Search Results - "Pharoah, P. D. P"

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study by Ali, H Raza, Chlon, Leon, Pharoah, Paul D P, Markowetz, Florian, Caldas, Carlos

“…Immune infiltration of breast tumours is associated with clinical outcome. However, past work has not accounted for the diversity of functionally distinct cell…”
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The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population by Song, Honglin, Cicek, Mine S, Dicks, Ed, Harrington, Patricia, Ramus, Susan J, Cunningham, Julie M, Fridley, Brooke L, Tyrer, Jonathan P, Alsop, Jennifer, Jimenez-Linan, Mercedes, Gayther, Simon A, Goode, Ellen L, Pharoah, Paul D P

“…The aim of this study was to estimate the contribution of deleterious mutations in BRCA1, BRCA2, MLH1, MSH2, MSH6 and PMS2 to invasive epithelial ovarian…”
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Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study by Callender, Tom, Emberton, Mark, Morris, Steve, Eeles, Ros, Kote-Jarai, Zsofia, Pharoah, Paul D P, Pashayan, Nora

“…The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69…”
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p53 polymorphisms: cancer implications by Hollstein, Monica, Whibley, Catherine, Pharoah, Paul D. P

“…Key Points TP53 , which encodes p53, is a tumour suppressor gene that is frequently mutated in sporadic cancers. The mutations are usually single base…”
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An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation by Candido Dos Reis, Francisco J, Wishart, Gordon C, Dicks, Ed M, Greenberg, David, Rashbass, Jem, Schmidt, Marjanka K, van den Broek, Alexandra J, Ellis, Ian O, Green, Andrew, Rakha, Emad, Maishman, Tom, Eccles, Diana M, Pharoah, Paul D P

“…PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case…”
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Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients by Ali, H.R., Provenzano, E., Dawson, S.-J., Blows, F.M., Liu, B., Shah, M., Earl, H.M., Poole, C.J., Hiller, L., Dunn, J.A., Bowden, S.J., Twelves, C., Bartlett, J.M.S., Mahmoud, S.M.A., Rakha, E., Ellis, I.O., Liu, S., Gao, D., Nielsen, T.O., Pharoah, P.D.P., Caldas, C.

“…T-cell infiltration in estrogen receptor (ER)-negative breast tumours has been associated with longer survival. To investigate this association and the…”
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Breast cancer risk factors and their effects on survival: a Mendelian randomisation study by Escala-Garcia, Maria, Morra, Anna, Canisius, Sander, Chang-Claude, Jenny, Kar, Siddhartha, Zheng, Wei, Bojesen, Stig E, Easton, Doug, Pharoah, Paul D P, Schmidt, Marjanka K

“…Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has…”
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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype by Barnett, Gillian C, West, Catherine M. L, Dunning, Alison M, Elliott, Rebecca M, Coles, Charlotte E, Pharoah, Paul D. P, Burnet, Neil G

“…Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to…”
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Association between tumour infiltrating lymphocytes, histotype and clinical outcome in epithelial ovarian cancer by James, Fiona R, Jiminez-Linan, Mercedes, Alsop, Jennifer, Mack, Marie, Song, Honglin, Brenton, James D, Pharoah, Paul D P, Ali, H Raza

“…There is evidence that some ovarian tumours evoke an immune response, which can be assessed by tumour infiltrating lymphocytes (TILs). To facilitate adoption…”
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Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript by Kote-Jarai, Z., Amin Al Olama, A., Leongamornlert, D., Tymrakiewicz, M., Saunders, E., Guy, M., Giles, G. G., Severi, G., Southey, M., Hopper, J. L., Sit, K. C., Harris, J. M., Batra, J., Spurdle, A. B., Clements, J. A., Hamdy, F., Neal, D., Donovan, J., Muir, K., Pharoah, P. D. P., Chanock, S. J., Brown, N., Benlloch, S., Castro, E., Mahmud, N., O’Brien, L., Hall, A., Sawyer, E., Wilkinson, R., Easton, D. F., Eeles, R. A.

