Search Results - "Pham, Christine T N"

Refine Results
  1. 1

    Neutrophil serine proteases: specific regulators of inflammation by Pham, Christine T. N

    Published in Nature Reviews: Immunology (01-07-2006)
    “…Neutrophils are essential for host defence against invading pathogens. They engulf and degrade microorganisms using an array of weapons that include reactive…”
    Get full text
    Journal Article
  2. 2

    Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy by Wu, Xiaobo, Hutson, Irina, Akk, Antonina M, Mascharak, Smita, Pham, Christine T N, Hourcade, Dennis E, Brown, Rebecca, Atkinson, John P, Harris, Charles A

    Published in The Journal of immunology (1950) (15-04-2018)
    “…Factor D (FD) is an essential component of the complement alternative pathway (AP). It is an attractive pharmaceutical target because it is an AP-specific…”
    Get full text
    Journal Article
  3. 3
  4. 4

    Rapamycin Perfluorocarbon Nanoparticle Mitigates Cisplatin-Induced Acute Kidney Injury by Zhou, Qingyu, Quirk, James D, Hu, Ying, Yan, Huimin, Gaut, Joseph P, Pham, Christine T N, Wickline, Samuel A, Pan, Hua

    “…For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients…”
    Get full text
    Journal Article
  5. 5

    Neutrophils and neutrophil serine proteases are increased in the spleens of estrogen-treated C57BL/6 mice and several strains of spontaneous lupus-prone mice by Dai, Rujuan, Cowan, Catharine, Heid, Bettina, Khan, Deena, Liang, Zhihong, Pham, Christine T N, Ahmed, S Ansar

    Published in PloS one (13-02-2017)
    “…Estrogen, a natural immunomodulator, regulates the development and function of diverse immune cell types. There is now renewed attention on neutrophils and…”
    Get full text
    Journal Article
  6. 6

    Non-invasive monitoring of arthritis treatment response via targeting of tyrosine-phosphorylated annexin A2 in chondrocytes by Tsen, Shaw-Wei D, Springer, Luke E, Sharmah Gautam, Krishna, Tang, Rui, Liang, Kexian, Sudlow, Gail, Kucharski, Amir, Pham, Christine T N, Achilefu, Samuel

    Published in Arthritis research & therapy (25-10-2021)
    “…The development and optimization of therapies for rheumatoid arthritis (RA) is currently hindered by a lack of methods for early non-invasive monitoring of…”
    Get full text
    Journal Article
  7. 7
  8. 8

    Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles by Jallouk, Andrew P, Palekar, Rohun U, Marsh, Jon N, Pan, Hua, Pham, Christine T. N, Schlesinger, Paul H, Wickline, Samuel A

    Published in Bioconjugate chemistry (19-08-2015)
    “…Melittin is a cytolytic peptide derived from bee venom that inserts into lipid membranes and oligomerizes to form membrane pores. Although this peptide is an…”
    Get full text
    Journal Article
  9. 9

    Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice by Zhou, Qingyu, Harding, John C, Fan, Ping, Spasojevic, Ivan, Kovacs, Attila, Akk, Antonina, Mitchell, Adam, Springer, Luke E, Gaut, Joseph P, Rauch, Daniel A, Wickline, Samuel A, Pham, Christine T. N, Fuh, Katherine, Pan, Hua

    Published in Nanomaterials (Basel, Switzerland) (31-10-2024)
    “…Nanomedicine holds great potential for revolutionizing medical treatment. Ongoing research and advancements in nanotechnology are continuously expanding the…”
    Get full text
    Journal Article
  10. 10

    Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense by Vethanayagam, R Robert, Almyroudis, Nikolaos G, Grimm, Melissa J, Lewandowski, David C, Pham, Christine T N, Blackwell, Timothy S, Petraitiene, Ruta, Petraitis, Vidmantas, Walsh, Thomas J, Urban, Constantin F, Segal, Brahm H

    Published in PloS one (07-12-2011)
    “…NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in regulating inflammation. Patients with chronic granulomatous disease, an…”
    Get full text
    Journal Article
  11. 11

    Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy by Collins, Kelsey H, Pferdehirt, Lara, Saleh, Leila S, Savadipour, Alireza, Springer, Luke E, Lenz, Kristin L, Thompson, Jr, Dominic M, Oswald, Sara J, Pham, Christine T N, Guilak, Farshid

