Search Results - "Phan, U"
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Development of the anti-IL-10 mAb MK-1966 in combination with in situ vaccination of a TLR9 agonist SD-101 for cancer immunotherapy
Published in European journal of cancer (1990) (01-12-2016)“…MK-1966 is a humanized lgG1/kappa neutralizing monoclonal antibody (mAb) against interieukin-10 (IL-10). IL-10 is an anti-inflammatory cytokine that inhibits…”
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Defective Antigen Processing in GILT-Free Mice
Published in Science (American Association for the Advancement of Science) (09-11-2001)“…Processing of proteins for major histocompatibility complex (MHC) class II-restricted presentation to CD4-positive T lymphocytes occurs after they are…”
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Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile
Published in Journal of hepatology (01-03-1999)“…Background/Aims: The therapeutic benefit of ribavirin, a nucleoside analog, in the treatment of chronic HCV infection is seen even in the absence of any…”
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Utilization of Ultrafine Gas Bubbles to Investigate the Jones–Ray Effect of Diluted Salt Solutions
Published in Langmuir (14-12-2021)“…The cause of the Jones–Ray effect has been controversially debated for years. Ultrafine gas bubbles were employed to lessen the surface excess of the…”
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Utilizing polymer-conjugate albumin-based ultrafine gas bubbles in combination with ultra-high frequency radiations in drug transportation and delivery
Published in RSC advances (25-10-2021)“…The application of ultrafine bubbles as drug carriers in drug delivery is still in its developmental stage; it is important to obtain a thorough understanding…”
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A characterization of bioaerosols in biowaste pretreatment plants in relation to occupational health
Published in Waste management (Elmsford) (15-07-2021)“…•High microbial exposure in new biowaste recycling plants.•Several Risk Group 2 microorganisms identified.•High endotoxin, biofilm forming capacity, total…”
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Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action
Published in The Journal of biological chemistry (25-08-2000)“…We recently identified a gamma-interferon-inducible lysosomal thiol reductase (GILT), constitutively expressed in antigen-presenting cells, that catalyzes…”
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Enzymatic Reduction of Disulfide Bonds in Lysosomes: Characterization of a Gamma-Interferon-Inducible Lysosomal Thiol Reductase (GILT)
Published in Proceedings of the National Academy of Sciences - PNAS (18-01-2000)“…Proteins internalized into the endocytic pathway are usually degraded. Efficient proteolysis requires denaturation, induced by acidic conditions within…”
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Multiple species express thiol oxidoreductases related to GILT
Published in Immunogenetics (New York) (01-05-2001)“…Antigen-presenting cells activated CD4 super(+) T cells by presentation of peptide epitopes associated with major histocompatibility complex (MHC) class I…”
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Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes
Published in The Journal of experimental medicine (20-05-2002)“…Long-lasting tumor immunity requires functional mobilization of CD8+ and CD4+ T lymphocytes. CD4+ T cell activation is enhanced by presentation of shed tumor…”
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Evaluation of Methods for Sampling of Staphylococcus aureus and Other Staphylococcus Species from Indoor Surfaces
Published in Annals of work exposures and health (16-11-2020)“…Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing public and occupational health concern. As transmission of MRSA can occur via contact with…”
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Tandem High-dose Chemotherapy Followed by Autologous Transplantation in Patients with Locally Advanced or Metastatic Sarcoma
Published in Anticancer research (01-08-2009)“…Background: Patients with locally advanced or metastatic/recurrent soft tissue and Ewing's sarcoma (EWS) have few treatment options. The purpose of our phase…”
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Incidence and treatment of burns: A twenty-year experience from a single center in Germany
Published in Burns (01-02-2013)“…Abstract Objective To analyze trends in incidence and treatment of thermal injuries over the last two decades. Methods We retrospectively reviewed our local…”
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Oligonucleotide-mediated inhibition of CD28 expression induces human T cell hyporesponsiveness and manifests impaired contact hypersensitivity in mice
Published in The Journal of immunology (1950) (01-01-1997)“…Ligation of CD28 provides a costimulatory signal essential for Ag-mediated T cell activation via the TCR. Blocking CD28 ligation can inhibit cytokine…”
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A high affinity human antibody antagonist of P-selectin mediated rolling
Published in Biochemical and biophysical research communications (24-11-2006)“…We have characterized the IgG form of a previously isolated and engineered single-chain Fv (scFv), named RR2r3s4-1, that binds to human PSGL-1. This fully…”
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Role of the C-terminal propeptide in the activity and maturation of [gamma]-interferon-inducible lysosomal thiol reductase (GILT)
Published in Proceedings of the National Academy of Sciences - PNAS (17-09-2002)“…[gamma]-Interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in antigen-presenting cells. GILT facilitates unfolding of…”
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Identification of the low wall shear stress area in the middle and distal coronary artery: a dynamic angiography and deep learning analysis
Published in European heart journal (09-11-2023)“…Abstract Background Based on the principle and practice of fluid mechanic, when applying to the coronary circulation, at the location of turbulence (collision…”
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Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection
Published in The New England journal of medicine (22-12-2005)“…Influenza A (H5N1) virus with an amino acid substitution in neuraminidase that conferred high-level resistance to oseltamivir was isolated from two Vietnamese…”
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Fatal Avian Influenza A (H5N1) in a Child Presenting with Diarrhea Followed by Coma
Published in The New England journal of medicine (17-02-2005)“…In southern Vietnam, a four-year-old boy presented with severe diarrhea, followed by seizures, coma, and death. His nine-year-old sister had died from a…”
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