Search Results - "Pharoah, P."

Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study by Ali, H Raza, Chlon, Leon, Pharoah, Paul D P, Markowetz, Florian, Caldas, Carlos

“…Immune infiltration of breast tumours is associated with clinical outcome. However, past work has not accounted for the diversity of functionally distinct cell…”
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Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients by Ali, H.R., Provenzano, E., Dawson, S.-J., Blows, F.M., Liu, B., Shah, M., Earl, H.M., Poole, C.J., Hiller, L., Dunn, J.A., Bowden, S.J., Twelves, C., Bartlett, J.M.S., Mahmoud, S.M.A., Rakha, E., Ellis, I.O., Liu, S., Gao, D., Nielsen, T.O., Pharoah, P.D.P., Caldas, C.

“…T-cell infiltration in estrogen receptor (ER)-negative breast tumours has been associated with longer survival. To investigate this association and the…”
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Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic by Sud, A., Jones, M.E., Broggio, J., Loveday, C., Torr, B., Garrett, A., Nicol, D.L., Jhanji, S., Boyce, S.A., Gronthoud, F., Ward, P., Handy, J.M., Yousaf, N., Larkin, J., Suh, Y-E., Scott, S., Pharoah, P.D.P., Swanton, C., Abbosh, C., Williams, M., Lyratzopoulos, G., Houlston, R., Turnbull, C.

“…Cancer diagnostics and surgery have been disrupted by the response of health care services to the coronavirus disease 2019 (COVID-19) pandemic. Progression of…”
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PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes by Ali, H.R., Glont, S.-E., Blows, F.M., Provenzano, E., Dawson, S.-J., Liu, B., Hiller, L., Dunn, J., Poole, C.J., Bowden, S., Earl, H.M., Pharoah, P.D.P., Caldas, C.

“…Expression of programmed death ligand 1 (PD-L1) in solid tumours has been shown to predict whether patients are likely to respond to anti-PD-L1 therapies. To…”
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The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population by Song, Honglin, Cicek, Mine S, Dicks, Ed, Harrington, Patricia, Ramus, Susan J, Cunningham, Julie M, Fridley, Brooke L, Tyrer, Jonathan P, Alsop, Jennifer, Jimenez-Linan, Mercedes, Gayther, Simon A, Goode, Ellen L, Pharoah, Paul D P

“…The aim of this study was to estimate the contribution of deleterious mutations in BRCA1, BRCA2, MLH1, MSH2, MSH6 and PMS2 to invasive epithelial ovarian…”
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Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript by Kote-Jarai, Z., Amin Al Olama, A., Leongamornlert, D., Tymrakiewicz, M., Saunders, E., Guy, M., Giles, G. G., Severi, G., Southey, M., Hopper, J. L., Sit, K. C., Harris, J. M., Batra, J., Spurdle, A. B., Clements, J. A., Hamdy, F., Neal, D., Donovan, J., Muir, K., Pharoah, P. D. P., Chanock, S. J., Brown, N., Benlloch, S., Castro, E., Mahmud, N., O’Brien, L., Hall, A., Sawyer, E., Wilkinson, R., Easton, D. F., Eeles, R. A.

“…Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa) susceptibility loci. One of these (rs2735839) is located close to a…”
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Polygenic risk-tailored screening for prostate cancer: A benefit-harm and cost-effectiveness modelling study by Callender, Tom, Emberton, Mark, Morris, Steve, Eeles, Ros, Kote-Jarai, Zsofia, Pharoah, Paul D P, Pashayan, Nora

“…The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69…”
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The BOADICEA model of genetic susceptibility to breast and ovarian cancer by ANTONIOU, A. C, PHAROAH, P. P. D, SMITH, P, EASTON, D. F

“…Several genes conferring susceptibility to breast and ovarian cancer, notably BRCA1 and BRCA2, have been identified. The majority of the familial aggregation…”
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An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation by Candido Dos Reis, Francisco J, Wishart, Gordon C, Dicks, Ed M, Greenberg, David, Rashbass, Jem, Schmidt, Marjanka K, van den Broek, Alexandra J, Ellis, Ian O, Green, Andrew, Rakha, Emad, Maishman, Tom, Eccles, Diana M, Pharoah, Paul D P

“…PREDICT is a breast cancer prognostic and treatment benefit model implemented online. The overall fit of the model has been good in multiple independent case…”
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The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions by Antoniou, A C, Cunningham, A P, Peto, J, Evans, D G, Lalloo, F, Narod, S A, Risch, H A, Eyfjord, J E, Hopper, J L, Southey, M C, Olsson, H, Johannsson, O, Borg, A, Passini, B, Radice, P, Manoukian, S, Eccles, D M, Tang, N, Olah, E, Anton-Culver, H, Warner, E, Lubinski, J, Gronwald, J, Gorski, B, Tryggvadottir, L, Syrjakoski, K, Kallioniemi, O-P, Eerola, H, Nevanlinna, H, Pharoah, P D P, Easton, D F

