Search Results - "Phan, Ryan T."

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry by Dominguez-Sola, David, Victora, Gabriel D, Ying, Carol Y, Phan, Ryan T, Saito, Masumichi, Nussenzweig, Michel C, Dalla-Favera, Riccardo

“…The molecular control of germinal center selection is still being determined. Dalla-Favera and colleagues show that the cell-cycle regulator c-Myc is essential…”
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Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens by Liao, Wei, Jordaan, Gwen, Nham, Phillipp, Phan, Ryan T, Pelegrini, Matteo, Sharma, Sanjai

“…To determine differentially expressed and spliced RNA transcripts in chronic lymphocytic leukemia specimens a high throughput RNA-sequencing (HTS RNA-seq)…”
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Evolution of the immunoglobulin heavy chain class switch recombination mechanism by Chaudhuri, Jayanta, Basu, Uttiya, Zarrin, Ali, Yan, Catherine, Franco, Sonia, Perlot, Thomas, Vuong, Bao, Wang, Jing, Phan, Ryan T, Datta, Abhishek, Manis, John, Alt, Frederick W

“…To mount an optimum immune response, mature B lymphocytes can change the class of expressed antibody from IgM to IgG, IgA, or IgE through a…”
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Ovarian Cancer surgical consideration is markedly improved by the neural network powered-MIA3G multivariate index assay by Roy Choudhury, Manjusha, Pappas, Todd C, Twiggs, Leo B, Caoili, Emma, Fritsche, Herbert, Phan, Ryan T

“…Surgery remains the main treatment option for an adnexal mass suspicious of ovarian cancer. The malignancy rate is, however, only 10-15% in women undergoing…”
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Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice by Cheng, Hwei-Ling, Vuong, Bao Q, Basu, Uttiya, Franklin, Andrew, Schwer, Bjoern, Astarita, Jillian, Phan, Ryan T, Datta, Abhishek, Manis, John, Alt, Frederick W, Chaudhuri, Jayanta

“…Activation-induced cytidine deaminase (AID) is a single-stranded (ss) DNA-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch…”
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Validation of a deep neural network-based algorithm supporting clinical management of adnexal mass by Reilly, Gerard P, Dunton, Charles J, Bullock, Rowan G, Ure, Daniel R, Fritsche, Herbert, Ghosh, Srinka, Pappas, Todd C, Phan, Ryan T

“…Conservative management of adnexal mass is warranted when there is imaging-based and clinical evidence of benign characteristics. Malignancy risk is, however,…”
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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells by Dalla-Favera, Riccardo, Phan, Ryan T

“…The human proto-oncogene BCL6 encodes a BTB/POZ-zinc-finger transcriptional repressor that is necessary for germinal-centre formation and is implicated in the…”
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Neural network-derived multivariate index assay demonstrates effective clinical performance in longitudinal monitoring of ovarian cancer risk by Pappas, Todd C., Roy Choudhury, Manjusha, Chacko, Balu K., Twiggs, Leo B., Fritsche, Herbert, Elias, Kevin M., Phan, Ryan T.

“…We recently characterized the clinical performance of a multivariate index assay (MIA3G) to assess ovarian cancer risk for adnexal masses at initial…”
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Serum miRNA improves the accuracy of a multivariate index assay for triage of an adnexal mass by Webber, James W., Wollborn, Laura, Mishra, Sudhanshu, Vitonis, Allison F., Cramer, Daniel W., Phan, Ryan T., Pappas, Todd C., Stawiski, Konrad, Fendler, Wojciech, Chowdhury, Dipanjan, Elias, Kevin M.

“…To determine whether a multimodal assay combining serum microRNA with protein biomarkers and metadata improves triage assessment of an adnexal mass. Serum…”
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BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells by Dalla-Favera, Riccardo, Phan, Ryan T, Saito, Masumichi, Basso, Katia, Niu, Huifeng

“…The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center formation and has been linked to lymphomagenesis. BCL6…”
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Regulation of activation induced deaminase via phosphorylation by Basu, Uttiya, Chaudhuri, Jayanta, Phan, Ryan T, Datta, Abhishek, Alt, Frederick W

“…Immunoglobulin gene diversification by somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion is dependent upon activation-induced…”
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Validation of a gene expression signature to measure immune quiescence in kidney transplant recipients in the CLIA setting by Cheung, Rocky, Xu, Hua, Jin, Xia, Tian, Wenlan, Pinney, Kevin, Bu, Lihong, Stone, Steven, Woodward, Robert N, Agrawal, Nikhil, Dholakia, Shamik, Phan, Ryan T

“…Allograft rejection remains a major cause of graft failure in kidney transplantation. Here the authors report the validation of a non-invasive molecular…”
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Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells by Dalla-Favera, Riccardo, Phan, Ryan T, Saito, Masumichi, Kitagawa, Yukiko, Means, Anthony R

“…Antigen-specific B cells are selected in germinal centers, the structure in which these cells proliferate while accomplishing genome-remodeling processes such…”
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KRAS mutation status impacts diagnosis and treatment decision in a patient with two colon tumours: a case report by Li, Xiaodong, Pezeshkpour, G, Phan, Ryan T

“…KRAS mutation status predicts response to anti-EGFR therapy in colorectal cancer patients. Here we report an interesting case of discordant KRAS mutation…”
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BCL6 Interacts with Cullin-3 Ubiquitin Ligase Complex In B Cells by Phan, Ryan T, Nguyen, DanVy, Nham, Phillipp, Dalla-Favera, Riccardo

“…Abstract 3129 The proto-oncogene BCL6 encodes for a BTB/POZ-zinc finger transcriptional repressor which plays an essential role in germinal center (GC)…”
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c-MYC is required for germinal center selection and cyclic re-entry by Dominguez-Sola, David, Victora, Gabriel D., Ying, Carol Y., Phan, Ryan T., Saito, Masumichi, Nussenzweig, Michel C., Dalla-Favera, Riccardo

“…Upon antigenic challenge, B cells enter the dark-zone (DZ) of germinal-centers (GC) to proliferate and hypermutate their immunoglobulin genes. Mutants with…”
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A Germinal Center- Derived B Cell Lymphoma Model by Phan, Ryan T, Nguyen, Khang, Romero, Sonia, Nicolson, Alice, Nham, Phillipp, Nguyen, Dany V.

“…Abstract 2008 Most human B-cell lymphomas represent mature phenotypes of germinal center (GC) or post-GC origin and are frequently associated with chromosomal…”
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Pathologic Co-Expression and Physical Interaction of c-MYC and BCL6 in B-Cell Lymphomas by Saito, Masumichi, Phan, Ryan T., Morse, Herbert C., Pasqualucci, Laura, Dalla-Favera, Riccardo

“…Deregulated expression of the proto-oncogenes BCL6 and c-MYC caused by chromosomal translocation or somatic hypermutation is common in non-Hodgkin B cell…”
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The BCL6 Proto-Oncogene Suppresses p53 Expression in Germinal-Center B Cells by Phan, Ryan T., Niu, Huifeng, Saito, Masumichi, Basso, Katia, Cattoretti, Giorgio, Dalla-Favera, Riccardo

“…The proto-oncogene BCL6 encodes a BTB/POZ-zinc finger transcriptional repressor that is necessary for germinal center (GC) formation and is implicated in the…”
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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells by Phan, Ryan T, Dalla-Favera, Riccardo

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