Search Results - "Phelps, Doris A"

The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma by Bid, Hemant K, Phelps, Doris A, Xaio, Linlin, Guttridge, Denis C, Lin, Jiayuh, London, Cheryl, Baker, Laurence H, Mo, Xiaokui, Houghton, Peter J

“…The bromodomain and extra-terminal domain inhibitor JQ1 has marked antitumor activity against several hematologic malignancies as well as solid tumor models…”
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Potent inhibition of angiogenesis by the IGF-1 receptor-targeting antibody SCH717454 is reversed by IGF-2 by Bid, Hemant K, Zhan, Jun, Phelps, Doris A, Kurmasheva, Raushan T, Houghton, Peter J

“…Previously, we reported that a predominant action of a type-1 insulin-like growth factor receptor (IGF-1R)-targeted antibody was through inhibiting…”
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Surfaceome Profiling of Rhabdomyosarcoma Reveals B7-H3 as a Mediator of Immune Evasion by Lavoie, Roxane R., Gargollo, Patricio C., Ahmed, Mohamed E., Kim, Yohan, Baer, Emily, Phelps, Doris A., Charlesworth, Cristine M., Madden, Benjamin J., Wang, Liguo, Houghton, Peter J., Cheville, John, Dong, Haidong, Granberg, Candace F., Lucien, Fabrice

“…Novel therapeutic strategies are needed for the treatment of rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children. By using a combination of…”
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Development of a tumor-selective approach to treat metastatic cancer by Aboody, Karen S, Bush, Rebecca A, Garcia, Elizabeth, Metz, Marianne Z, Najbauer, Joseph, Justus, Kristine A, Phelps, Doris A, Remack, Joanna S, Yoon, Karina Jin, Gillespie, Shanna, Kim, Seung U, Glackin, Carlotta A, Potter, Philip M, Danks, Mary K

“…Patients diagnosed with metastatic cancer have almost uniformly poor prognoses. The treatments available for patients with disseminated disease are usually not…”
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ICAM-2 expression mediates a membrane-actin link, confers a nonmetastatic phenotype and reflects favorable tumor stage or histology in neuroblastoma by Yoon, Karina Jin, Phelps, Doris A, Bush, Rebecca A, Remack, Joanna S, Billups, Catherine A, Khoury, Joseph D

“…The actin cytoskeleton is a primary determinant of tumor cell motility and metastatic potential. Motility and metastasis are thought to be regulated, in large…”
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Evaluation of Eribulin Combined with Irinotecan for Treatment of Pediatric Cancer Xenografts by Robles, Andrew J, Kurmasheva, Raushan T, Bandyopadhyay, Abhik, Phelps, Doris A, Erickson, Stephen W, Lai, Zhao, Kurmashev, Dias, Chen, Yidong, Smith, Malcom A, Houghton, Peter J

“…Vincristine combined with camptothecin derivatives showed synergy in preclinical pediatric cancer models, and the combinations are effective in treatment of…”
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Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma by Shackleford, Terry J, Hariharan, Seethalakshmi, Vaseva, Angelina V, Alagoa, Karina, Espinoza, Maricruz, Bid, Hemant K, Li, Fuyang, Zhong, Haihong, Phelps, Doris A, Roberts, Ryan D, Cam, Hakan, London, Cheryl A, Guttridge, Denis C, Chen, Yidong, Rao, Manjeet, Shiio, Yuzuru, Houghton, Peter J

“…Antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) induce objective responses in only 5% to 15% of children with sarcoma. Understanding the…”
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Evaluation of entinostat alone and in combination with standard‐of‐care cytotoxic agents against rhabdomyosarcoma xenograft models by Kurmasheva, Raushan T., Bandyopadhyay, Abhik, Favours, Edward, Del Pozo, Vanessa, Ghilu, Samson, Phelps, Doris A., Erickson, Stephen W., Peer, Cody J., Figg, William D., Smith, Malcolm A., Houghton, Peter J.

“…Background Entinostat, a selective class I histone deacetylase inhibitor, has been reported to enhance the activity of cytotoxic agents and suppress expression…”
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Evaluation of VTP‐50469, a menin‐MLL1 inhibitor, against Ewing sarcoma xenograft models by the pediatric preclinical testing consortium by Kurmasheva, Raushan T., Bandyopadhyay, Abhik, Favours, Edward, Pozo, Vanessa Del, Ghilu, Samson, Phelps, Doris A., McGeehan, Gerard M., Erickson, Stephen W., Smith, Malcolm A., Houghton, Peter J.

