Search Results - "Pharoah, Paul D."

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study by Ali, H Raza, Chlon, Leon, Pharoah, Paul D P, Markowetz, Florian, Caldas, Carlos

“…Immune infiltration of breast tumours is associated with clinical outcome. However, past work has not accounted for the diversity of functionally distinct cell…”
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p53 polymorphisms: cancer implications by Hollstein, Monica, Whibley, Catherine, Pharoah, Paul D. P

“…Key Points TP53 , which encodes p53, is a tumour suppressor gene that is frequently mutated in sporadic cancers. The mutations are usually single base…”
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Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model by Pashayan, Nora, Morris, Steve, Gilbert, Fiona J, Pharoah, Paul D P

“…The age-based or "one-size-fits-all" breast screening approach does not take into account the individual variation in risk. Mammography screening reduces death…”
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Multi-omic machine learning predictor of breast cancer therapy response by Sammut, Stephen-John, Crispin-Ortuzar, Mireia, Chin, Suet-Feung, Provenzano, Elena, Bardwell, Helen A., Ma, Wenxin, Cope, Wei, Dariush, Ali, Dawson, Sarah-Jane, Abraham, Jean E., Dunn, Janet, Hiller, Louise, Thomas, Jeremy, Cameron, David A., Bartlett, John M. S., Hayward, Larry, Pharoah, Paul D., Markowetz, Florian, Rueda, Oscar M., Earl, Helena M., Caldas, Carlos

“…Breast cancers are complex ecosystems of malignant cells and the tumour microenvironment 1 . The composition of these tumour ecosystems and interactions within…”
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Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups by Rueda, Oscar M., Sammut, Stephen-John, Seoane, Jose A., Chin, Suet-Feung, Caswell-Jin, Jennifer L., Callari, Maurizio, Batra, Rajbir, Pereira, Bernard, Bruna, Alejandra, Ali, H. Raza, Provenzano, Elena, Liu, Bin, Parisien, Michelle, Gillett, Cheryl, McKinney, Steven, Green, Andrew R., Murphy, Leigh, Purushotham, Arnie, Ellis, Ian O., Pharoah, Paul D., Rueda, Cristina, Aparicio, Samuel, Caldas, Carlos, Curtis, Christina

“…The rates and routes of lethal systemic spread in breast cancer are poorly understood owing to a lack of molecularly characterized patient cohorts with…”
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Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study by Callender, Tom, Emberton, Mark, Morris, Steve, Eeles, Ros, Kote-Jarai, Zsofia, Pharoah, Paul D P, Pashayan, Nora

“…The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69…”
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An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation by Candido Dos Reis, Francisco J, Wishart, Gordon C, Dicks, Ed M, Greenberg, David, Rashbass, Jem, Schmidt, Marjanka K, van den Broek, Alexandra J, Ellis, Ian O, Green, Andrew, Rakha, Emad, Maishman, Tom, Eccles, Diana M, Pharoah, Paul D P

“…PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case…”
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Evaluation and comparison of different breast cancer prognosis scores based on gene expression data by Chowdhury, Avirup, Pharoah, Paul D, Rueda, Oscar M

“…Breast cancer is one of the three most common cancers worldwide and is the most common malignancy in women. Treatment approaches for breast cancer are diverse…”
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Breast cancer risk factors and their effects on survival: a Mendelian randomisation study by Escala-Garcia, Maria, Morra, Anna, Canisius, Sander, Chang-Claude, Jenny, Kar, Siddhartha, Zheng, Wei, Bojesen, Stig E, Easton, Doug, Pharoah, Paul D P, Schmidt, Marjanka K

“…Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has…”
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Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer by Pharoah, Paul D.P, Antoniou, Antonis C, Easton, Douglas F, Ponder, Bruce A.J

“…This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide…”
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Polygenic scores in cancer by Yang, Xin, Kar, Siddhartha, Antoniou, Antonis C., Pharoah, Paul D. P.

“…Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer…”
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Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies by Blows, Fiona M, Driver, Kristy E, Schmidt, Marjanka K, Broeks, Annegien, van Leeuwen, Flora E, Wesseling, Jelle, Cheang, Maggie C, Gelmon, Karen, Nielsen, Torsten O, Blomqvist, Carl, Heikkilä, Päivi, Heikkinen, Tuomas, Nevanlinna, Heli, Akslen, Lars A, Bégin, Louis R, Foulkes, William D, Couch, Fergus J, Wang, Xianshu, Cafourek, Vicky, Olson, Janet E, Baglietto, Laura, Giles, Graham G, Severi, Gianluca, McLean, Catriona A, Southey, Melissa C, Rakha, Emad, Green, Andrew R, Ellis, Ian O, Sherman, Mark E, Lissowska, Jolanta, Anderson, William F, Cox, Angela, Cross, Simon S, Reed, Malcolm W R, Provenzano, Elena, Dawson, Sarah-Jane, Dunning, Alison M, Humphreys, Manjeet, Easton, Douglas F, García-Closas, Montserrat, Caldas, Carlos, Pharoah, Paul D, Huntsman, David

