Search Results - "Pharmaceutical Sciences"

Addressing the Cold Reality of mRNA Vaccine Stability by Crommelin, Daan J A, Anchordoquy, Thomas J, Volkin, David B, Jiskoot, Wim, Mastrobattista, Enrico

“…As mRNA vaccines became the frontrunners in late-stage clinical trials to fight the COVID-19 pandemic, challenges surrounding their formulation and stability…”
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Physicochemical Stability of Monoclonal Antibodies: A Review by Le Basle, Yoann, Chennell, Philip, Tokhadze, Nicolas, Astier, Alain, Sautou, Valérie

“…Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature. In this work, we review the different mechanisms that can be…”
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Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs by Baghel, Shrawan, Cathcart, Helen, O'Reilly, Niall J

“…Poor water solubility of many drugs has emerged as one of the major challenges in the pharmaceutical world. Polymer-based amorphous solid dispersions have been…”
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Physiologically Based Pharmacokinetic Modeling in Regulatory Science: An Update From the U.S. Food and Drug Administration's Office of Clinical Pharmacology by Grimstein, Manuela, Yang, Yuching, Zhang, Xinyuan, Grillo, Joseph, Huang, Shiew-Mei, Zineh, Issam, Wang, Yaning

“…This commentary provides an update on the status of physiologically based pharmacokinetic modeling and simulation at the U.S. Food and Drug Administration's…”
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PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs by Turecek, Peter L, Bossard, Mary J, Schoetens, Freddy, Ivens, Inge A

“…Modification of biopharmaceutical molecules by covalent conjugation of polyethylene glycol (PEG) molecules is known to enhance pharmacologic and pharmaceutical…”
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Considerations for the Design of Antibody-Based Therapeutics by Goulet, Dennis R, Atkins, William M

“…Antibody-based proteins have become an important class of biologic therapeutics, due in large part to the stability, specificity, and adaptability of the…”
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Immunogenicity of Therapeutic Protein Aggregates by Moussa, Ehab M, Panchal, Jainik P, Moorthy, Balakrishnan S, Blum, Janice S, Joubert, Marisa K, Narhi, Linda O, Topp, Elizabeth M

“…Therapeutic proteins have a propensity for aggregation during manufacturing, shipping, and storage. The presence of aggregates in protein drug products can…”
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Advanced Therapeutic Dressings for Effective Wound Healing--A Review by Boateng, Joshua, Catanzano, Ovidio

“…Advanced therapeutic dressings that take active part in wound healing to achieve rapid and complete healing of chronic wounds is of current research interest…”
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Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System by Koziolek, Mirko, Grimm, Michael, Becker, Dieter, Iordanov, Ventzeslav, Zou, Hans, Shimizu, Jeff, Wanke, Christoph, Garbacz, Grzegorz, Weitschies, Werner

“…Gastrointestinal (GI) pH and temperature profiles under fasted-state conditions were investigated in two studies with each 10 healthy human subjects using the…”
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The Storage and In-Use Stability of mRNA Vaccines and Therapeutics: Not A Cold Case by Oude Blenke, Erik, Örnskov, Eivor, Schöneich, Christian, Nilsson, Gunilla A, Volkin, David B, Mastrobattista, Enrico, Almarsson, Örn, Crommelin, Daan J A

“…The remarkable impact of mRNA vaccines on mitigating disease and improving public health has been amply demonstrated during the COVID-19 pandemic. Many new…”
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Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages by Ghasemiyeh, Parisa, Mohammadi-Samani, Soliman

“…During the recent years, more attentions have been focused on lipid base drug delivery system to overcome some limitations of conventional formulations. Among…”
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Sodium Alginate as a Pharmaceutical Excipient: Novel Applications of a Well-known Polymer by Jadach, Barbara, Świetlik, Weronika, Froelich, Anna

“…Alginates are naturally occurring polymers revealing low toxicity, good biocompatibility and biodegradability, excellent gelling and thickening properties, as…”
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Oxidation and Deamidation of Monoclonal Antibody Products: Potential Impact on Stability, Biological Activity, and Efficacy by Gupta, Surbhi, Jiskoot, Wim, Schöneich, Christian, Rathore, Anurag S

“…The role in human health of therapeutic proteins in general, and monoclonal antibodies (mAbs) in particular, has been significant and is continuously evolving…”
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Review of Disintegrants and the Disintegration Phenomena by Desai, Parind Mahendrakumar, Liew, Celine Valeria, Heng, Paul Wan Sia

“…Disintegrant is one of the most important components in a typical tablet dosage form. It is responsible for ensuring the break-up of the tablet matrix upon…”
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The Future of Pharmaceutical Manufacturing Sciences by Rantanen, Jukka, Khinast, Johannes

“…The entire pharmaceutical sector is in an urgent need of both innovative technological solutions and fundamental scientific work, enabling the production of…”
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Molecular docking and dynamics simulations reveal the potential of anti-HCV drugs to inhibit COVID-19 main protease by Al-Karmalawy, Ahmed Ali, Alnajjar, Radwan, Dahab, Mohammed, Metwaly, Ahmed, Eissa, Ibrahim

“…Background: Drug repurposing is the fastest effective method to provide treatment for coronavirus disease (COVID-19). Drugs that targeting a closely related…”
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Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome by Pulingam, Thiruchelvi, Parumasivam, Thaigarajan, Gazzali, Amirah Mohd, Sulaiman, Azlinah Mohd, Chee, Jiun Yee, Lakshmanan, Manoj, Chin, Chai Fung, Sudesh, Kumar

“…Antibiotic resistance is a major health concern globally and has been estimated to cause 10 million deaths worldwide by year 2050 if the current trend of…”
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The Importance of Understanding the Freezing Step and Its Impact on Freeze-Drying Process Performance by Assegehegn, Getachew, Brito-de la Fuente, Edmundo, Franco, José M, Gallegos, Críspulo

“…The freeze-drying process is a combination of 2 equally important processes, freezing, and drying. In the past, the effort was mainly focused on optimizing the…”
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Three-Dimensional Printed PCL-Based Implantable Prototypes of Medical Devices for Controlled Drug Delivery by Holländer, Jenny, Genina, Natalja, Jukarainen, Harri, Khajeheian, Mohammad, Rosling, Ari, Mäkilä, Ermei, Sandler, Niklas

“…The goal of the present study was to fabricate drug-containing T-shaped prototypes of intrauterine system (IUS) with the drug incorporated within the entire…”
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Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity by Elnaggar, Yosra S R, Etman, Samar M, Abdelmonsif, Doaa A, Abdallah, Ossama Y

“…Piperine (PIP) is a phytopharmaceutical with reported neuroprotective potential in Alzheimer's disease (AD). Oral PIP delivery suffers from its hydrophobicity…”
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