“…Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa) susceptibility loci. One of these (rs2735839) is located close to a…”
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The BOADICEA model of genetic susceptibility to breast and ovarian cancer by ANTONIOU, A. C, PHAROAH, P. P. D, SMITH, P, EASTON, D. F

“…Several genes conferring susceptibility to breast and ovarian cancer, notably BRCA1 and BRCA2, have been identified. The majority of the familial aggregation…”
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Clinical Characteristics of Ovarian Cancer Classified by BRCA1, BRCA2 and RAD51C Status by Cunningham, J. M., Cicek, M. S., Larson, N. B., Davila, J., Wang, C., Larson, M. C., Song, H., Dicks, E. M., Harrington, P., Wick, M., Winterhoff, B. J., Hamidi, H., Konecny, G. E., Chien, J., Bibikova, M., Fan, J.-B., Kalli, K. R., Lindor, N. M., Fridley, B. L., Pharoah, P. P. D., Goode, E. L.

“…We evaluated homologous recombination deficient (HRD) phenotypes in epithelial ovarian cancer (EOC) considering BRCA1 , BRCA2 and RAD51C in a large…”
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Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer by Pharoah, Paul D.P, Antoniou, Antonis C, Easton, Douglas F, Ponder, Bruce A.J

“…This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide…”
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Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study by Liou, Lathan, Kaptoge, Stephen, Dennis, Joe, Shah, Mitul, Tyrer, Jonathan, Inouye, Michael, Easton, Douglas F, Pharoah, Paul D P

“…Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing…”
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Risk Factors for the Incidence of Breast Cancer: Do They Affect Survival From the Disease? by BARNETT, Gillian C, SHAH, Mitul, REDMAN, Karen, EASTON, Douglas F, PONDER, Bruce A. J, PHAROAH, Paul D. P

“…Risk factors that influence the incidence of breast cancer may also affect survival after diagnosis. Data from 4,560 women with invasive breast cancer who had…”
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Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics by Antoniou, A C, Hardy, R, Walker, L, Evans, D G, Shenton, A, Eeles, R, Shanley, S, Pichert, G, Izatt, L, Rose, S, Douglas, F, Eccles, D, Morrison, P J, Scott, J, Zimmern, R L, Easton, D F, Pharoah, P D P

“…Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 has important implications for the clinical management of people found…”
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Aurora kinase A outperforms Ki67 as a prognostic marker in ER-positive breast cancer by Ali, H R, Dawson, S-J, Blows, F M, Provenzano, E, Pharoah, P D, Caldas, C

“…Background: Proliferation has emerged as a major prognostic factor in luminal breast cancer. The immunohistochemical (IHC) proliferation marker Ki67 has been…”
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The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions by Antoniou, A C, Cunningham, A P, Peto, J, Evans, D G, Lalloo, F, Narod, S A, Risch, H A, Eyfjord, J E, Hopper, J L, Southey, M C, Olsson, H, Johannsson, O, Borg, A, Passini, B, Radice, P, Manoukian, S, Eccles, D M, Tang, N, Olah, E, Anton-Culver, H, Warner, E, Lubinski, J, Gronwald, J, Gorski, B, Tryggvadottir, L, Syrjakoski, K, Kallioniemi, O-P, Eerola, H, Nevanlinna, H, Pharoah, P D P, Easton, D F

“…Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast…”
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Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer by Callagy, Grace M, Webber, Mark J, Pharoah, Paul D P, Caldas, Carlos

“…A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a…”
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Association studies for finding cancer-susceptibility genetic variants by Ponder, Bruce A. J, Pharoah, Paul D. P, Dunning, Alison M, Easton, Douglas F

“…Cancer is the result of complex interactions between inherited and environmental factors. Known genes account for a small proportion of the heritability of…”
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