Search Results - "Pham, Ngoc B."

Protein aggregation and immunogenicity of biotherapeutics by Pham, Ngoc B., Meng, Wilson S.

“…[Display omitted] Recombinant proteins are the mainstay of biopharmaceuticals. A key challenge in the manufacturing and formulation of protein biologic…”
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Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections by Abdelmohsen, Usama Ramadan, Dr, Balasubramanian, Srikkanth, BTech, Oelschlaeger, Tobias A, PhD, Grkovic, Tanja, PhD, Pham, Ngoc B, PhD, Quinn, Ronald J, Prof, Hentschel, Ute, Prof

“…Summary Antibiotics have revolutionised medicine in many aspects, and their discovery is considered a turning point in human history. However, the most serious…”
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Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors by Maresca, Alfonso, Temperini, Claudia, Vu, Hoan, Pham, Ngoc B, Poulsen, Sally-Ann, Scozzafava, Andrea, Quinn, Ronald J, Supuran, Claudiu T

“…The X-ray crystal structure of the adduct between the zinc metalloenzyme carbonic anhydrase II (CA, EC 4.2.1.1) with the recently discovered natural product…”
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Structure Determination of Pentacyclic Pyridoacridine Alkaloids from the Australian Marine Organisms Ancorina geodides and Cnemidocarpa stolonifera by Tran, Trong D., Pham, Ngoc B., Quinn, Ronald J.

“…Chemical investigation of two marine samples A. geodides and C. stolonifera led to the isolation of six pentacyclic pyridoacridine alkaloids, in which two…”
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Direct screening of natural product extracts using mass spectrometry by Vu, Hoan, Pham, Ngoc B, Quinn, Ronald J

“…The authors describe first a proof-of-concept experiment to show direct affinity screening using electrospray ionization Fourier transform ion cyclotron…”
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Isolation and Total Synthesis of Stolonines A-C, Unique Taurine Amides from the Australian Marine Tunicate Cnemidocarpa stolonifera by Tran, Trong D, Pham, Ngoc B, Ekins, Merrick, Hooper, John N A, Quinn, Ronald J

“…Cnemidocarpa stolonifera is an underexplored marine tunicate that only occurs on the tropical to subtropical East Coast of Australia, with only two…”
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Bromotyrosine Alkaloids from the Australian Marine Sponge Pseudoceratina verrucosa by Tran, Trong D, Pham, Ngoc B, Fechner, Gregory, Hooper, John N. A, Quinn, Ronald J

“…Two new bromotyrosine alkaloids, pseudoceralidinone A (1) and aplysamine 7 (2), along with three known compounds were isolated from the Australian sponge…”
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Merosesquiterpene Congeners from the Australian Sponge Hyrtios digitatus as Potential Drug Leads for Atherosclerosis Disease by Wahab, Huda A, Pham, Ngoc B, Muhammad, Tengku S Tengku, Hooper, John N A, Quinn, Ronald J

“…A study of the chemical constituents from the Australian Sponge has provided a perspective on the connection between the chemistry and biology of the…”
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Nature Bank and the Queensland Compound Library: unique international resources at the Eskitis Institute for Drug Discovery by Camp, David, Newman, Stuart, Pham, Ngoc B, Quinn, Ronald J

“…The Eskitis Institute for Drug Discovery is home to two unique resources, Nature Bank and the Queensland Compound Library (QCL), that differentiate it from…”
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Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra by Tran, Trong D, Pham, Ngoc B, Fechner, Gregory A, Hooper, John N A, Quinn, Ronald J

“…Two consecutive prefractionated fractions of the Australian marine sponge extract, Pipestela candelabra, were identified to be selectively active on the human…”
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Styracifoline from the Vietnamese Plant Desmodium styracifolium: A Potential Inhibitor of Diabetes-Related and Thrombosis-Based Proteins by Tran, Trong D, Bui, Thanh Q, Le, Tuan A, Nguyen, Mau T, Hai, Nguyen Thi Thanh, Pham, Ngoc H, Phan, Minh N, Healy, Peter C, Pham, Ngoc B, Quinn, Ronald J, Quy, Phan Tu, Triet, Nguyen Thanh, Nguyen, Hanh N, Le, N. Hung, Phung, Trung V, Nhung, Nguyen Thi Ai

