Search Results - "Phesse, Toby J"

Targeting Wnt Signaling for the Treatment of Gastric Cancer by Koushyar, Sarah, Powell, Arfon G, Vincan, Elizabeth, Phesse, Toby J

“…The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeostasis. Wnt signaling controls…”
Get full text

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis by Rickard, James A., O’Donnell, Joanne A., Evans, Joseph M., Lalaoui, Najoua, Poh, Ashleigh R., Rogers, TeWhiti, Vince, James E., Lawlor, Kate E., Ninnis, Robert L., Anderton, Holly, Hall, Cathrine, Spall, Sukhdeep K., Phesse, Toby J., Abud, Helen E., Cengia, Louise H., Corbin, Jason, Mifsud, Sandra, Di Rago, Ladina, Metcalf, Donald, Ernst, Matthias, Dewson, Grant, Roberts, Andrew W., Alexander, Warren S., Murphy, James M., Ekert, Paul G., Masters, Seth L., Vaux, David L., Croker, Ben A., Gerlic, Motti, Silke, John

“…Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and…”
Get full text

Lgr5 joins the club of gastric stem cell markers in the corpus by Phesse, Toby J., Sansom, Owen J.

“…Several markers of gastric stem cells have been identified in recent years. Now a study demonstrates that Lgr5 marks a population of reserve stem cells located…”
Get full text

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis by Bollrath, Julia, Phesse, Toby J., von Burstin, Vivian A., Putoczki, Tracy, Bennecke, Moritz, Bateman, Trudie, Nebelsiek, Tim, Lundgren-May, Therese, Canli, Özge, Schwitalla, Sarah, Matthews, Vance, Schmid, Roland M., Kirchner, Thomas, Arkan, Melek C., Ernst, Matthias, Greten, Florian R.

“…Although gastrointestinal cancers are frequently associated with chronic inflammation, the underlying molecular links have not been comprehensively deciphered…”
Get full text

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells by Flanagan, Dustin J., Phesse, Toby J., Barker, Nick, Schwab, Renate H.M., Amin, Nancy, Malaterre, Jordane, Stange, Daniel E., Nowell, Cameron J., Currie, Scott A., Saw, Jarel T.S., Beuchert, Eva, Ramsay, Robert G., Sansom, Owen J., Ernst, Matthias, Clevers, Hans, Vincan, Elizabeth

“…The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cells intermingled with Paneth…”
Get full text

Exploring the Wnt Pathway as a Therapeutic Target for Prostate Cancer by Koushyar, Sarah, Meniel, Valerie S, Phesse, Toby J, Pearson, Helen B

“…Aberrant activation of the Wnt pathway is emerging as a frequent event during prostate cancer that can facilitate tumor formation, progression, and therapeutic…”
Get full text

The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer by Routledge, Daniel, Rogers, Sally, Ono, Yosuke, Brunt, Lucy, Meniel, Valerie, Tornillo, Giusy, Ashktorab, Hassan, Phesse, Toby J, Scholpp, Steffen

“…The Wnt/β-catenin signalling pathway regulates multiple cellular processes during development and many diseases, including cell proliferation, migration, and…”
Get full text

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling by Ashton, Gabrielle H., Morton, Jennifer P., Myant, Kevin, Phesse, Toby J., Ridgway, Rachel A., Marsh, Victoria, Wilkins, Julie A., Athineos, Dimitris, Muncan, Vanesa, Kemp, Richard, Neufeld, Kristi, Clevers, Hans, Brunton, Valerie, Winton, Douglas J., Wang, Xiaoyan, Sears, Rosalie C., Clarke, Alan R., Frame, Margaret C., Sansom, Owen J.

