Search Results - "Phan, Isabelle"

Calmodulin-like proteins localized to the conoid regulate motility and cell invasion by Toxoplasma gondii by Long, Shaojun, Brown, Kevin M, Drewry, Lisa L, Anthony, Bryan, Phan, Isabelle Q H, Sibley, L David

“…Toxoplasma gondii contains an expanded number of calmodulin (CaM)-like proteins whose functions are poorly understood. Using a combination of…”
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A divergent protein kinase A regulatory subunit essential for morphogenesis of the human pathogen Leishmania by Fischer Weinberger, Renana, Bachmaier, Sabine, Ober, Veronica, Githure, George B, Dandugudumula, Ramu, Phan, Isabelle Q, Almoznino, Michal, Polatoglou, Eleni, Tsigankov, Polina, Nitzan Koren, Roni, Myler, Peter J, Boshart, Michael, Zilberstein, Dan

“…Parasitic protozoa of the genus Leishmania cycle between the phagolysosome of mammalian macrophages, where they reside as rounded intracellular amastigotes,…”
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Infrastructure for the life sciences: design and implementation of the UniProt website by Jain, Eric, Bairoch, Amos, Duvaud, Severine, Phan, Isabelle, Redaschi, Nicole, Suzek, Baris E, Martin, Maria J, McGarvey, Peter, Gasteiger, Elisabeth

“…The UniProt consortium was formed in 2002 by groups from the Swiss Institute of Bioinformatics (SIB), the European Bioinformatics Institute (EBI) and the…”
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TriTrypDB: a functional genomic resource for the Trypanosomatidae by Aslett, Martin, Aurrecoechea, Cristina, Berriman, Matthew, Brestelli, John, Brunk, Brian P, Carrington, Mark, Depledge, Daniel P, Fischer, Steve, Gajria, Bindu, Gao, Xin, Gardner, Malcolm J, Gingle, Alan, Grant, Greg, Harb, Omar S, Heiges, Mark, Hertz-Fowler, Christiane, Houston, Robin, Innamorato, Frank, Iodice, John, Kissinger, Jessica C, Kraemer, Eileen, Li, Wei, Logan, Flora J, Miller, John A, Mitra, Siddhartha, Myler, Peter J, Nayak, Vishal, Pennington, Cary, Phan, Isabelle, Pinney, Deborah F, Ramasamy, Gowthaman, Rogers, Matthew B, Roos, David S, Ross, Chris, Sivam, Dhileep, Smith, Deborah F, Srinivasamoorthy, Ganesh, Stoeckert, Christian J. Jr, Subramanian, Sandhya, Thibodeau, Ryan, Tivey, Adrian, Treatman, Charles, Velarde, Giles, Wang, Haiming

“…TriTrypDB (http://tritrypdb.org) is an integrated database providing access to genome-scale datasets for kinetoplastid parasites, and supporting a variety of…”
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Enolase inhibitors as therapeutic leads for Naegleria fowleri infection by Milanes, Jillian E, Yan, Victoria C, Pham, Cong-Dat, Muller, Florian, Kwain, Samuel, Rees, Kerrick C, Dominy, Brian N, Whitehead, Daniel C, Millward, Steven W, Bolejack, Madison, Shek, Roger, Tillery, Logan, Phan, Isabelle Q, Staker, Bart, Moseman, E Ashley, Zhang, Xiang, Ma, Xipeng, Jebet, Audriy, Yin, Xinmin, Morris, James C

“…Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic…”
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Combining functional and structural genomics to sample the essential Burkholderia structome by Baugh, Loren, Gallagher, Larry A, Patrapuvich, Rapatbhorn, Clifton, Matthew C, Gardberg, Anna S, Edwards, Thomas E, Armour, Brianna, Begley, Darren W, Dieterich, Shellie H, Dranow, David M, Abendroth, Jan, Fairman, James W, Fox, 3rd, David, Staker, Bart L, Phan, Isabelle, Gillespie, Angela, Choi, Ryan, Nakazawa-Hewitt, Steve, Nguyen, Mary Trang, Napuli, Alberto, Barrett, Lynn, Buchko, Garry W, Stacy, Robin, Myler, Peter J, Stewart, Lance J, Manoil, Colin, Van Voorhis, Wesley C

“…The genus Burkholderia includes pathogenic gram-negative bacteria that cause melioidosis, glanders, and pulmonary infections of patients with cancer and cystic…”
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In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 by Phan, Isabelle Q., Subramanian, Sandhya, Kim, David, Murphy, Michael, Pettie, Deleah, Carter, Lauren, Anishchenko, Ivan, Barrett, Lynn K., Craig, Justin, Tillery, Logan, Shek, Roger, Harrington, Whitney E., Koelle, David M., Wald, Anna, Veesler, David, King, Neil, Boonyaratanakornkit, Jim, Isoherranen, Nina, Greninger, Alexander L., Jerome, Keith R., Chu, Helen, Staker, Bart, Stewart, Lance, Myler, Peter J., Van Voorhis, Wesley C.