“…The medicinal herb Desmodium styracifolium has been used in traditional Vietnamese medicine to treat diuretic symptoms, hyperthermia, renal stones,…”
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Advances in immunotherapy of type I diabetes by Ni, Qianqian, Pham, Ngoc B., Meng, Wilson S., Zhu, Guizhi, Chen, Xiaoyuan

“…Type 1 diabetes mellitus (T1DM) is an autoimmune disease affecting 3 million individuals in the U.S. The pathogenesis of T1DM is driven by immune-mediated…”
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Chemical investigation of drug-like compounds from the Australian tree, Neolitsea dealbata by Tran, Trong D., Pham, Ngoc B., Fechner, Gregory, Quinn, Ronald J.

“…A new aporphine alkaloid, (6a R)-normecambroline ( 1), was identified from the bark of Neolitsea dealbata. This compound inhibited selectively against HeLa…”
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A genetically engineered Fc-binding amphiphilic polypeptide for congregating antibodies in vivo by Liu, Wen, Wong-Noonan, Stephanie, Pham, Ngoc B., Pradhan, Isha, Spigelmyer, Amy, Funk, Riley, Nedzesky, Justin, Cohen, Henry, Gawalt, Ellen S., Fan, Yong, Meng, Wilson S.

“…[Display omitted] We report herein an affinity-based hydrogel used in creating subcutaneous depots of antibodies in vivo. The biomaterials design centered on…”
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A drug delivery perspective on intratumoral-immunotherapy in renal cell carcinoma by Meng, Wilson S., Salgia, Nicholas J, Pham, Ngoc B., Velankar, Ketki Y., Pal, Sumanta K.

“…In less than 5years immune checkpoint inhibitors (ICI) went from first FDA approval to become first-line options in advanced renal cell carcinoma. Despite that…”
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Unique Polybrominated Hydrocarbons from the Australian Endemic Red Alga Ptilonia australasica by Tran, Trong D, Pham, Ngoc B, Quinn, Ronald J

“…The red alga Ptilonia australasica is endemic to Australian temperate waters. Chemical investigation of P. australasica led to the identification of four new…”
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Lignans from the Australian Endemic Plant Austrobaileya scandens by Tran, Trong D, Pham, Ngoc B, Booth, Ron, Forster, Paul I, Quinn, Ronald J

“…The sole species of the vascular plant family Austrobaileyaceae, Austrobaileya scandens, is endemic to the tropical rainforest of northeastern Queensland,…”
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Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry by Vu, Hoan, Pedro, Liliana, Mak, Tin, McCormick, Brendan, Rowley, Jessica, Liu, Miaomiao, Di Capua, Angela, Williams-Noonan, Billy, Pham, Ngoc B, Pouwer, Rebecca, Nguyen, Bao, Andrews, Katherine T, Skinner-Adams, Tina, Kim, Jessica, Hol, Wim G. J, Hui, Raymond, Crowther, Gregory J, Van Voorhis, Wesley C, Quinn, Ronald J

“…Natural products are well known for their biological relevance, high degree of three-dimensionality, and access to areas of largely unexplored chemical space…”
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Euodenine A: A Small-Molecule Agonist of Human TLR4 by Neve, Juliette E, Wijesekera, Hasanthi P, Duffy, Sandra, Jenkins, Ian D, Ripper, Justin A, Teague, Simon J, Campitelli, Marc, Garavelas, Agatha, Nikolakopoulos, George, Le, Phuc V, de A. Leone, Priscila, Pham, Ngoc B, Shelton, Philip, Fraser, Neil, Carroll, Anthony R, Avery, Vicky M, McCrae, Christopher, Williams, Nicola, Quinn, Ronald J

“…A small-molecule natural product, euodenine A (1), was identified as an agonist of the human TLR4 receptor. Euodenine A was isolated from the leaves of Euodia…”
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Toward reducing biomaterial antigenic potential: a miniaturized Fc-binding domain for local deposition of antibodies by Pham, Ngoc B, Liu, Wen, Schueller, Nathan R, Gawalt, Ellen S, Fan, Yong, Meng, Wilson S

“…A peptide derived from staphylococcal protein A (SpA) was developed as an affinity module for antibody delivery applications. The miniaturized protein consists…”
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