    Published in Gels (01-02-2023)
    “…Biologic therapies have revolutionized treatment options for rheumatoid arthritis (RA) but their continuous administration at high doses may lead to adverse…”
    Get full text
    Journal Article
  12. 12

    Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms by Pagano, Monica B, Bartoli, Michel A, Ennis, Terri L, Mao, Dongli, Simmons, Pamela M, Thompson, Robert W, Pham, Christine T.N

    “…Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease critical for the activation of granule-associated serine proteases, including neutrophil…”
    Get full text
    Journal Article
  13. 13

    Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle‐Based Small Interfering RNA by Duan, Xin, Cai, Lei, Pham, Christine T. N., Abu‐Amer, Yousef, Pan, Hua, Brophy, Robert H., Wickline, Samuel A., Rai, Muhammad Farooq

    Published in Arthritis & rheumatology (Hoboken, N.J.) (01-12-2021)
    “…Objective Recent evidence delineates an emerging role of periostin in osteoarthritis (OA), since its expression after knee injury is detrimental to the…”
    Get full text
    Journal Article
  14. 14

    Dipeptidyl Peptidase I-Dependent Neutrophil Recruitment Modulates the Inflammatory Response to Sendai Virus Infection by Akk, Antonina M, Simmons, Pamela M, Chan, Happy W, Agapov, Eugene, Holtzman, Michael J, Grayson, Mitchell H, Pham, Christine T. N

    Published in The Journal of immunology (1950) (01-03-2008)
    “…The role of innate immunity in the pathogenesis of asthma is unclear. Although increased presence of neutrophils is associated with persistent asthma and…”
    Get full text
    Journal Article
  15. 15

    Neutrophil Serine Proteases Promote IL-1β Generation and Injury in Necrotizing Crescentic Glomerulonephritis by SCHREIBER, Adrian, PHAM, Christine T. N, YING HU, SCHNEIDER, Wolfgang, LUFT, Friedrich C, KETTRITZ, Ralph

    “…The pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated necrotizing crescentic GN (NCGN) is incompletely understood. Dipeptidyl peptidase I…”
    Get full text
    Journal Article
  16. 16

    Fumagillin Prodrug Nanotherapy Suppresses Macrophage Inflammatory Response via Endothelial Nitric Oxide by Zhou, Hui-fang, Yan, Huimin, Hu, Ying, Springer, Luke E, Yang, Xiaoxia, Wickline, Samuel A, Pan, Dipanjan, Lanza, Gregory M, Pham, Christine T. N

    Published in ACS nano (22-07-2014)
    “…Antiangiogenesis has been extensively explored for the treatment of a variety of cancers and certain inflammatory processes. Fumagillin, a mycotoxin produced…”
    Get full text
    Journal Article
  17. 17

    Designer Stem Cells: Genome Engineering and the Next Generation of Cell‐Based Therapies by Guilak, Farshid, Pferdehirt, Lara, Ross, Alison K., Choi, Yun‐Rak, Collins, KelseyH, Nims, Robert J., Katz, Dakota B., Klimak, Molly, Tabbaa, Suzanne, Pham, Christine T. N.

    Published in Journal of orthopaedic research (01-06-2019)
    “…ABSTRACT Stem cells provide tremendous promise for the development of new therapeutic approaches for musculoskeletal conditions. In addition to their…”
    Get full text
    Journal Article
  18. 18

    Size-Dependent Effective Diffusivity in Healthy Human and Porcine Joint Synovium by Guang, Young, Davis, Alexandra L., McGrath, Thomas M., Pham, Christine T. N., Fitzpatrick, James A. J., Setton, Lori A.

    Published in Annals of biomedical engineering (01-04-2021)
    “…Intra-articular drug delivery can be effective in targeting a diseased joint but is hampered by rapid clearance times from the diarthrodial joint. The synovium…”
    Get full text
    Journal Article
  19. 19

    Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery by Yan, Huimin, Duan, Xin, Pan, Hua, Akk, Antonina, Sandell, Linda J., Wickline, Samuel A., Rai, Muhammad Farooq, Pham, Christine T. N.

    Published in Scientific reports (24-01-2019)
    “…Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular…”
    Get full text
    Journal Article
  20. 20