“…The intestinal epithelium has a remarkable capacity to regenerate after injury and DNA damage. Here, we show that the integrin effector protein Focal Adhesion…”
Get full text

Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc by Muncan, Vanesa, Sansom, Owen J., Tertoolen, Leon, Phesse, Toby J., Begthel, Harry, Sancho, Elena, Cole, Alicia M., Gregorieff, Alex, de Alboran, Ignacio Moreno, Clevers, Hans, Clarke, Alan R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo by Flanagan, Dustin J, Barker, Nick, Nowell, Cameron, Clevers, Hans, Ernst, Matthias, Phesse, Toby J, Vincan, Elizabeth

“…The gastric epithelium consists of tubular glandular units, each containing several differentiated cell types, and populations of stem cells, which enable the…”
Get full text

Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion by Flanagan, Dustin J, Schwab, Renate H M, Tran, Bang M, Phesse, Toby J, Vincan, Elizabeth

“…The discovery of Lgr5 as a marker of adult stem cells meant that stem cell populations could be purified and studied in isolation. Importantly, when cultured…”
Get more information

Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice by Stuart, Emma, Buchert, Michael, Putoczki, Tracy, Thiem, Stefan, Farid, Ryan, Elzer, Joachim, Huszar, Dennis, Waring, Paul M, Phesse, Toby J, Ernst, Matthias

“…Aberrant activation of the latent transcription factor STAT3 and its downstream targets is a common feature of epithelial-derived human cancers, including…”
Get full text

Responding to R-Spondin: Slit2 Potentiates Intestinal Regeneration by Phesse, Toby J., Sansom, Owen J.

“…Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and…”
Get full text

Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer by Turnham, Daniel J, Mullen, Manisha S, Bullock, Nicholas P, Gilroy, Kathryn L, Richards, Anna E, Patel, Radhika, Quintela, Marcos, Meniel, Valerie S, Seaton, Gillian, Kynaston, Howard, Clarkson, Richard W E, Phesse, Toby J, Nelson, Peter S, Haffner, Michael C, Staffurth, John N, Pearson, Helen B

“…As the treatment landscape for prostate cancer gradually evolves, the frequency of treatment-induced neuroendocrine prostate cancer (NEPC) and double-negative…”
Get full text

Wnt Signaling in Cancer: Not a Binary ON:OFF Switch by Flanagan, Dustin J, Vincan, Elizabeth, Phesse, Toby J

“…In the March 1 issue of , we identified the Wnt receptor Fzd7 as an attractive therapeutic target for the treatment of gastric cancer. In summary, we showed…”
Get full text

Myc deletion rescues Apc deficiency in the small intestine by SANSOM, Owen J, MENIEL, Valerie S, MUNCAN, Vanesa, PHESSE, Toby J, WILKINS, Julie A, REED, Karen R, VASS, J. Keith, ATHINEOS, Dimitris, CLEVERS, Hans, CLARKE, Alan R

Get full text

Deficiency of Mbd2 Attenuates Wnt Signaling by Phesse, Toby J., Parry, Lee, Reed, Karen R., Ewan, Kenneth B., Dale, Trevor C., Sansom, Owen J., Clarke, Alan R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers by Flanagan, Dustin J, Vincan, Elizabeth, Phesse, Toby J

“…Gastric cancer persists as a frequent and deadly disease that claims over 700 000 lives annually. Gastric cancer is a multifactorial disease that is…”
Get full text

Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations by Flanagan, Dustin J, Barker, Nick, Costanzo, Natasha S Di, Mason, Elizabeth A, Gurney, Austin, Meniel, Valerie S, Koushyar, Sarah, Austin, Chloe R, Ernst, Matthias, Pearson, Helen B, Boussioutas, Alex, Clevers, Hans, Phesse, Toby J, Vincan, Elizabeth

“…A subset of patients with gastric cancer have mutations in genes that participate in or regulate Wnt signaling at the level of ligand (Wnt) receptor (Fzd)…”
Get full text

Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium by Jardé, Thierry, Chan, Wing Hei, Rossello, Fernando J., Kaur Kahlon, Tanvir, Theocharous, Mandy, Kurian Arackal, Teni, Flores, Tracey, Giraud, Mégane, Richards, Elizabeth, Chan, Eva, Kerr, Genevieve, Engel, Rebekah M., Prasko, Mirsada, Donoghue, Jacqueline F., Abe, Shin-ichi, Phesse, Toby J., Nefzger, Christian M., McMurrick, Paul J., Powell, David R., Daly, Roger J., Polo, Jose M., Abud, Helen E.

“…Epidermal growth factor (EGF) maintains intestinal stem cell (ISC) proliferation and is a key component of organoid growth media yet is dispensable for…”
Get full text