Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions

Review on Databases and Bioinformatic Approaches on Pharmacogenomics of Adverse Drug Reactions

Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for...

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Bibliographic Details
Published in:Pharmacogenomics and personalized medicine Vol. 14; pp. 61 - 75
Main Authors: Tong, Hang, Phan, Nga V T, Nguyen, Thanh T, Nguyen, Dinh V, Vo, Nam S, Le, Ly
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2021
Taylor & Francis Ltd
Dove
Subjects:
Analysis
Cytochrome
Design
Disease
Drug dosages
Enzymes
Genes
Genetic diversity
Genetic factors
Genetic transformation
Genomes
Health aspects
Information management
Metabolism
Next-generation sequencing
Pharmacogenetics
Pharmacogenomics
Review
Sequence analysis
Vietnam
Japan
adverse drug reactions
pharmacogenomics
next generation sequencing
candidate gene approach
genome-wide association study
Online Access:Get full text
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Summary:Pharmacogenomics has been used effectively in studying adverse drug reactions by determining the person-specific genetic factors associated with individual response to a drug. Current approaches have revealed the significant importance of sequencing technologies and sequence analysis strategies for interpreting the contribution of genetic variation in developing adverse reactions. Advance in next generation sequencing and platform brings new opportunities in validating the genetic candidates in certain reactions, and could be used to develop the preemptive tests to predict the outcome of the variation in a personal response to a drug. With the highly accumulated available data recently, the in silico approach with data analysis and modeling plays as other important alternatives which significantly support the final decisions in the transformation from research to clinical applications such as diagnosis and treatments for various types of adverse responses.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1178-7066
1178-7066
DOI:10.2147/PGPM.S290781