Search Results - "Phelps, Janet R"

Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes by Judge, Adam, McClintock, Kevin, Phelps, Janet R, Maclachlan, Ian

“…The systemic application of nucleic acid drugs requires delivery systems that overcome the poor pharmacokinetics, limited biodistribution, and inefficient…”
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Postexposure Protection of Guinea Pigs against a Lethal Ebola Virus Challenge Is Conferred by RNA Interference by Geisbert, Thomas W., Hensley, Lisa E., Kagan, Elliott, Yu, Erik Zhaoying, Geisbert, Joan B., Daddario-DiCaprio, Kathleen, Fritz, Elizabeth A., Jahrling, Peter B., McClintock, Kevin, Phelps, Janet R., Lee, Amy C. H., Judge, Adam, Jeffs, Lloyd B., MacLachlan, Ian

“…BackgroundEbola virus (EBOV) infection causes a frequently fatal hemorrhagic fever (HF) that is refractory to treatment with currently available antiviral…”
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Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506 by Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Quintero, Jorge G., Yi Fan, Kristi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Phelps, Janet R., Lee, Amy C.H., Thi, Emily P., Chiu, Tim, Tang, Sunny, Horanyi, Peter S., Mayclin, Stephen J., Harasym, Troy O., Sofia, Michael J.

“…[Display omitted] Disruption of the HBV capsid assembly process through small-molecule interaction with HBV core protein is a validated target for the…”
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Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein by Mani, Nagraj, Cole, Andrew G., Phelps, Janet R., Ardzinski, Andrzej, Burns, Robbin, Chiu, Tim, Cuconati, Andrea, Dorsey, Bruce D., Evangelista, Ellen, Fan, Kristi, Guo, Fang, Harasym, Troy O., Kadhim, Salam, Kowalski, Roseann, Kultgen, Steven G., Lee, Amy C.H., Li, Alice H., Majeski, Sara A., Miller, Angela, Pasetka, Chris, Reid, Stephen P., Rijnbrand, Rene, Micolochick Steuer, Holly M., Stever, Kim, Tang, Sunny, Teng, Xiaowei, Wang, Xiaohe, Sofia, Michael J.

“…AB-506, a small-molecule inhibitor targeting the HBV core protein, inhibits viral replication in vitro (HepAD38 cells: EC50 of 0.077 μM, CC50 > 25 μM) and in…”
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The identification of highly efficacious functionalised tetrahydrocyclopenta[]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly by Cole, Andrew G, Kultgen, Steven G, Mani, Nagraj, Ardzinski, Andrzej, Fan, Kristi Yi, Thi, Emily P, Dorsey, Bruce D, Stever, Kim, Chiu, Tim, Tang, Sunny, Daly, Owen, Phelps, Janet R, Harasym, Troy, Olland, Andrea, Suto, Robert K, Sofia, Michael J

“…Disruption of the HBV viral life cycle with small molecules that prevent the encapsidation of pregenomic RNA and viral polymerase through binding to HBV core…”
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ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection by Thi, Emily P, Dhillon, Ammen P, Ardzinski, Andrzej, Bidirici-Ertekin, Lale, Cobarrubias, Kyle D, Cuconati, Andrea, Kondratowicz, Andrew S, Kwak, Kaylyn, Li, Alice H. L, Miller, Angela, Pasetka, Chris, Pei, Luying, Phelps, Janet R, Snead, Nicholas M, Wang, Xiaohe, Ye, Xin, Sofia, Michael J, Lee, Amy C. H

“…Current approved nucleoside analogue treatments for chronic hepatitis B virus (HBV) infection are effective at controlling viral titer but are not curative and…”
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Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation by Mani, Nagraj, Cole, Andrew G, Phelps, Janet R, Ardzinski, Andrzej, Cobarrubias, Kyle D, Cuconati, Andrea, Dorsey, Bruce D, Evangelista, Ellen, Fan, Kristi, Guo, Fang, Guo, Haitao, Guo, Ju-Tao, Harasym, Troy O, Kadhim, Salam, Kultgen, Steven G, Lee, Amy C H, Li, Alice H L, Long, Quanxin, Majeski, Sara A, Mao, Richeng, McClintock, Kevin D, Reid, Stephen P, Rijnbrand, Rene, Snead, Nicholas M, Micolochick Steuer, Holly M, Stever, Kim, Tang, Sunny, Wang, Xiaohe, Zhao, Qiong, Sofia, Michael J

“…AB-423 is a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors in phase 1 clinical trials. In cell culture models,…”
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