Search Results - "Phan, Anh Tuân"

Human telomeric G-quadruplex: structures of DNA and RNA sequences by Phan, Anh Tuân

“…Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure,…”
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Structure of Human Telomeric DNA in Crowded Solution by Heddi, Brahim, Phan, Anh Tuân

“…G-quadruplex structures formed by DNA at the human telomeres are attractive anticancer targets. Human telomeric sequences can adopt a diverse range of…”
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Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex by Heddi, Brahim, Cheong, Vee Vee, Martadinata, Herry, Phan, Anh Tuân

“…Four-stranded nucleic acid structures called G-quadruplexes have been associated with important cellular processes, which should require G-quadruplex–protein…”
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Major G‑Quadruplex Form of HIV‑1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop by Butovskaya, Elena, Heddi, Brahim, Bakalar, Blaž, Richter, Sara N, Phan, Anh Tuân

“…Nucleic acids can form noncanonical four-stranded structures called G-quadruplexes. G-quadruplex-forming sequences are found in several genomes including human…”
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Structural Basis of DNA Quadruplex-Duplex Junction Formation by Lim, Kah Wai, Phan, Anh Tuân

“…Coaxial and orthogonal orientations of the helices (left and right illustration, respectively) in a quadruplex–duplex junction were realized by incorporating a…”
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Solution Structures of a G‑Quadruplex Bound to Linear- and Cyclic-Dinucleotides by Winnerdy, Fernaldo Richtia, Das, Poulomi, Heddi, Brahim, Phan, Anh Tuân

“…Cyclic dinucleotides have emerged as important secondary messengers and cell signaling molecules that regulate several cell responses. A guanine-deficit…”
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Folding Kinetics of G‑Quadruplexes: Duplex Stem Loops Drive and Accelerate G‑Quadruplex Folding by Nguyen, Thi Quynh Ngoc, Lim, Kah Wai, Phan, Anh Tuân

“…The folding kinetics is an important parameter affecting the relevance of DNA and RNA G-quadruplex (G4) structures in biological processes. Previous studies of…”
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Monomer-Dimer Equilibrium for the 5′-5′ Stacking of Propeller-Type Parallel-Stranded G-Quadruplexes: NMR Structural Study by Do, Ngoc Quang, Phan, Anh Tuân

“…Guanine‐rich sequence motifs, which contain tracts of three consecutive guanines connected by single non‐guanine nucleotides, are abundant in the human genome…”
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Structure of Human Telomeric RNA (TERRA): Stacking of Two G‑Quadruplex Blocks in K+ Solution by Martadinata, Herry, Phan, Anh Tuân

“…Telomeric repeat-containing RNAs (TERRA) are transcription products of the telomeres. Human TERRA sequences containing UU­A­G­GG repeats can form…”
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Structural Basis for Parallel G‑Quadruplex Recognition by an Ankyrin Protein by Ngo, Khac Huy, Liew, Chong Wai, Heddi, Brahim, Phan, Anh Tuân

“…G-Quadruplex (G4) structures formed by guanine-rich DNA and RNA sequences are implicated in various biological processes. Understanding the mechanisms by which…”
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Solution Structure of an Intramolecular (3 + 1) Human Telomeric G‑Quadruplex Bound to a Telomestatin Derivative by Chung, Wan Jun, Heddi, Brahim, Tera, Masayuki, Iida, Keisuke, Nagasawa, Kazuo, Phan, Anh Tuân

“…Guanine-rich human telomeric DNA can adopt secondary structures known as G-quadruplexes, which can be targeted by small molecules to achieve anticancer…”
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Structure of a left-handed DNA G-quadruplex by Chung, Wan Jun, Heddi, Brahim, Schmitt, Emmanuelle, Lim, Kah Wai, Mechulam, Yves, Phan, Anh Tuân

“…Significance DNA can adopt diverse structural conformations including duplexes, triplexes, and quadruplexes. Four-stranded structures known as G-quadruplexes…”
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Intra-locked G-quadruplex structures formed by irregular DNA G-rich motifs by Maity, Arijit, Winnerdy, Fernaldo Richtia, Chang, Weili Denyse, Chen, Gang, Phan, Anh Tuân

“…Abstract G-rich DNA sequences with tracts of three or more continuous guanines (G≥3) are known to have high propensity to adopt stable G-quadruplex (G4)…”
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Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3 by Chung, Wan Jun, Heddi, Brahim, Hamon, Florian, Teulade-Fichou, Marie-Paule, Phan, Anh Tuân

“…Phen‐DC3 is a highly promising compound that specifically targets G‐quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to…”
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Structure of Propeller-Type Parallel-Stranded RNA G-Quadruplexes, Formed by Human Telomeric RNA Sequences in K+ Solution by Martadinata, Herry, Phan, Anh Tuân

“…Very recent studies showed that mammalian telomeres were transcribed into telomeric-repeat-containing RNAs and suggested that these RNA molecules were…”
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Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA‐Binding Components to a G‐Quadruplex and Its Proximal Duplex by Asamitsu, Sefan, Obata, Shunsuke, Phan, Anh Tuân, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi

“…A G‐quadruplex (quadruplex) is a nucleic acid secondary structure adopted by guanine‐rich sequences and is considered to be relevant to various pharmacological…”
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High-resolution AFM structure of DNA G-wires in aqueous solution by Bose, Krishnashish, Lech, Christopher J., Heddi, Brahim, Phan, Anh Tuân

“…We investigate the self-assembly of short pieces of the Tetrahymena telomeric DNA sequence d[G 4 T 2 G 4 ] in physiologically relevant aqueous solution using…”
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Duplexes Formed by G4C2 Repeats Contain Alternate Slow- and Fast-Flipping G·G Base Pairs by Maity, Arijit, Winnerdy, Fernaldo Richtia, Chen, Gang, Phan, Anh Tuân

“…Aberrant expansion of the hexanucleotide GGGGCC (or G4C2) repeat in the human C9ORF72 gene is the most common genetic factor found behind amyotrophic lateral…”
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Formation of G‑Quadruplexes in Poly‑G Sequences: Structure of a Propeller-Type Parallel-Stranded G‑Quadruplex Formed by a G15 Stretch by Sengar, Anjali, Heddi, Brahim, Phan, Anh Tuân

“…Poly-G sequences are found in different genomes including human and have the potential to form higher-order structures with various applications. Previously,…”
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Formation of a Stacked Dimeric G‑Quadruplex Containing Bulges by the 5′-Terminal Region of Human Telomerase RNA (hTERC) by Martadinata, Herry, Phan, Anh Tuân

“…We investigate the structure formed by the first 18-nt of the 5′-terminal region of the human telomerase RNA (hTERC or hTR) using gel electrophoresis and UV,…”
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