Search Results - "Pharoah, Paul"

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study by Ali, H Raza, Chlon, Leon, Pharoah, Paul D P, Markowetz, Florian, Caldas, Carlos

“…Immune infiltration of breast tumours is associated with clinical outcome. However, past work has not accounted for the diversity of functionally distinct cell…”
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p53 polymorphisms: cancer implications by Hollstein, Monica, Whibley, Catherine, Pharoah, Paul D. P

“…Key Points TP53 , which encodes p53, is a tumour suppressor gene that is frequently mutated in sporadic cancers. The mutations are usually single base…”
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The challenge of early detection in cancer by Pashayan, Nora, Pharoah, Paul D P

“…Tumor growth dynamics and the timing of metastasis impose limits on cancer screening The chances of survival for a patient with cancer are substantially…”
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Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk by Easton, Douglas F, Pharoah, Paul D.P, Antoniou, Antonis C, Tischkowitz, Marc, Tavtigian, Sean V, Nathanson, Katherine L, Devilee, Peter, Meindl, Alfons, Couch, Fergus J, Southey, Melissa, Goldgar, David E, Evans, D. Gareth R, Chenevix-Trench, Georgia, Rahman, Nazneen, Robson, Mark, Domchek, Susan M, Foulkes, William D

“…An international group of cancer geneticists review the level of evidence for the association of gene variants with the risk of breast cancer. It is difficult…”
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Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model by Pashayan, Nora, Morris, Steve, Gilbert, Fiona J, Pharoah, Paul D P

“…The age-based or "one-size-fits-all" breast screening approach does not take into account the individual variation in risk. Mammography screening reduces death…”
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Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study by Callender, Tom, Emberton, Mark, Morris, Steve, Eeles, Ros, Kote-Jarai, Zsofia, Pharoah, Paul D P, Pashayan, Nora

“…The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69…”
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Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer by Pharoah, Paul D.P, Antoniou, Antonis C, Easton, Douglas F, Ponder, Bruce A.J

“…This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide…”
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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype by Barnett, Gillian C, West, Catherine M. L, Dunning, Alison M, Elliott, Rebecca M, Coles, Charlotte E, Pharoah, Paul D. P, Burnet, Neil G

“…Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to…”
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Genome-wide association study identifies five new breast cancer susceptibility loci by Turnbull, Clare, Ahmed, Shahana, Morrison, Jonathan, Pernet, David, Renwick, Anthony, Maranian, Mel, Seal, Sheila, Ghoussaini, Maya, Hines, Sarah, Healey, Catherine S, Hughes, Deborah, Warren-Perry, Margaret, Tapper, William, Eccles, Diana, Evans, D Gareth, Hooning, Maartje, Schutte, Mieke, van den Ouweland, Ans, Houlston, Richard, Ross, Gillian, Langford, Cordelia, Pharoah, Paul D P, Stratton, Michael R, Dunning, Alison M, Rahman, Nazneen, Easton, Douglas F

“…Douglas Easton and colleagues report a genome-wide association study for breast cancer, identifying five new susceptibility loci. Breast cancer is the most…”
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An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation by Candido Dos Reis, Francisco J, Wishart, Gordon C, Dicks, Ed M, Greenberg, David, Rashbass, Jem, Schmidt, Marjanka K, van den Broek, Alexandra J, Ellis, Ian O, Green, Andrew, Rakha, Emad, Maishman, Tom, Eccles, Diana M, Pharoah, Paul D P

“…PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case…”
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PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer by Wishart, Gordon C, Azzato, Elizabeth M, Greenberg, David C, Rashbass, Jem, Kearins, Olive, Lawrence, Gill, Caldas, Carlos, Pharoah, Paul D P

“…The aim of this study was to develop and validate a prognostication model to predict overall and breast cancer specific survival for women treated for early…”
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Polygenic scores in cancer by Yang, Xin, Kar, Siddhartha, Antoniou, Antonis C., Pharoah, Paul D. P.

“…Since the publication of the first genome-wide association study for cancer in 2007, thousands of common alleles that are associated with the risk of cancer…”
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Breast cancer risk factors and their effects on survival: a Mendelian randomisation study by Escala-Garcia, Maria, Morra, Anna, Canisius, Sander, Chang-Claude, Jenny, Kar, Siddhartha, Zheng, Wei, Bojesen, Stig E, Easton, Doug, Pharoah, Paul D P, Schmidt, Marjanka K

“…Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has…”
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Evidence of a Causal Association Between Cancer and Alzheimer’s Disease: a Mendelian Randomization Analysis by Seddighi, Sahba, Houck, Alexander L., Rowe, James B., Pharoah, Paul D. P.

“…While limited observational evidence suggests that cancer survivors have a decreased risk of developing Alzheimer’s disease (AD), and vice versa, it is not…”
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Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women by Manchanda, Ranjit, Patel, Shreeya, Gordeev, Vladimir S, Antoniou, Antonis C, Smith, Shantel, Lee, Andrew, Hopper, John L, MacInnis, Robert J, Turnbull, Clare, Ramus, Susan J, Gayther, Simon A, Pharoah, Paul D P, Menon, Usha, Jacobs, Ian, Legood, Rosa

“…The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We…”
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The prognostic significance of lymphovascular invasion in invasive breast carcinoma by Rakha, Emad A., Martin, Stewart, Lee, Andrew H. S., Morgan, David, Pharoah, Paul D. P., Hodi, Zsolt, MacMillan, Douglas, Ellis, Ian O.

“…BACKGROUND: Although lymphovascular invasion (LVI) has been associated with a poor outcome in patients with breast cancer, it is not included in most…”
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Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond by Hansford, Samantha, Kaurah, Pardeep, Li-Chang, Hector, Woo, Michelle, Senz, Janine, Pinheiro, Hugo, Schrader, Kasmintan A, Schaeffer, David F, Shumansky, Karey, Zogopoulos, George, Santos, Teresa Almeida, Claro, Isabel, Carvalho, Joana, Nielsen, Cydney, Padilla, Sarah, Lum, Amy, Talhouk, Aline, Baker-Lange, Katie, Richardson, Sue, Lewis, Ivy, Lindor, Noralane M, Pennell, Erin, MacMillan, Andree, Fernandez, Bridget, Keller, Gisella, Lynch, Henry, Shah, Sohrab P, Guilford, Parry, Gallinger, Steven, Corso, Giovanni, Roviello, Franco, Caldas, Carlos, Oliveira, Carla, Pharoah, Paul D P, Huntsman, David G

“…E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates…”
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Multi-omic machine learning predictor of breast cancer therapy response by Sammut, Stephen-John, Crispin-Ortuzar, Mireia, Chin, Suet-Feung, Provenzano, Elena, Bardwell, Helen A., Ma, Wenxin, Cope, Wei, Dariush, Ali, Dawson, Sarah-Jane, Abraham, Jean E., Dunn, Janet, Hiller, Louise, Thomas, Jeremy, Cameron, David A., Bartlett, John M. S., Hayward, Larry, Pharoah, Paul D., Markowetz, Florian, Rueda, Oscar M., Earl, Helena M., Caldas, Carlos

“…Breast cancers are complex ecosystems of malignant cells and the tumour microenvironment 1 . The composition of these tumour ecosystems and interactions within…”
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Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer by Callagy, Grace M, Webber, Mark J, Pharoah, Paul D P, Caldas, Carlos

“…A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a…”
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Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer by James, Fiona R, Jiminez-Linan, Mercedes, Alsop, Jennifer, Mack, Marie, Song, Honglin, Brenton, James D, Pharoah, Paul D P, Ali, H Raza

“…There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption…”
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