Search Results - "Pharoah, Paul P D"

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study by Ali, H Raza, Chlon, Leon, Pharoah, Paul D P, Markowetz, Florian, Caldas, Carlos

“…Immune infiltration of breast tumours is associated with clinical outcome. However, past work has not accounted for the diversity of functionally distinct cell…”
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p53 polymorphisms: cancer implications by Hollstein, Monica, Whibley, Catherine, Pharoah, Paul D. P

“…Key Points TP53 , which encodes p53, is a tumour suppressor gene that is frequently mutated in sporadic cancers. The mutations are usually single base…”
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Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study by Callender, Tom, Emberton, Mark, Morris, Steve, Eeles, Ros, Kote-Jarai, Zsofia, Pharoah, Paul D P, Pashayan, Nora

“…The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69…”
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An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation by Candido Dos Reis, Francisco J, Wishart, Gordon C, Dicks, Ed M, Greenberg, David, Rashbass, Jem, Schmidt, Marjanka K, van den Broek, Alexandra J, Ellis, Ian O, Green, Andrew, Rakha, Emad, Maishman, Tom, Eccles, Diana M, Pharoah, Paul D P

“…PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case…”
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Breast cancer risk factors and their effects on survival: a Mendelian randomisation study by Escala-Garcia, Maria, Morra, Anna, Canisius, Sander, Chang-Claude, Jenny, Kar, Siddhartha, Zheng, Wei, Bojesen, Stig E, Easton, Doug, Pharoah, Paul D P, Schmidt, Marjanka K

“…Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has…”
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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype by Barnett, Gillian C, West, Catherine M. L, Dunning, Alison M, Elliott, Rebecca M, Coles, Charlotte E, Pharoah, Paul D. P, Burnet, Neil G

“…Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to…”
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Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer by James, Fiona R, Jiminez-Linan, Mercedes, Alsop, Jennifer, Mack, Marie, Song, Honglin, Brenton, James D, Pharoah, Paul D P, Ali, H Raza

“…There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption…”
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Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer by Pharoah, Paul D.P, Antoniou, Antonis C, Easton, Douglas F, Ponder, Bruce A.J

“…This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide…”
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Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study by Liou, Lathan, Kaptoge, Stephen, Dennis, Joe, Shah, Mitul, Tyrer, Jonathan, Inouye, Michael, Easton, Douglas F, Pharoah, Paul D P

“…Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing…”
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Risk Factors for the Incidence of Breast Cancer: Do They Affect Survival From the Disease? by BARNETT, Gillian C, SHAH, Mitul, REDMAN, Karen, EASTON, Douglas F, PONDER, Bruce A. J, PHAROAH, Paul D. P

“…Risk factors that influence the incidence of breast cancer may also affect survival after diagnosis. Data from 4,560 women with invasive breast cancer who had…”
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Association studies for finding cancer-susceptibility genetic variants by Ponder, Bruce A. J, Pharoah, Paul D. P, Dunning, Alison M, Easton, Douglas F

“…Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of…”
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Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer by Callagy, Grace M, Webber, Mark J, Pharoah, Paul D P, Caldas, Carlos

“…A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a…”
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The importance of using public data to validate reported associations by Chenevix-Trench, Georgia, Beesley, Jonathan, Pharoah, Paul D P, Berchuck, Andrew

“…About the Authors: Georgia Chenevix-Trench Roles Conceptualization, Writing – original draft * E-mail: georgiaT@qimr.edu.au Affiliation: Queensland Institute…”
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Association between common variation in 120 candidate genes and breast cancer risk by Pharoah, Paul D P, Tyrer, Jonathan, Dunning, Alison M, Easton, Douglas F, Ponder, Bruce A J

