural approaches by Philibert, Keith D., Marr, Robert A., Norstrom, Eric M., Glucksman, Marc J.

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Abstract LB-89: Discovery and characterization of novel MTAP splice variants resulting in a hereditary form of osteosarcoma and demonstration of their dysregulation in sporadic forms of this cancer by Camacho-Vanegas, Olga, Camacho, Sandra C., Till, Jacob, Miranda-Lorenzo, Irene, Terzo, Esteban, Ramirez, Maria C., Schramm, Vern, Cordovano, Grace, Watts, Giles, Mehta, Sarju, Kimonis, Virginia, Hoch, Benjamin, Philibert, Keith D., Raabe, Carsten A., Bishop, David F., Glucksman, Marc J., Martignetti, John A.

“…Abstract Hereditary cancer syndromes represent a powerful and tractable biologic system for identifying cancer-causing genes. Though the syndromes themselves…”
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Human membrane metallo-endopeptidase-like protein (MMEL) degrades both Aβ42 and Aβ40 by Huang, Jeffrey Y., Bruno, Angela M., Patel, Chetak A., Huynh, Alexis M., Philibert, Keith D., Glucksman, Marc J., Marr, Robert A.

“…Beta-amyloid (Aβ) degrading endopeptidases are thought to protect against Alzheimer disease (AD) and are potentially therapeutic. Of particular interest are…”
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Evidence for multisite ADP-ribosylation of neuronal phosphoprotein B-50/GAP-43 by Philibert, K, Zwiers, H

“…The neuronal phosphoprotein B-50/GAP-43 is associated with neuronal growth and regeneration and is involved in the calcium/CaM and G(o) signal transduction…”
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