Search Results - "Phanstiel Iv, Otto"

Caenorhabditis elegans P₅B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference by Heinick, Alexander, Urban, Katja, Roth, Stefan, Spies, Danica, Nunes, Frank, Phanstiel, Otto IV, Liebau, Eva, Lüersen, Kai

“…Physiological polyamines are required in various biological processes. In the current study, we used norspermidine, a structural analog of the natural…”
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Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation by Arnoletti, Juan Pablo, Reza, Joseph, Rosales, Armando, Monreal, Alberto, Fanaian, Na'im, Whisner, Suzanne, Srivastava, Milan, Rivera-Otero, Julia, Yu, Gongxin, Phanstiel Iv, Otto, Altomare, Deborah A, Tran, Quang, Litherland, Sally A

“…The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma (PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of…”
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Anthracene-Polyamine Conjugates Inhibit In Vitro Proliferation of Intraerythrocytic Plasmodium falciparum Parasites by NIEMAND, Jandeli, BURGER, Pieter, VERLINDEN, Bianca K, READER, Janette, JOUBERT, Annie M, KAISER, Annette, LOUW, Abraham I, KIRK, Kiaran, PHANSTIEL, Otto, BIRKHOLTZ, Lyn-Marie

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors by Peters, Molly C, Minton, Allyson, Phanstiel Iv, Otto, Gilmour, Susan K

“…Mutant serine/threonine protein kinase B-Raf (BRAF) protein is expressed in over half of all melanoma tumors. Although BRAF inhibitors (BRAFi) elicit rapid…”
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Defining the Molecular Requirements for the Selective Delivery of Polyamine Conjugates into Cells Containing Active Polyamine Transporters by Wang, Chaojie, Delcros, Jean-Guy, Cannon, Laura, Konate, Fanta, Carias, Horacio, Biggerstaff, John, Gardner, Richard Andrew, Phanstiel

“…Several N-substituted polyamines containing various spacer units between nitrogen centers were synthesized as their respective HCl salts. The N1-substituents…”
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Polyamine Transport as a Target for Treatment of Pneumocystis Pneumonia by LIAO, Chung-Ping, PHANSTIEL, Otto, LASBURY, Mark E, CHEN ZHANG, SHOUJIN SHAO, DURANT, Pamela J, CHENG, Bi-Hua, LEE, Chao-Hung

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Molecular Requirements for Targeting the Polyamine Transport System. Synthesis and Biological Evaluation of Polyamine−Anthracene Conjugates by Wang, Chaojie, Delcros, Jean-Guy, Biggerstaff, John, Phanstiel

“…A series of nine N -(9-anthracenylmethyl)tetraamines (e.g., Ant-4,4,4-tetraamine) were synthesized and evaluated for cytotoxicity in L1210,…”
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Total Synthesis of Petrobactin and Its Homologues as Potential Growth Stimuli for Marinobacter hydrocarbonoclasticus, an Oil-Degrading Bacteria by GARDNER, Richard Andrew, KINKADE, Rebecca, WANG, Chaojie, PHANSTIEL

“…A modular synthesis was developed to access petrobactin, a catechol-containing siderophore isolated from Marinobacter hydrocarbonoclasticus. A range of…”
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Synthesis and Biological Evaluation of Dihydromotuporamine Derivatives in Cells Containing Active Polyamine Transporters by Kaur, Navneet, Delcros, Jean-Guy, Martin, Bénédicte, Phanstiel

“…Dihydromotuporamine C (4) and its 4,4-triamine analogue (5) were synthesized in good yield using ring-closing metathesis (RCM) methods. Comparison of their…”
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Comparative studies of anthraquinone- and anthracene-tetraamines as blockers of N-methyl-D-aspartate receptors by Jin, Lihua, Sugiyama, Hiromi, Takigawa, Miki, Katagiri, Daisuke, Tomitori, Hideyuki, Nishimura, Kazuhiro, Kaur, Navneet, Phanstiel, 4th, Otto, Kitajima, Mariko, Takayama, Hiromitsu, Okawara, Tadashi, Williams, Keith, Kashiwagi, Keiko, Igarashi, Kazuei