“…Immunohistochemical markers are often used to classify breast cancer into subtypes that are biologically distinct and behave differently. The aim of this study…”
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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype by Barnett, Gillian C, West, Catherine M. L, Dunning, Alison M, Elliott, Rebecca M, Coles, Charlotte E, Pharoah, Paul D. P, Burnet, Neil G

“…Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to…”
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Genome-wide association study identifies five new breast cancer susceptibility loci by Turnbull, Clare, Ahmed, Shahana, Morrison, Jonathan, Pernet, David, Renwick, Anthony, Maranian, Mel, Seal, Sheila, Ghoussaini, Maya, Hines, Sarah, Healey, Catherine S, Hughes, Deborah, Warren-Perry, Margaret, Tapper, William, Eccles, Diana, Evans, D Gareth, Hooning, Maartje, Schutte, Mieke, van den Ouweland, Ans, Houlston, Richard, Ross, Gillian, Langford, Cordelia, Pharoah, Paul D P, Stratton, Michael R, Dunning, Alison M, Rahman, Nazneen, Easton, Douglas F

“…Douglas Easton and colleagues report a genome-wide association study for breast cancer, identifying five new susceptibility loci. Breast cancer is the most…”
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The prognostic significance of lymphovascular invasion in invasive breast carcinoma by Rakha, Emad A., Martin, Stewart, Lee, Andrew H. S., Morgan, David, Pharoah, Paul D. P., Hodi, Zsolt, MacMillan, Douglas, Ellis, Ian O.

“…BACKGROUND: Although lymphovascular invasion (LVI) has been associated with a poor outcome in patients with breast cancer, it is not included in most…”
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Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond by Hansford, Samantha, Kaurah, Pardeep, Li-Chang, Hector, Woo, Michelle, Senz, Janine, Pinheiro, Hugo, Schrader, Kasmintan A, Schaeffer, David F, Shumansky, Karey, Zogopoulos, George, Santos, Teresa Almeida, Claro, Isabel, Carvalho, Joana, Nielsen, Cydney, Padilla, Sarah, Lum, Amy, Talhouk, Aline, Baker-Lange, Katie, Richardson, Sue, Lewis, Ivy, Lindor, Noralane M, Pennell, Erin, MacMillan, Andree, Fernandez, Bridget, Keller, Gisella, Lynch, Henry, Shah, Sohrab P, Guilford, Parry, Gallinger, Steven, Corso, Giovanni, Roviello, Franco, Caldas, Carlos, Oliveira, Carla, Pharoah, Paul D P, Huntsman, David G

“…E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates…”
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Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk by Easton, Douglas F, Pharoah, Paul D.P, Antoniou, Antonis C, Tischkowitz, Marc, Tavtigian, Sean V, Nathanson, Katherine L, Devilee, Peter, Meindl, Alfons, Couch, Fergus J, Southey, Melissa, Goldgar, David E, Evans, D. Gareth R, Chenevix-Trench, Georgia, Rahman, Nazneen, Robson, Mark, Domchek, Susan M, Foulkes, William D

“…An international group of cancer geneticists review the level of evidence for the association of gene variants with the risk of breast cancer. It is difficult…”
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Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer by James, Fiona R, Jiminez-Linan, Mercedes, Alsop, Jennifer, Mack, Marie, Song, Honglin, Brenton, James D, Pharoah, Paul D P, Ali, H Raza

“…There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption…”
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Individual prognosis at diagnosis in nonmetastatic prostate cancer: Development and external validation of the PREDICT Prostate multivariable model by Thurtle, David R, Greenberg, David C, Lee, Lui S, Huang, Hong H, Pharoah, Paul D, Gnanapragasam, Vincent J

“…Prognostic stratification is the cornerstone of management in nonmetastatic prostate cancer (PCa). However, existing prognostic models are inadequate-often…”
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Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer by Abubakar, Mustapha, Figueroa, Jonine, Ali, H. Raza, Blows, Fiona, Lissowska, Jolanta, Caldas, Carlos, Easton, Douglas F., Sherman, Mark E., Garcia-Closas, Montserrat, Dowsett, Mitch, Pharoah, Paul D.

“…Although most women with luminal breast cancer do well on endocrine therapy alone, some will develop fatal recurrence thereby necessitating the need to…”
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