Search Results - "Phelps, Caroline E."
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A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens
Published in Pain (Amsterdam) (01-10-2020)“…Diseases and disorders such as Parkinson disease, schizophrenia, and chronic pain are characterized by altered mesolimbic dopaminergic neurotransmission…”
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Cognition in the Chronic Pain Experience: Preclinical Insights
Published in Trends in cognitive sciences (01-05-2021)“…Acutely, pain is protective. It promotes escape from, and future avoidance of, noxious stimuli through strong and often lifetime associative memories. However,…”
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Chronic Pain Produces Reversible Memory Deficits That Depend on Task Difficulty in Rats
Published in The journal of pain (01-11-2021)“…Cognitive impairment associated with chronic pain remains relatively poorly understood. Use of analgesic drugs and often present co-morbidities in patients can…”
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Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain
Published in Pain (Amsterdam) (01-07-2019)“…Diffuse noxious inhibitory controls (DNICs) is a pain-inhibits-pain phenomenon demonstrated in humans and animals. Diffuse noxious inhibitory control is…”
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The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation
Published in Pain (Amsterdam) (01-03-2021)“…Chronic pain is highly comorbid with affective disorders, including major depressive disorder. A core feature of major depressive disorder is a loss of…”
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Differential Impacts of Healthy Cognitive Aging on Directed and Random Exploration
Published in Psychology and aging (01-02-2024)“…Deciding whether to explore unknown opportunities or exploit well-known options is a ubiquitous part of our everyday lives. Extensive work in college students…”
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Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats
Published in Pain (Amsterdam) (01-07-2018)“…Cognitive flexibility, the ability to adapt behavior to changing outcomes, is critical to survival. The prefrontal cortex is a key site of cognitive control,…”
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