Search Results - "Pharmaceutical Research"

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date by Bobo, Daniel, Robinson, Kye J., Islam, Jiaul, Thurecht, Kristofer J., Corrie, Simon R.

“…ABSTRACT In this review we provide an up to date snapshot of nanomedicines either currently approved by the US FDA, or in the FDA clinical trials process. We…”
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3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges by Jamróz, Witold, Szafraniec, Joanna, Kurek, Mateusz, Jachowicz, Renata

“…Growing demand for customized pharmaceutics and medical devices makes the impact of additive manufacturing increased rapidly in recent years. The 3D printing…”
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Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies? by Al Shoyaib, Abdullah, Archie, Sabrina Rahman, Karamyan, Vardan T.

“…Intraperitoneal (IP) route of drug administration in laboratory animals is a common practice in many in vivo studies of disease models. While this route is an…”
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Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio by Yang, Tianzhi, Martin, Paige, Fogarty, Brittany, Brown, Alison, Schurman, Kayla, Phipps, Roger, Yin, Viravuth P., Lockman, Paul, Bai, Shuhua

“…Purpose The blood–brain barrier (BBB) essentially restricts therapeutic drugs from entering into the brain. This study tests the hypothesis that brain…”
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Emergence of 3D Printed Dosage Forms: Opportunities and Challenges by Alhnan, Mohamed A., Okwuosa, Tochukwu C., Sadia, Muzna, Wan, Ka-Wai, Ahmed, Waqar, Arafat, Basel

“…The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare…”
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A Review of Disintegration Mechanisms and Measurement Techniques by Markl, Daniel, Zeitler, J. Axel

“…ABSTRACT Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to administer active pharmaceutical ingredients (APIs) to the…”
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Ethosomes as Nanocarriers for the Development of Skin Delivery Formulations by Paiva-Santos, Ana Cláudia, Silva, Ana Luísa, Guerra, Catarina, Peixoto, Diana, Pereira-Silva, Miguel, Zeinali, Mahdi, Mascarenhas-Melo, Filipa, Castro, Ricardo, Veiga, Francisco

“…The use of nanotechnology has been extensively explored for developing efficient drug delivery systems towards topical and transdermal applications. Ethosomes…”
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An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for Lipid-based Drug Delivery Systems by Vithani, Kapilkumar, Goyanes, Alvaro, Jannin, Vincent, Basit, Abdul W., Gaisford, Simon, Boyd, Ben J.

“…Purpose Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the…”
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Metformin – a Future Therapy for Neurodegenerative Diseases: Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla by Markowicz-Piasecka, Magdalena, Sikora, Joanna, Szydłowska, Aleksandra, Skupień, Agata, Mikiciuk-Olasik, Elżbieta, Huttunen, Kristiina M.

“…Type 2 diabetes mellitus (T2DM) is a complex, chronic and progressive metabolic disease, which is characterized by relative insulin deficiency, insulin…”
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Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin by Jeliński, Tomasz, Przybyłek, Maciej, Cysewski, Piotr

“…Purpose Study on curcumin dissolved in natural deep eutectic solvents (NADES) was aimed at exploiting their beneficial properties as drug carriers. Methods The…”
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Current ADC Linker Chemistry by Jain, Nareshkumar, Smith, Sean W., Ghone, Sanjeevani, Tomczuk, Bruce

“…The list of ADCs in the clinic continues to grow, bolstered by the success of first two marketed ADCs: ADCETRIS® and Kadcyla®. Currently, there are 40 ADCs in…”
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Pharmaceutical Development of AAV-Based Gene Therapy Products for the Eye by Rodrigues, Gerard A., Shalaev, Evgenyi, Karami, Thomas K., Cunningham, James, Slater, Nigel K. H., Rivers, Hongwen M.

“…A resurgence of interest and investment in the field of gene therapy, driven in large part by advances in viral vector technology, has recently culminated in…”
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Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery by Sun, Da, Lu, Zheng-Rong

“…Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and become major health issues, but the treatment development remains…”
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A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets by Okwuosa, Tochukwu C., Stefaniak, Dominika, Arafat, Basel, Isreb, Abdullah, Wan, Ka-Wai, Alhnan, Mohamed A.

“…Purpose The fabrication of ready-to-use immediate release tablets via 3D printing provides a powerful tool to on-demand individualization of dosage form. This…”
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Metformin - a Future Therapy for Neurodegenerative Diseases by Markowicz-Piasecka, Magdalena, Sikora, Joanna, Szydlowska, Aleksandra, Skupien, Agata, Mikiciuk-Olasik, Elzbieta, Huttunen, Kristiina M

“…Type 2 diabetes mellitus (T2DM) is a complex, chronic and progressive metabolic disease, which is characterized by relative insulin deficiency, insulin…”
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Effects of Particle Size and Surface Modification on Cellular Uptake and Biodistribution of Polymeric Nanoparticles for Drug Delivery by Kulkarni, Sneha A., Feng, Si-Shen

“…ABSTRACT Purpose To investigate the effects of the particle size and surface coating on the cellular uptake of the polymeric nanoparticles for drug delivery…”
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Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size by Di, Jiaxing, Du, Zhili, Wu, Kangzeng, Jin, Shanshan, Wang, Xun, Li, Tonglei, Xu, Yuhong

“…Purpose Lipid nanoparticles (LNPs) are widely utilized as means to deliver mRNA molecules. However, metric connections between biodistribution and…”
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L-Type amino acid transporter 1 as a target for drug delivery by Puris, Elena, Gynther, Mikko, Auriola, Seppo, Huttunen, Kristiina M.

“…Our growing understanding of membrane transporters and their substrate specificity has opened a new avenue in the field of targeted drug delivery. The L-type…”
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Two-Photon Polymerisation 3D Printing of Microneedle Array Templates with Versatile Designs: Application in the Development of Polymeric Drug Delivery Systems by Cordeiro, Ana Sara, Tekko, Ismaiel A., Jomaa, Mohamed H., Vora, Lalitkumar, McAlister, Emma, Volpe-Zanutto, Fabiana, Nethery, Matthew, Baine, Paul T., Mitchell, Neil, McNeill, David W., Donnelly, Ryan F.

“…Purpose To apply a simple and flexible manufacturing technique, two-photon polymerisation (2PP), to the fabrication of microneedle (MN) array templates with…”
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3D Printed “Starmix” Drug Loaded Dosage Forms for Paediatric Applications by Scoutaris, Nicolaos, Ross, Steven A., Douroumis, Dennis

“…Purpose Three- dimensional (3D) printing has received significant attention as a manufacturing process for pharmaceutical dosage forms. In this study, we used…”
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