“…Rapid generation of diagnostics is paramount to understand epidemiology and to control the spread of emerging infectious diseases such as COVID-19…”
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The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design by Phan, Isabelle Q., Rice, Christopher A., Craig, Justin, Noorai, Rooksana E., McDonald, Jacquelyn R., Subramanian, Sandhya, Tillery, Logan, Barrett, Lynn K., Shankar, Vijay, Morris, James C., Van Voorhis, Wesley C., Kyle, Dennis E., Myler, Peter J.

“…Balamuthia mandrillaris , a pathogenic free-living amoeba, causes cutaneous skin lesions as well as granulomatous amoebic encephalitis, a ‘brain-eating’…”
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The Rickettsia type IV secretion system: unrealized complexity mired by gene family expansion by Gillespie, Joseph J., Phan, Isabelle Q. H., Driscoll, Timothy P., Guillotte, Mark L., Lehman, Stephanie S., Rennoll-Bankert, Kristen E., Subramanian, Sandhya, Beier-Sexton, Magda, Myler, Peter J., Rahman, M. Sayeedur, Azad, Abdu F.

“…Many prokaryotes utilize type IV secretion systems (T4SSs) to translocate substrates (e.g. nucleoprotein, DNA, protein) across the cell envelope, and/or to…”
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The domain architecture of the protozoan protein J-DNA–binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity by Adamopoulos, Athanassios, Heidebrecht, Tatjana, Roosendaal, Jeroen, Touw, Wouter G., Phan, Isabelle Q., Beijnen, Jos, Perrakis, Anastassis

“…J-DNA–binding protein 1 (JBP1) contributes to the biosynthesis and maintenance of base J (β-d-glucosyl-hydroxymethyluracil), an epigenetic modification of…”
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Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase by Milanes, Jillian E, Suryadi, Jimmy, Abendroth, Jan, Van Voorhis, Wesley C, Barrett, Kayleigh F, Dranow, David M, Phan, Isabelle Q, Patrick, Stephen L, Rozema, Soren D, Khalifa, Muhammad M, Golden, Jennifer E, Morris, James C

“…Infection with the free-living amoeba leads to life-threatening primary amoebic meningoencephalitis. Efficacious treatment options for these infections are…”
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Multiplexed Functional Assessment of Genetic Variants in CARD11 by Meitlis, Iana, Allenspach, Eric J., Bauman, Bradly M., Phan, Isabelle Q., Dabbah, Gina, Schmitt, Erica G., Camp, Nathan D., Torgerson, Troy R., Nickerson, Deborah A., Bamshad, Michael J., Hagin, David, Luthers, Christopher R., Stinson, Jeffrey R., Gray, Jessica, Lundgren, Ingrid, Church, Joseph A., Butte, Manish J., Jordan, Mike B., Aceves, Seema S., Schwartz, Daniella M., Milner, Joshua D., Schuval, Susan, Skoda-Smith, Suzanne, Cooper, Megan A., Starita, Lea M., Rawlings, David J., Snow, Andrew L., James, Richard G.

“…Genetic testing has increased the number of variants identified in disease genes, but the diagnostic utility is limited by lack of understanding variant…”
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Structure of acid deoxyribonuclease by Varela-Ramirez, Armando, Abendroth, Jan, Mejia, Adrian A, Phan, Isabelle Q, Lorimer, Donald D, Edwards, Thomas E, Aguilera, Renato J

