Search Results - "Phay, John"

Heterogeneous parathyroid near‐infrared autofluorescence patterns are associated with single adenomas in primary hyperparathyroidism by Lee, Sang Min, Dedhia, Priya H., Phay, John E.

“…Background Primary adenoma (PA) and multi‐gland hyperplasia (MGH) account for 85% and 15% of primary hyperparathyroidism (PHPT) cases, respectively…”
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A novel optical approach to intraoperative detection of parathyroid glands by McWade, Melanie A., BE, MS, Paras, Constantine, PhD, White, Lisa M., MD, Phay, John E., MD, Mahadevan-Jansen, Anita, PhD, Broome, James T., MD, FACS

“…Background Inadvertent removal of parathyroid glands is a challenge in endocrine operations. There is a critical need for a diagnostic tool that provides…”
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Intraoperative Parathyroid Autofluorescence Detection in Patients with Primary Hyperparathyroidism by Squires, Malcolm H., Jarvis, Rachel, Shirley, Lawrence A., Phay, John E.

“…Background Intrinsic near-infrared (NIR) autofluorescence of the parathyroid gland may improve intraoperative gland identification without the need for…”
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Targeting RET Receptor Tyrosine Kinase Activation in Cancer by PHAY, John E, SHAH, Manisha H

“…After ligand binding induces dimerization, the RET receptor tyrosine kinase activates multiple signal transduction pathways. Constitutively activating…”
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Imaging or Fiber Probe-Based Approach? Assessing Different Methods to Detect Near Infrared Autofluorescence for Intraoperative Parathyroid Identification by Thomas, Giju, Squires, Malcolm H., Metcalf, Tyler, Mahadevan-Jansen, Anita, Phay, John E.

“…Near infrared autofluorescence (NIRAF) can guide intraoperative parathyroid gland (PG) identification. NIRAF detection devices typically rely on imaging and…”
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Smaller parathyroids have higher near-infrared autofluorescence intensity in hyperparathyroidism by Lee, Sang Min, Dedhia, Priya H., Shen, Chengli, Phay, John E.

“…BACKGROUNDIntraoperative parathyroid gland identification can be challenging. Parathyroid glands have an intrinsic autofluorescence when excited by wavelengths…”
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Label-free Intraoperative Parathyroid Localization With Near-Infrared Autofluorescence Imaging by McWade, Melanie A, Paras, Constantine, White, Lisa M, Phay, John E, Solórzano, Carmen C, Broome, James T, Mahadevan-Jansen, Anita

“…Context: The inability to accurately localize the parathyroid glands during parathyroidectomy and thyroidectomy procedures can prevent patients from achieving…”
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Near-infrared autofluorescence for the detection of parathyroid glands by Paras, Constantine, Keller, Matthew, Mahadevan-Jansen, Anita, White, Lisa, Phay, John

“…A major challenge in endocrine surgery is the intraoperative detection of parathyroid glands during both thyroidectomies and parathyroidectomies. Current…”
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The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma by Zaydfudim, Victor, MD, Feurer, Irene D., PhD, Griffin, Marie R., MD, MPH, Phay, John E., MD

“…Background The prognostic role of lymph node metastases in well-differentiated thyroid carcinoma remains controversial. We investigated impact of lymph node…”
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Role of BRAF in Thyroid Oncogenesis by CARONIA, Lisa M, PHAY, John E, SHAH, Manisha H

“…BRAF, a cytoplasmic serine-threonine protein kinase, plays a critical role in cell signaling as an activator within the mitogen-activated protein kinase (MAPK)…”
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ASO Author Reflections: Identification of the Thoracic Duct using Indocyanine Green During Cervical Lymphadenectomy by Chakedis, Jeffery, Phay, John E.

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Update on Pheochromocytoma and Paraganglioma from the SSO Endocrine/Head and Neck Disease-Site Work Group. Part 1 of 2: Advances in Pathogenesis and Diagnosis of Pheochromocytoma and Paraganglioma by Patel, Dhaval, Phay, John E., Yen, Tina W. F., Dickson, Paxton V., Wang, Tracy S., Garcia, Roberto, Yang, Anthony D., Solórzano, Carmen C., Kim, Lawrence T.