“…Association studies in candidate genes have been widely used to search for common low penetrance susceptibility alleles, but few definite associations have…”
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Multiple Loci With Different Cancer Specificities Within the 8q24 Gene Desert by Ghoussaini, Maya, Song, Honglin, Koessler, Thibaud, Al Olama, Ali Amin, Kote-Jarai, Zsofia, Driver, Kristy E., Pooley, Karen A., Ramus, Susan J., Kjaer, Susanne Krüger, Hogdall, Estrid, DiCioccio, Richard A., Whittemore, Alice S., Gayther, Simon A., Giles, Graham G., Guy, Michelle, Edwards, Stephen M., Morrison, Jonathan, Donovan, Jenny L., Hamdy, Freddie C., Dearnaley, David P., Ardern-Jones, Audrey T., Hall, Amanda L., O'Brien, Lynne T., Gehr-Swain, Beatrice N., Wilkinson, Rosemary A., Brown, Paul M., Hopper, John L., Neal, David E., Pharoah, Paul D. P., Ponder, Bruce A. J., Eeles, Rosalind A., Easton, Douglas F., Dunning, Alison M.

“…Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with…”
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Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model by Pashayan, Nora, Morris, Steve, Gilbert, Fiona J, Pharoah, Paul D P

“…The age-based or "one-size-fits-all" breast screening approach does not take into account the individual variation in risk. Mammography screening reduces death…”
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Independent validation of genes and polymorphisms reported to be associated with radiation toxicity: a prospective analysis study by Barnett, Gillian C, Dr, Coles, Charlotte E, PhD, Elliott, Rebecca M, MRes, Baynes, Caroline, Luccarini, Craig, BSc, Conroy, Don, Wilkinson, Jennifer S, BSc, Tyrer, Jonathan, PhD, Misra, Vivek, MB BS, Platte, Radka, BSc, Gulliford, Sarah L, PhD, Sydes, Matthew R, MSc, Hall, Emma, PhD, Bentzen, Søren M, Prof, Dearnaley, David P, Prof, Burnet, Neil G, PhD, Pharoah, Paul DP, PhD, Dunning, Alison M, PhD, West, Catharine ML, Prof

“…Summary Background Several studies have reported associations between radiation toxicity and single nucleotide polymorphisms (SNPs) in candidate genes. Few…”
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Ovarian Cancer Risk Associated with Inherited Inflammation-Related Variants by WHITE, Kristin L, SCHILDKRAUT, Joellen M, BIRRER, Michael J, PHAROAH, Paul P. D, HONGLIN SONG, TYRER, Jonathan, GAYTHER, Simon A, RAMUS, Susan J, WENTZENSEN, Nicolas, YANG, Hannah P, GARCIA-CLOSAS, Montserrat, PHELAN, Catherine M, PALMIERI, Rachel T, CUNNINGHAM, Julie M, FRIDLEY, Brooke L, SELLERS, Thomas A, GOODE, Ellen L, IVERSEN, Edwin S, BERCHUCK, Andrew, VIERKANT, Robert A, RIDER, David N, CHARBONNEAU, Bridget, CICEK, Mine S, SUTPHEN, Rebecca

“…The importance of inflammation pathways to the development of many human cancers prompted us to examine the associations between single-nucleotide…”
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The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study by Dorling, Leila, Kar, Siddhartha, Michailidou, Kyriaki, Hiller, Louise, Vallier, Anne-Laure, Ingle, Susan, Hardy, Richard, Bowden, Sarah J, Dunn, Janet A, Twelves, Chris, Poole, Christopher J, Caldas, Carlos, Earl, Helena M, Pharoah, Paul D P, Abraham, Jean E

“…Ninety-four common genetic variants are confirmed to be associated with breast cancer. This study tested the hypothesis that breast cancer susceptibility…”
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Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women by Manchanda, Ranjit, Patel, Shreeya, Gordeev, Vladimir S, Antoniou, Antonis C, Smith, Shantel, Lee, Andrew, Hopper, John L, MacInnis, Robert J, Turnbull, Clare, Ramus, Susan J, Gayther, Simon A, Pharoah, Paul D P, Menon, Usha, Jacobs, Ian, Legood, Rosa

“…The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We…”
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