“…Deoxyribonuclease II (DNase II) is also known as acid deoxyribonuclease because it has optimal activity at the low pH environment of lysosomes where it is…”
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Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty by Carnes, Jason, Anupama, Atashi, Balmer, Oliver, Jackson, Andrew, Lewis, Michael, Brown, Rob, Cestari, Igor, Desquesnes, Marc, Gendrin, Claire, Hertz-Fowler, Christiane, Imamura, Hideo, Ivens, Alasdair, Kořený, Luděk, Lai, De-Hua, MacLeod, Annette, McDermott, Suzanne M, Merritt, Chris, Monnerat, Severine, Moon, Wonjong, Myler, Peter, Phan, Isabelle, Ramasamy, Gowthaman, Sivam, Dhileep, Lun, Zhao-Rong, Lukeš, Julius, Stuart, Ken, Schnaufer, Achim

“…Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence from the tsetse fly as obligatory vector, and independence…”
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Characterization of Glucokinases from Pathogenic Free-Living Amoebae by Milanes, Jillian E, Suryadi, Jimmy, Monaghan, Neil P, Harding, Elijah M, Morris, Corbin S, Rozema, Soren D, Khalifa, Muhammad M, Golden, Jennifer E, Phan, Isabelle Q, Zigweid, Rachael, Abendroth, Jan, Rice, Christopher A, McCord, Hayden T, Wilson, Stevin, Fenwick, Michael K, Morris, James C

“…Infection with pathogenic free-living amoebae, including Naegleria fowleri, spp., and Balamuthia mandrillaris, can lead to life-threatening illnesses,…”
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Toward a structome of Acinetobacter baumannii drug targets by Tillery, Logan M., Barrett, Kayleigh F., Dranow, David M., Craig, Justin, Shek, Roger, Chun, Ian, Barrett, Lynn K., Phan, Isabelle Q., Subramanian, Sandhya, Abendroth, Jan, Lorimer, Donald D., Edwards, Thomas E., Van Voorhis, Wesley C.

“…Acinetobacter baumannii is well known for causing hospital‐associated infections due in part to its intrinsic antibiotic resistance as well as its ability to…”
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Biological and structural characterization of a host-adapting amino acid in influenza virus by Yamada, Shinya, Hatta, Masato, Staker, Bart L, Watanabe, Shinji, Imai, Masaki, Shinya, Kyoko, Sakai-Tagawa, Yuko, Ito, Mutsumi, Ozawa, Makoto, Watanabe, Tokiko, Sakabe, Saori, Li, Chengjun, Kim, Jin Hyun, Myler, Peter J, Phan, Isabelle, Raymond, Amy, Smith, Eric, Stacy, Robin, Nidom, Chairul A, Lank, Simon M, Wiseman, Roger W, Bimber, Benjamin N, O'Connor, David H, Neumann, Gabriele, Stewart, Lance J, Kawaoka, Yoshihiro

“…Two amino acids (lysine at position 627 or asparagine at position 701) in the polymerase subunit PB2 protein are considered critical for the adaptation of…”
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Structural diversity in the Mycobacteria DUF3349 superfamily by Buchko, Garry W., Abendroth, Jan, Robinson, John I., Phan, Isabelle Q., Myler, Peter J., Edwards, Thomas E.

“…A protein superfamily with a “Domain of Unknown Function,”, DUF3349 (PF11829), is present predominately in Mycobacterium and Rhodococcus bacterial species…”
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Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba by Tillery, Logan, Barrett, Kayleigh, Goldstein, Jenna, Lassner, Jared W, Osterhout, Bram, Tran, Nathan L, Xu, Lily, Young, Ryan M, Craig, Justin, Chun, Ian, Dranow, David M, Abendroth, Jan, Delker, Silvia L, Davies, Douglas R, Mayclin, Stephen J, Calhoun, Brandy, Bolejack, Madison J, Staker, Bart, Subramanian, Sandhya, Phan, Isabelle, Lorimer, Donald D, Myler, Peter J, Edwards, Thomas E, Kyle, Dennis E, Rice, Christopher A, Morris, James C, Leahy, James W, Manetsch, Roman, Barrett, Lynn K, Smith, Craig L, Van Voorhis, Wesley C

“…Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa,…”
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Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems by Gillespie, Joseph J, Phan, Isabelle Q H, Scheib, Holger, Subramanian, Sandhya, Edwards, Thomas E, Lehman, Stephanie S, Piitulainen, Hanna, Rahman, M Sayeedur, Rennoll-Bankert, Kristen E, Staker, Bart L, Taira, Suvi, Stacy, Robin, Myler, Peter J, Azad, Abdu F, Pulliainen, Arto T

“…Prokaryotes use type IV secretion systems (T4SSs) to translocate substrates (e.g., nucleoprotein, DNA, and protein) and/or elaborate surface structures (i.e.,…”
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