“…Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast…”
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Clinical Characteristics of Ovarian Cancer Classified by BRCA1, BRCA2 and RAD51C Status by Cunningham, J. M., Cicek, M. S., Larson, N. B., Davila, J., Wang, C., Larson, M. C., Song, H., Dicks, E. M., Harrington, P., Wick, M., Winterhoff, B. J., Hamidi, H., Konecny, G. E., Chien, J., Bibikova, M., Fan, J.-B., Kalli, K. R., Lindor, N. M., Fridley, B. L., Pharoah, P. P. D., Goode, E. L.

“…We evaluated homologous recombination deficient (HRD) phenotypes in epithelial ovarian cancer (EOC) considering BRCA1 , BRCA2 and RAD51C in a large…”
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Meta-analysis of the association between emphysematous change on thoracic computerized tomography scan and recurrent pneumothorax by Girish, M, Pharoah, P D, Marciniak, S J

“…Summary Objectives At least a third of patients go on to suffer a recurrence following a first spontaneous pneumothorax. Surgical intervention reduces the risk…”
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Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women by Manchanda, Ranjit, Patel, Shreeya, Gordeev, Vladimir S, Antoniou, Antonis C, Smith, Shantel, Lee, Andrew, Hopper, John L, MacInnis, Robert J, Turnbull, Clare, Ramus, Susan J, Gayther, Simon A, Pharoah, Paul D P, Menon, Usha, Jacobs, Ian, Legood, Rosa

“…The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We…”
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Proliferation markers and survival in early breast cancer: A systematic review and meta-analysis of 85 studies in 32,825 patients by Stuart-Harris, R, Caldas, C, Pinder, S.E, Pharoah, P

“…Abstract We have performed a systematic review and meta-analysis of proliferation markers (Ki-67, mitotic index (MI), proliferating cell nuclear antigen (PCNA)…”
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Breast cancer risk factors and their effects on survival: a Mendelian randomisation study by Escala-Garcia, Maria, Morra, Anna, Canisius, Sander, Chang-Claude, Jenny, Kar, Siddhartha, Zheng, Wei, Bojesen, Stig E, Easton, Doug, Pharoah, Paul D P, Schmidt, Marjanka K

“…Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has…”
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p53 polymorphisms: cancer implications by Hollstein, Monica, Whibley, Catherine, Pharoah, Paul D. P

“…Key Points TP53 , which encodes p53, is a tumour suppressor gene that is frequently mutated in sporadic cancers. The mutations are usually single base…”
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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype by Barnett, Gillian C, West, Catherine M. L, Dunning, Alison M, Elliott, Rebecca M, Coles, Charlotte E, Pharoah, Paul D. P, Burnet, Neil G

“…Variation in sensitivity to radiation is an inherited genetic trait. This Perspective explores the possibility of genome-wide association studies to…”
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Predicting the likelihood of carrying a BRCA1 or BRCA2 mutation: validation of BOADICEA, BRCAPRO, IBIS, Myriad and the Manchester scoring system using data from UK genetics clinics by Antoniou, A C, Hardy, R, Walker, L, Evans, D G, Shenton, A, Eeles, R, Shanley, S, Pichert, G, Izatt, L, Rose, S, Douglas, F, Eccles, D, Morrison, P J, Scott, J, Zimmern, R L, Easton, D F, Pharoah, P D P

“…Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 has important implications for the clinical management of people found…”
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A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants by Gusev, Alexander, Lawrenson, Kate, Lin, Xianzhi, Lyra, Paulo C., Kar, Siddhartha, Vavra, Kevin C., Segato, Felipe, Fonseca, Marcos A. S., Lee, Janet M., Pejovic, Tanya, Liu, Gang, Karlan, Beth Y., Freedman, Matthew L., Noushmehr, Houtan, Monteiro, Alvaro N., Pharoah, Paul D. P., Pasaniuc, Bogdan, Gayther, Simon A.

“…We sought to identify susceptibility genes for high-grade serous ovarian cancer (HGSOC) by performing a transcriptome-wide association study of gene expression…”
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Validation of the online prediction tool PREDICT v. 2.0 in the Dutch breast cancer population by van Maaren, M.C., van Steenbeek, C.D., Pharoah, P.D.P., Witteveen, A., Sonke, G.S., Strobbe, L.J.A., Poortmans, P.M.P., Siesling, S.

“…PREDICT version 2.0 is increasingly used to estimate prognosis in breast cancer. This study aimed to validate this tool in specific prognostic subgroups in the…”
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