Search Results - "Pharmaceutical Bulletin"

The Latest Research and Development into the Antibody–Drug Conjugate, [fam-] Trastuzumab Deruxtecan (DS-8201a), for HER2 Cancer Therapy by Nakada, Takashi, Sugihara, Kiyoshi, Jikoh, Takahiro, Abe, Yuki, Agatsuma, Toshinori

“…A major limitation of traditional chemotherapy for cancer is dose-limiting toxicity, caused by the exposure of non-tumor cells to cytotoxic agents. Use of…”
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1,4-Naphthoquinones: Some Biological Properties and Application by Aminin, Dmitry, Polonik, Sergey

“…Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features…”
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Potential Anticancer Activity of Auranofin by Onodera, Takefumi, Momose, Isao, Kawada, Manabu

“…Gold compounds have a long history of use in medicine. Auranofin was developed more than 30 years ago as an oral therapy for rheumatoid arthritis. Now,…”
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Possibility of Exosome-Based Therapeutics and Challenges in Production of Exosomes Eligible for Therapeutic Application by Yamashita, Takuma, Takahashi, Yuki, Takakura, Yoshinobu

“…Exosomes are cell-derived vesicles with a diameter 30–120 nm. Exosomes contain endogenous proteins and nucleic acids; delivery of these molecules to…”
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Recent Advances in Drug–Antibody Ratio Determination of Antibody–Drug Conjugates by Matsuda, Yutaka, Mendelsohn, Brian A.

“…Antibody–drug conjugates (ADCs) are biopharmaceuticals produced by chemically linking small molecules (payloads) to antibodies that possess specific affinity…”
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Chitosan Nanoparticles: A Promising System in Novel Drug Delivery by Nagpal, Kalpana, Singh, Shailendra Kumar, Mishra, Dina Nath

“…The ability of nanoparticles to manipulate the molecules and their structures has revolutionized the conventional drug delivery system. The chitosan…”
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The Different Mechanisms of Cancer Drug Resistance: A Brief Review by Mansoori, Behzad, Mohammadi, Ali, Davudian, Sadaf, Shirjang, Solmaz, Baradaran, Behzad

“…[...]the proteolysis of actin protein, and nuclear lamin proteins occurs in the external pathway and ultimately leads to cell apoptosis.32 In the internal…”
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Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics by Jan, Rehmat, Chaudhry, Gul-e-Saba

“…Various physiological processes involve appropriate tissue developmental process and homeostasis - the pathogenesis of several diseases connected with…”
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AMPK-Mediated Regulation of Lipid Metabolism by Phosphorylation by Wang, Qi, Liu, Shudong, Zhai, Aihua, Zhang, Bai, Tian, Guizhen

“…AMP-activated protein kinase (AMPK) is a metabolic sensor in mammals that is activated when ATP levels in the cell decrease. AMPK is a heterotrimeric protein…”
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Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC by Tanaka, Takashi, Nakashima, Tatsuya, Ueda, Toshihisa, Tomii, Kenji, Kouno, Isao

“…One-pot reactions of aldoses with L-cysteine methyl ester and o-tolyl isothiocyanate yielded methyl…”
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Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives by Kassem, Asmaa F., Nassar, Ibrahim F., Abdel-Aal, Mohammed T., Awad, Hanem M., El-Sayed, Wael A.

“…New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems were synthesized by reaction of the corresponding hydrazide with different…”
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Antibody–Drug Conjugate Payloads; Study of Auristatin Derivatives by Akaiwa, Michinori, Dugal-Tessier, Julien, Mendelsohn, Brian A.

“…Auristatins are important payloads used in antibody drug conjugates (ADCs), and the most well-known compound family member, monomethyl auristatin (MMAE), is…”
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Development of Chiral Thiourea Catalysts and Its Application to Asymmetric Catalytic Reactions by Takemoto, Yoshiji

“…We have developed several multifunctional thiourea catalysts bearing a tertiary amine or an 1,2-amino alcohol in expectation of their synchronous activation of…”
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Structure and Function of Δ9-Fatty Acid Desaturase by Nagao, Kohjiro, Murakami, Akira, Umeda, Masato

“…Δ9-Fatty acid desaturase (Δ9-desaturase) is a rate-limiting enzyme of unsaturated fatty acid biosynthesis in animal cells and specifically introduces a…”
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Current Understanding of Direct Translocation of Arginine-Rich Cell-Penetrating Peptides and Its Internalization Mechanisms by Takeuchi, Toshihide, Futaki, Shiroh

“…Arginine-rich cell-penetrating peptides (CPPs) including Tat, Penetratin and oligoarginine peptides are a series of short peptides that can be efficiently…”
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Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting by Garg, Unnati, Chauhan, Swati, Nagaich, Upendra, Jain, Neha

“…Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achieve…”
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A Review of Biologically Active Natural Products from a Desert Plant Cistanche tubulosa by Morikawa, Toshio, Xie, Haihui, Pan, Yingni, Ninomiya, Kiyofumi, Yuan, Dan, Jia, Xiaoguang, Yoshikawa, Masayuki, Nakamura, Seikou, Matsuda, Hisashi, Muraoka, Osamu

“…An Orobanchaceae plant Cistanche tubulosa (SCHENK) WIGHT (Kanka-nikujuyou in Japanese), which is one of the authorized plant resources as Cistanches Herba in…”
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7-Azaindole: A Versatile Scaffold for Developing Kinase Inhibitors by Irie, Takayuki, Sawa, Masaaki

“…The majority of kinase inhibitors have been developed as ATP competitors to interact with a hinge region in ATP binding sites of kinases. 7-Azaindole has been…”
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Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery by Chauhan, Iti, Yasir, Mohd, Verma, Madhu, Singh, Alok Pratap

“…Nanostructured lipid carriers (NLCs) are novel pharmaceutical formulations which are composed of physiological and biocompatible lipids, surfactants and…”
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Effect of the Molecularly Imprinted Polymer Component Ratio on Analytical Performance by Pratama, Kelvin Fernando, Manik, Maretty Erwanta Roulina, Rahayu, Driyanti, Hasanah, Aliya Nur

“…Molecular imprinting technology is a new analytical method that is highly selective and specific for certain analytes in artificial receptor design. The…”
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