“…This first part of a two-part review of pheochromocytoma and paragangliomas (PPGLs) addresses clinical presentation, diagnosis, management, treatment, and…”
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Identification of the Thoracic Duct Using Indocyanine Green During Cervical Lymphadenectomy by Chakedis, Jeffery, Shirley, Lawrence A., Terando, Alicia M., Skoracki, Roman, Phay, John E.

“…Background Injury to the thoracic duct (TD) is the most common complication after a left lateral neck dissection, and it carries a high degree of morbidity…”
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Neoadjuvant dabrafenib and trametinib for functional organ preservation in recurrent BRAF V600E-mutated papillary thyroid cancer by Farlow, Janice L., McCrary, Hilary C., Sipos, Jennifer A., Phay, John E., Konda, Bhavana, Agrawal, Amit

“…•The incidence of locally advanced differentiated thyroid cancer is rising.•Definitive surgery for recurrent advanced cases can cause significant…”
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Developing a Clinical Prototype to Guide Surgeons for Intraoperative Label-Free Identification of Parathyroid Glands in Real Time by Thomas, Giju, McWade, Melanie A, Paras, Constantine, Mannoh, Emmanuel A, Sanders, Melinda E, White, Lisa M, Broome, James T, Phay, John E, Baregamian, Naira, Solórzano, Carmen C, Mahadevan-Jansen, Anita

“…Patients undergoing thyroidectomy may have inadvertent damage or removal of the parathyroid gland(s) due to difficulty in real-time parathyroid identification…”
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Efficacy and safety of near-infrared fluorescence identification of the thoracic duct during left lateral neck dissection by Owusu-Brackett, Nicci, Chakedis, Jeffery M, Dedhia, Priya, Gilliam, Christopher, Agrawal, Amit, Kang, Stephan Y, Old, Matthew, Miller, Barbra S, Phay, John E

“…Thoracic duct leaks occur in up to 5% of left lateral neck dissections. No one imaging modality is routinely used to identify the thoracic duct…”
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The Role of NRG1 in the Predisposition to Papillary Thyroid Carcinoma by He, Huiling, Li, Wei, Liyanarachchi, Sandya, Wang, Yanqiang, Yu, Lianbo, Genutis, Luke K, Maharry, Sophia, Phay, John E, Shen, Rulong, Brock, Pamela, de la Chapelle, Albert

“…Abstract Context Previous genome-wide association studies have shown that single-nucleotide polymorphism (SNP) rs2439302 in chromosome 8p12 is significantly…”
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Features of Cytologically Indeterminate Molecularly Benign Nodules Treated With Surgery by Endo, Mayumi, Porter, Kyle, Long, Clarine, Azaryan, Irina, Phay, John E, Ringel, Matthew D, Sipos, Jennifer A, Nabhan, Fadi

“…Abstract Background Most cytologically indeterminate thyroid nodules (ITNs) with benign molecular testing are not surgically removed. The data on clinical…”
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The Role of Central Neck Lymph Node Dissection in the Management of Papillary Thyroid Cancer by Shirley, Lawrence A, Jones, Natalie B, Phay, John E

“…Papillary thyroid cancer (PTC) is the most common thyroid malignancy, and cervical nodal metastases are frequent at presentation. The most common site for…”
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A Novel Dual AMPK Activator/mTOR Inhibitor Inhibits Thyroid Cancer Cell Growth by Plews, Robert L, Mohd Yusof, Adlina, Wang, Chaojie, Saji, Motoyasu, Zhang, Xiaoli, Chen, Ching-Shih, Ringel, Matthew D, Phay, John E

“…Context: Activated AMP protein kinase (AMPK) is a key regulator of intracellular energy homeostasis and may also function as a tumor suppressor by inhibiting…”
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