Search Results - "Phang, James M."

Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses by Phang, James M

“…It is increasingly clear that proline metabolism plays an important role in metabolic reprogramming, not only in cancer but also in related fields such as…”
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Proline Metabolism in Tumor Growth and Metastatic Progression by D'Aniello, Cristina, Patriarca, Eduardo J, Phang, James M, Minchiotti, Gabriella

“…Cancer cells show a formidable capacity to survive under stringent conditions, to elude mechanisms of control, such as apoptosis, and to resist therapy. Cancer…”
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The regulatory mechanisms of proline and hydroxyproline metabolism: Recent advances in perspective by Phang, James M

“…For diverse human tumors, growth and metastasis are dependent on proline synthesis, but the mechanisms underlying this association are not clear. Proline…”
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Proline Metabolism and Microenvironmental Stress by Phang, James M, Liu, Wei, Zabirnyk, Olga

“…Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of enzymes responding to metabolic stress and participating in metabolic…”
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Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC by Liu, Wei, Le, Anne, Hancock, Chad, Lane, Andrew N., Dang, Chi V., Fan, Teresa W.-M., Phang, James M.

“…In addition to glycolysis, the oncogenic transcription factor c-MYC (MYC) stimulates glutamine catabolism to fuel growth and proliferation of cancer cells…”
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Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides by Liu, Wei, Hancock, Chad N., Fischer, Joseph W., Harman, Meredith, Phang, James M.

“…The metabolism of the nonessential amino acid proline contributes to tumor metabolic reprogramming. Previously we showed that MYC increases proline…”
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Proline metabolism and cancer by Phang, James M, Liu, Wei

“…Proline plays a special role in cancer metabolism. Proline oxidase (POX), a.k.a. proline dehydrogenase (PRODH), is among a few genes induced rapidly and…”
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The metabolism of proline as microenvironmental stress substrate by Phang, James M, Pandhare, Jui, Liu, Yongmin

“…Proline, a unique proteogenic secondary amino acid, has its own metabolic system with special features. Recent findings defining the regulation of this system…”
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Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment by Liu, Wei, Phang, James M.

“…Proline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the pathway of proline catabolism, has been identified as a mitochondrial, metabolic tumor…”
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metabolism of proline, a stress substrate, modulates carcinogenic pathways by Phang, James M, Donald, Steven P, Pandhare, Jui, Liu, Yongmin

“…The resurgence of interest in tumor metabolism has led investigators to emphasize the metabolism of proline as a “stress substrate” and to suggest this pathway…”
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Proline Oxidase Promotes Tumor Cell Survival in Hypoxic Tumor Microenvironments by WEI LIU, GLUNDE, Kristine, BHUJWALLA, Zaver M, RAMAN, Venu, SHARMA, Anit, PHANG, James M

“…Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species (ROS) to induce…”
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Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate by Hancock, Chad N., Liu, Wei, Alvord, W. Gregory, Phang, James M.

“…Proline dehydrogenase/oxidase (PRODH/POX) is a mitochondrial protein critical to multiple stress pathways. Because of the roles of PRODH/POX in signaling, and…”
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Regulation and function of proline oxidase under nutrient stress by Pandhare, Jui, Donald, Steven P., Cooper, Sandra K., Phang, James M.

“…Under conditions of nutrient stress, cells switch to a survival mode catabolizing cellular and tissue constituents for energy. Proline metabolism is especially…”
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Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers by YONGMIN LIU, BORCHERT, Gregory L, DONALD, Steven P, DIWAN, Bhalchandra A, ANVER, Miriam, PHANG, James M

“…Tumor metabolism and bioenergetics have become important topics for cancer research and are promising targets for anticancer therapy. Although glucose serves…”
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Depletion of Intracellular Ascorbate by the Carcinogenic Metals Nickel and Cobalt Results in the Induction of Hypoxic Stress by Salnikow, Konstantin, Donald, Steven P., Bruick, Richard K., Zhitkovich, Anatoly, Phang, James M., Kasprzak, Kazimierz S.

“…Exposure of cells to carcinogenic compounds of nickel(II) and cobalt(II) causes activation of the HIF-1 transcription factor and up-regulates a battery of…”
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Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis by Phang, James M.

“…In the 35 years since the introduction of the “proline cycle”, its relevance to human tumors has been widely established. These connections are based on a…”
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Extracellular matrix and HIF‐1 signaling: The role of prolidase by Surazynski, Arkadiusz, Donald, Steven P., Cooper, Sandra K., Whiteside, Martin A., Salnikow, Konstantin, Liu, Yongmin, Phang, James M.

“…Hypoxia‐inducible factor‐1 (HIF‐1) plays an important role in stress‐responsive gene expression. Although primarily sensitive to hypoxia, HIF‐1 signaling can…”
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Proline metabolism and cancer: emerging links to glutamine and collagen by Phang, James M, Liu, Wei, Hancock, Chad N, Fischer, Joseph W

“…PURPOSE OF REVIEWProline metabolism impacts a number of regulatory targets in both animals and plants and is especially important in cancer. Glutamine, a…”
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MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells by Liu, Yongmin, Borchert, Gregory L., Donald, Steven P., Surazynski, Arkadiusz, Hu, Chien-An, Weydert, Christine J., Oberley, Larry W., Phang, James M.

“…Proline oxidase (POX), localized on inner mitochondrial membranes, is encoded by a p53-induced gene and metabolically participates in p53-induced apoptosis…”
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A Novel Function for Hydroxyproline Oxidase in Apoptosis through Generation of Reactive Oxygen Species by Cooper, Sandra K., Pandhare, Jui, Donald, Steven P., Phang, James M.

“…Proline and hydroxyproline are metabolized by distinct pathways. Proline is important for protein synthesis, as a source of glutamate, arginine, and…”
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