Search Results - "Pham, Christine T N"
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Neutrophil serine proteases: specific regulators of inflammation
Published in Nature Reviews: Immunology (01-07-2006)“…Neutrophils are essential for host defence against invading pathogens. They engulf and degrade microorganisms using an array of weapons that include reactive…”
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2
Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy
Published in The Journal of immunology (1950) (15-04-2018)“…Factor D (FD) is an essential component of the complement alternative pathway (AP). It is an attractive pharmaceutical target because it is an AP-specific…”
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3
Caspase-1-driven neutrophil pyroptosis and its role in host susceptibility to Pseudomonas aeruginosa
Published in PLoS pathogens (18-07-2022)“…Multiple regulated neutrophil cell death programs contribute to host defense against infections. However, despite expressing all necessary inflammasome…”
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4
Rapamycin Perfluorocarbon Nanoparticle Mitigates Cisplatin-Induced Acute Kidney Injury
Published in International journal of molecular sciences (23-03-2023)“…For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients…”
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5
Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice
Published in PloS one (13-02-2017)“…Estrogen, a natural immunomodulator, regulates the development and function of diverse immune cell types. There is now renewed attention on neutrophils and…”
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6
Non-invasive monitoring of arthritis treatment response via targeting of tyrosine-phosphorylated annexin A2 in chondrocytes
Published in Arthritis research & therapy (25-10-2021)“…The development and optimization of therapies for rheumatoid arthritis (RA) is currently hindered by a lack of methods for early non-invasive monitoring of…”
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7
Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm
Published in Proceedings of the National Academy of Sciences - PNAS (14-02-2012)“…Abdominal aortic aneurysm (AAA) is a complex inflammatory vascular disease. There are currently limited treatment options for AAA when surgery is inapplicable…”
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8
Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles
Published in Bioconjugate chemistry (19-08-2015)“…Melittin is a cytolytic peptide derived from bee venom that inserts into lipid membranes and oligomerizes to form membrane pores. Although this peptide is an…”
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Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice
Published in Nanomaterials (Basel, Switzerland) (31-10-2024)“…Nanomedicine holds great potential for revolutionizing medical treatment. Ongoing research and advancements in nanotechnology are continuously expanding the…”
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10
Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense
Published in PloS one (07-12-2011)“…NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in regulating inflammation. Patients with chronic granulomatous disease, an…”
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11
Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy
Published in Gels (01-02-2023)“…Biologic therapies have revolutionized treatment options for rheumatoid arthritis (RA) but their continuous administration at high doses may lead to adverse…”
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12
Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms
Published in Proceedings of the National Academy of Sciences - PNAS (20-02-2007)“…Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease critical for the activation of granule-associated serine proteases, including neutrophil…”
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13
Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle‐Based Small Interfering RNA
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-12-2021)“…Objective Recent evidence delineates an emerging role of periostin in osteoarthritis (OA), since its expression after knee injury is detrimental to the…”
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14
Dipeptidyl Peptidase I-Dependent Neutrophil Recruitment Modulates the Inflammatory Response to Sendai Virus Infection
Published in The Journal of immunology (1950) (01-03-2008)“…The role of innate immunity in the pathogenesis of asthma is unclear. Although increased presence of neutrophils is associated with persistent asthma and…”
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15
Neutrophil Serine Proteases Promote IL-1β Generation and Injury in Necrotizing Crescentic Glomerulonephritis
Published in Journal of the American Society of Nephrology (01-03-2012)“…The pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated necrotizing crescentic GN (NCGN) is incompletely understood. Dipeptidyl peptidase I…”
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16
Fumagillin Prodrug Nanotherapy Suppresses Macrophage Inflammatory Response via Endothelial Nitric Oxide
Published in ACS nano (22-07-2014)“…Antiangiogenesis has been extensively explored for the treatment of a variety of cancers and certain inflammatory processes. Fumagillin, a mycotoxin produced…”
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Designer Stem Cells: Genome Engineering and the Next Generation of Cell‐Based Therapies
Published in Journal of orthopaedic research (01-06-2019)“…ABSTRACT Stem cells provide tremendous promise for the development of new therapeutic approaches for musculoskeletal conditions. In addition to their…”
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18
Size-Dependent Effective Diffusivity in Healthy Human and Porcine Joint Synovium
Published in Annals of biomedical engineering (01-04-2021)“…Intra-articular drug delivery can be effective in targeting a diseased joint but is hampered by rapid clearance times from the diarthrodial joint. The synovium…”
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19
Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery
Published in Scientific reports (24-01-2019)“…Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular…”
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Correction to: Size-Dependent Effective Diffusivity in Healthy Human and Porcine Joint Synovium
Published in Annals of biomedical engineering (01-04-2022)Get full text
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