“…Anthraquinone spermine [N1-(anthraquinone-2-carbonyl)spermine; AQ343], anthraquinone homospermine [N1-(anthraquinone-2-carbonyl; AQ444], anthracene spermine…”
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Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents by Wang, Jianhong, Xie, Songqiang, Li, Yanjie, Guo, Yongjun, Ma, Yuanfang, Zhao, Jin, Phanstiel, Otto, Wang, Chaojie

“…A series of unsymmetrically substituted polyamine derivatives were prepared and their cytotoxicities in mouse leukemia L1210, melanoma B16, and HeLa cells were…”
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Synthesis and Biological Evaluation of New Citrate-Based Siderophores as Potential Probes for the Mechanism of Iron Uptake in Mycobacteria by Guo, Hongyan, Naser, Saleh A, Ghobrial, George, Phanstiel

“…Several iron chelators containing α,β-unsaturated hydroxamic acid motifs appended to a citric acid platform were synthesized. Mycobacterium paratuberculosis…”
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Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers by Massaro, Chelsea, Thomas, Jenna, Phanstiel Iv, Otto

“…Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer…”
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ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers by Madan, Meenu, Patel, Arjun, Skruber, Kristen, Geerts, Dirk, Altomare, Deborah A, Iv, Otto Phanstiel

“…The purpose of this paper was to better understand the role of polyamine transport in pancreatic cancers.This paper identifies potential biomarkers for…”
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Synthesis and Biological Evaluation of New Acinetoferrin Homologues for Use as Iron Transport Probes in Mycobacteria by Gardner, Richard A, Ghobrial, George, Naser, Saleh A, Phanstiel

“…Four new acinetoferrin homologues were synthesized using a modular synthetic approach. Two linear and two cyclic imide derivatives were generated and evaluated…”
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Chemoselective N-Acylation via Condensations of N-(Benzoyloxy)amines and α-Ketophosphonic Acids under Aqueous Conditions by Arora, Jasbir Singh, Kaur, Navneet, IV, Otto Phanstiel

“…A new amide-forming reaction with N-benzoyloxyamines and α-ketophosphonic acids was investigated. A mixed solvent of t-BuOH/water (1:1) at 40 °C provided the…”
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Pancreatic Ductal Adenocarcinoma (PDAC) circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation by Juan Pablo Arnoletti, Joseph Reza, Armando Rosales, Alberto Monreal, Na’im Fanaian, Suzanne Whisner, Milan Srivastava, Julia Rivera-Otero, Gongxin Yu, Otto Phanstiel IV, Deborah A. Altomare, Quang Tran, Sally A. Litherland

“…The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma (PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of…”
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Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells by Elmarsafawi, Aya G, Hesterberg, Rebecca S, Fernandez, Mario R, Yang, Chunying, Darville, Lancia Nf, Liu, Min, Koomen, John M, Phanstiel, 4th, Otto, Atkins, Reginald, Mullinax, John E, Pilon-Thomas, Shari A, Locke, Frederick L, Epling-Burnette, Pearlie K, Cleveland, John L

“…Glutaminolysis is a hallmark of the activation and metabolic reprogramming of T cells. Isotopic tracer analyses of antigen-activated effector CD8+ T cells…”
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Utilization of Fe³⁺-acinetoferrin analogs as an iron source by Mycobacterium tuberculosis by Rodriguez, G. Marcela, Gardner, Richard, Kaur, Navneet, Phanstiel, Otto IV

“…Mycobacterium tuberculosis, the causative agent of human tuberculosis, synthesizes and secretes siderophores in order to compete for iron (an essential…”
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Influence of Polyamine Architecture on the Transport and Topoisomerase II Inhibitory Properties of Polyamine DNA−Intercalator Conjugates by Wang, Lu, Price, Harry L, Juusola, Jane, Kline, Martin, Phanstiel

“…An efficient five-step synthetic method was developed to access a series of spermine derivatives containing appended acridine, anthracene, and…”
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