Search Results - "Phelps, M. E."

Brain Glucose Metabolism in Hypothyroidism: A Positron Emission Tomography Study before and after Thyroid Hormone Replacement Therapy by Bauer, M., Silverman, D. H. S., Schlagenhauf, F., London, E. D., Geist, C. L., van Herle, K., Rasgon, N., Martinez, D., Miller, K., van Herle, A., Berman, S. M., Phelps, M. E., Whybrow, P. C.

“…Context: Hypothyroidism is frequently associated with subtle behavioral and psychiatric symptoms. The consequences of inadequate thyroid hormone availability…”
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NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph by Gu, Z, Taschereau, R, Vu, N T, Wang, H, Prout, D L, Silverman, R W, Bai, B, Stout, D B, Phelps, M E, Chatziioannou, A F

“…PETbox4 is a new, fully tomographic bench top PET scanner dedicated to high sensitivity and high resolution imaging of mice. This manuscript characterizes the…”
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PET: The Merging of Biology and Imaging into Molecular Imaging by Phelps, Michael E

“…PET and SPECT are molecular imaging techniques that use radiolabeled molecules to image molecular interactions of biological processes in vivo. PET imaging…”
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A tabulated summary of the FDG PET literature by GAMBHIR, Sanjiv S, CZERNIN, Johannes, SCHWIMMER, Judy, SILVERMAN, Daniel H. S, COLEMAN, R. Edward, PHELPS, Michael E

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Noninvasive Quantitative Imaging of Protein-Protein Interactions in Living Subjects by Ray, P., Pimenta, H., Paulmurugan, R., Berger, F., Phelps, M. E., Iyer, M., Gambhir, S. S.

“…We are developing methods to image molecular and cellular events in living subjects. In this study, we validate imaging of protein-protein interactions in…”
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Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals by MACLAREN, D. C, GAMBHIR, S. S, HERSCHMAN, H. R, SATYAMURTHY, N, BARRIO, J. R, SHARFSTEIN, S, TOYOKUNI, T, WU, L, BERK, A. J, CHERRY, S. R, PHELPS, M. E

“…Reporter genes (e.g. beta-galactosidase, chloramphenicol-acetyltransferase, green fluorescent protein, luciferase) play critical roles in investigating…”
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Analytical decision model for the cost-effective management of solitary pulmonary nodules by Gambhir, S S, Shepherd, J E, Shah, B D, Hart, E, Hoh, C K, Valk, P E, Emi, T, Phelps, M E

“…Multiple strategies are currently being used to manage patients who present with indeterminate solitary pulmonary nodules (SPN). We have used decision-analysis…”
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Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors by YAGHOUBI, S. S, WU, L, LIANG, Q, TOYOKUNI, T, BARRIO, J. R, NAMAVARI, M, SATYAMURTHY, N, PHELPS, M. E, HERSCHMAN, H. R, GAMBHIR, S. S

“…Biodistribution, magnitude and duration of a therapeutic transgene's expression may be assessed by linking it to the expression of a positron emission…”
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A Meta-Analysis of the Literature for Whole-Body FDG PET Detection of Recurrent Colorectal Cancer by Huebner, Ralf H, Park, Kenneth C, Shepherd, James E, Schwimmer, Judy, Czernin, Johannes, Phelps, Michael E, Gambhir, Sanjiv S

“…A meta-analysis of the literature for the use of FDG PET in the detection of recurrent colorectal cancer (CRC) was conducted to evaluate the quality of the…”
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Cerebral hyperglycolysis following severe traumatic brain injury in humans : a positron emission tomography study by BERGSNEIDER, M, HOVDA, D. A, BECKER, D. P, SHALMON, E, KELLY, D. F, VESPA, P. M, MARTIN, N. A, PHELPS, M. E, MCARTHUR, D. L, CARON, M. J, KRAUS, J. F

“…Experimental traumatic brain injury studies have shown that cerebral hyperglycolysis is a pathophysiological response to injury-induced ionic and neurochemical…”
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Quantitative imaging of gene induction in living animals by SUN, X, ANNALA, A. J, GAMBHIR, S. S, YAGHOUBI, S. S, BARRIO, J. R, NGUYEN, K. N, TOYOKUNI, T, SATYAMURTHY, N, NAMAVARI, M, PHELPS, M. E, HERSCHMAN, H. R