“…Background VTP‐50469 is a potent inhibitor of the menin‐MLL1 interaction and is implicated in signaling downstream of EWSR1‐FLI1. Procedure VTP‐50469 was…”
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Development, Characterization, and Reversal of Acquired Resistance to the MEK1 Inhibitor Selumetinib (AZD6244) in an In Vivo Model of Childhood Astrocytoma by BID, Hemant K, KIBLER, Aaron, SMITH, Paul D, KURMASHEVA, Raushan T, XIAOKUI MO, FERNANDEZ, Soledad, HOUGHTON, Peter J, PHELPS, Doris A, MANAP, Sagymbek, LINLIN XIAO, JIAYUH LIN, CAPPER, David, OSWALD, Duane, GEIER, Brian, DEWIRE, Mariko

“…The BT-40 low-grade childhood astrocytoma xenograft model expresses mutated BRAF(V600E) and is highly sensitive to the MEK inhibitor selumetinib (AZD6244). In…”
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Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells by Khoogar, Roxane, Li, Fuyang, Chen, Yidong, Ignatius, Myron, Lawlor, Elizabeth R., Kitagawa, Katsumi, Huang, Tim H.-M., Phelps, Doris A., Houghton, Peter J.

“…Background The EWSR1/FLI1 gene fusion is the most common rearrangement leading to cell transformation in Ewing sarcoma (ES). Previous studies have indicated…”
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IL-6 and CXCL8 mediate osteosarcoma-lung interactions critical to metastasis by Gross, Amy C, Cam, Hakan, Phelps, Doris A, Saraf, Amanda J, Bid, Hemant K, Cam, Maren, London, Cheryl A, Winget, Sarah A, Arnold, Michael A, Brandolini, Laura, Mo, Xiaokui, Hinckley, John M, Houghton, Peter J, Roberts, Ryan D

“…Osteosarcoma (OS), a malignant tumor of bone, kills through aggressive metastatic spread almost exclusively to the lung. Mechanisms driving this tropism for…”
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Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models by Bandyopadhyay, Abhik, Favours, Edward, Phelps, Doris A., Pozo, Vanessa Del, Ghilu, Samson, Kurmashev, Dias, Michalek, Joel, Trevino, Aron, Guttridge, Denis, London, Cheryl, Hirotani, Kenji, Zhang, Ling, Kurmasheva, Raushan T., Houghton, Peter J.

“…Background Integrating molecularly targeted agents with cytotoxic drugs used in curative treatment of pediatric cancers is complex. An evaluation was…”
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Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma by Studebaker, Adam, Bondra, Kathryn, Seum, Star, Shen, Changxian, Phelps, Doris A., Chronowski, Christopher, Leasure, Justin, Smith, Paul D., Kurmasheva, Raushan T., Mo, Xiaokui, Fouladi, Maryam, Houghton, Peter J.

“…Purpose Curative therapy for childhood glioma presents challenges when complete resection is not possible. Patients with recurrent low‐grade tumors or…”
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Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program by Smith, Malcolm A., Morton, Christopher L., Phelps, Doris A., Kolb, E. Anders, Lock, Richard, Carol, Hernan, Reynolds, C. Patrick, Maris, John M., Keir, Stephen T., Wu, Jianrong, Houghton, Peter J.

“…Background Alvespimycin (17‐DMAG, KOS‐1022), a potent small‐molecule inhibitor of the protein chaperone Hsp90, is being developed as an anticancer agent…”
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Abstract 1128: Role of STAT3 in pediatric sarcoma cell lines by Hariharan, Seethalakshmi, Phelps, Doris A., Houghton, Peter J.

“…Abstract Signal transducer and activator of transcription-3 (STAT3) is a transcription factor that plays a major role in embryonic development, cell growth,…”
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Abstract 2775: Development and characterization of a MEK1 inhibitor (AZD6244) sensitive childhood astrocytoma cell line by Studebaker, Adam W., Bid, Hemant K., Phelps, Doris A., Houghton, Peter J.

“…Abstract We previously characterized the development and reversal of acquired resistance to the MEK1 inhibitor AZD6244 in an in vivo model of childhood…”
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Abstract 25: Targeting c-Myc in pediatric sarcoma xenografts with the BET bromodomain inhibitor, JQ1, disrupts angiogenesis by Bid, Hemant Kumar, Phelps, Doris A., Xiao, Linlin, Baker, Laurence, Qi, Jun, Houghton, Peter J.

“…Abstract Histone acetylation regulates activation and repression of multiple angiogenesis and inflammatory genes known to play critical roles in the…”
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Abstract 1614: Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma by Houghton, Peter J., Phelps, Doris A., Bondra, Kathryn, Seum, Star, Chronowski, Christopher, Leasure, Justin, Kurmasheva, Raushan T., Middleton, Stephen, Wang, Dian, Mo, Xiaokui

“…Abstract Curative therapy for childhood sarcoma presents challenges when complete resection is not possible. Ionizing radiation (XRT) is used as a standard…”
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Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma by Phelps, Doris, Bondra, Kathryn, Seum, Star, Chronowski, Christopher, Leasure, Justin, Kurmasheva, Raushan T., Middleton, Steven, Wang, Dian, Mo, Xiaokui, Houghton, Peter J.

“…Background Curative therapy for childhood sarcoma presents challenges when complete resection is not possible. Ionizing radiation (XRT) is used as a standard…”
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