“…Methods to repeatedly, non-invasively, and quantitatively image gene expression in living animals are rapidly emerging and should fundamentally change studies…”
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Localized Orbitofrontal and Subcortical Metabolic Changes and Predictors of Response to Paroxetine Treatment in Obsessive-Compulsive Disorder by Saxena, Sanjaya, Brody, Arthur L, Maidment, Karron M, Dunkin, Jennifer J, Colgan, Mark, Alborzian, Shervin, Phelps, Michael E, Baxter, Lewis R

“…Previous positron emission tomography (PET) studies of patients with obsessive-compulsive disorder (OCD) have found elevated glucose metabolic rates in the…”
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Maximal entropy inference of oncogenicity from phosphorylation signaling by Graeber, T.G, Heath, J.R, Skaggs, B.J, Phelps, M.E, Remacle, F, Levine, R.D

“…Point mutations in the phosphorylation domain of the Bcr-Abl fusion oncogene give rise to drug resistance in chronic myelogenous leukemia patients. These…”
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Human Pharmacokinetic and Dosimetry Studies of [18F]FHBG: A Reporter Probe for Imaging Herpes Simplex Virus Type-1 Thymidine Kinase Reporter Gene Expression by Yaghoubi, Shahriar, Barrio, Jorge R, Dahlbom, Magnus, Iyer, Meera, Namavari, Mohammad, Satyamurthy, Nagichettiar, Goldman, Robin, Herschman, Harvey R, Phelps, Michael E, Gambhir, Sanjiv S

“…9-[4-[(18)F]fluoro-3-(hydroxymethyl)butyl]guanine ([(18)F]FHBG) has been used as a reporter probe to image expression of herpes simplex virus type-1 thymidine…”
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Imaging Transgene Expression with Radionuclide Imaging Technologies by Gambhir, S.S., Herschman, H.R., Cherry, S.R., Barrio, J.R., Satyamurthy, N., Toyokuni, T., Phelps, M.E, Larson, S.M., Balatoni, J., Finn, R., Sadelain, M., Tjuvajev, J., Blasbergt, R.

“…A variety of imaging technologies are being investigated as tools for studying gene expression in living subjects. Noninvasive, repetitive and quantitative…”
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Influence of age and hemodynamics on myocardial blood flow and flow reserve by CZERNIN, J, MÜLLER, P, SAMMY CHAN, BRUNKEN, R. C, PORENTA, G, KRIVOKAPICH, J, CHEN, K, CHAN, A, PHELPS, M. E, SCHELBERT, H. R

“…Aging is associated with changes of the systolic blood pressure that may increase cardiac work and myocardial blood flow at rest and reduce the myocardial flow…”
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Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET by Grafton, ST, Mazziotta, JC, Presty, S, Friston, KJ, Frackowiak, RS, Phelps, ME

“…The functional anatomy of motor skill acquisition was investigated in six normal human subjects who learned to perform a pursuit rotor task with their dominant…”
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In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET) by Kornblum, Harley I, Araujo, Dalia M, Annala, Alexander J, Tatsukawa, Keith J, Phelps, Michael E, Cherry, Simon R

“…The study of neural repair and neuroplasticity in rodents would be enhanced by the ability to assess neuronal function in vivo. Positron emission tomography…”
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Imaging of Adenoviral-Directed Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Expression in Mice with Radiolabeled Ganciclovir by Gambhir, Sanjiv S, Barrio, Jorge R, Wu, Lily, Iyer, Meera, Namavari, Mohammad, Satyamurthy, Nagichettiar, Bauer, Eileen, Parrish, Capella, MacLaren, Duncan C, Borghei, Ali R, Green, Leeta A, Sharfstein, Susan, Berk, Arnold J, Cherry, Simon R, Phelps, Michael E, Herschman, Harvey R

“…We are developing procedures to repeatedly and noninvasively image the expression of transplanted reporter genes in living animals and in patients, using PET…”
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Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene by LIANG, Q, NGUYEN, K, SATYAMURTHY, N, BARRIO, J. R, PHELPS, M. E, GAMBHIR, S. S, HERSCHMAN, H. R

“…Current gene therapy protocols often suffer from an inability to monitor the site, level and persistence of gene expression following somatic DNA delivery…”
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