Search Results - "Pflugfelder, S C"

IL-17 disrupts corneal barrier following desiccating stress by De Paiva, C S, Chotikavanich, S, Pangelinan, S B, Pitcher, J D, Fang, B, Zheng, X, Ma, P, Farley, W J, Siemasko, K F, Niederkorn, J Y, Stern, M E, Li, D-Q, Pflugfelder, S C

“…T helper (Th)-17 is a recently identified subtype of Th response that has been implicated in host defense and autoimmunity. We investigated whether there is…”
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Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation by Su, Z, Lin, J, Lu, F, Zhang, X, Zhang, L, Gandhi, N B, de Paiva, C S, Pflugfelder, S C, Li, D-Q

“…This study identified a novel phenomenon that dendritic cells (DCs) produced interleukin (IL)-33 via Toll-like receptor (TLR)-mediated innate pathway. Mouse…”
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Pro- and Anti-inflammatory Forms of Interleukin-1 in the Tear Fluid and Conjunctiva of Patients with Dry-Eye Disease by Solomon, Abraham, Dursun, Dilek, Liu, Zuguo, Xie, Yuhuan, Macri, Angelo, Pflugfelder, Stephen C

“…To compare the expression of the pro- and anti-inflammatory forms of interleukin (IL)-1 in the tear fluid and conjunctival epithelium of normal eyes and those…”
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Autoimmunity at the ocular surface: pathogenesis and regulation by Stern, M E, Schaumburg, C S, Dana, R, Calonge, M, Niederkorn, J Y, Pflugfelder, S C

“…A healthy ocular surface environment is essential to preserve visual function, and as such the eye has evolved a complex network of mechanisms to maintain…”
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Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13 by De Paiva, C S, Raince, J K, McClellan, A J, Shanmugam, K P, Pangelinan, S B, Volpe, E A, Corrales, R M, Farley, W J, Corry, D B, Li, D-Q, Pflugfelder, S C

“…Although the effects of the interleukin 13 (IL-13) on goblet cell (GC) hyperplasia have been studied in the gut and respiratory tracts, its effect on…”
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Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndrome by Marsh, P, Pflugfelder, S C

“…To review the efficacy and side effects of topical nonpreserved corticosteroid therapy for treatment of severe keratoconjunctivitis associated with Sjögren…”
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Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation by Ganugula, R, Arora, M, Lepiz, M A, Niu, Y, Mallick, B K, Pflugfelder, S C, Scott, E M, Kumar, M N V Ravi

“…Novel approaches circumventing blood-ocular barriers in systemic drug delivery are lacking. We hypothesize receptor-mediated delivery of curcumin (CUR) across…”
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Evaluation of corneal thickness and topography in normal eyes using the Orbscan corneal topography system by Liu, Zuguo, Huang, Andrew J, Pflugfelder, Stephen C

“…AIMS To map the thickness, elevation (anterior and posterior corneal surface), and axial curvature of the cornea in normal eyes with the Orbscan corneal…”
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Doxycycline Inhibition of Interleukin-1 in the Corneal Epithelium by Solomon, Abraham, Rosenblatt, Mark, Li, De-Quan, Liu, Zuguo, Monroy, Dagoberto, Ji, Zhonghua, Lokeshwar, Balakrishna L, Pflugfelder, Stephen C

“…To evaluate the effect of doxycycline on the regulation of interleukin (IL)-1 expression and activity in human cultured corneal epithelium. Human corneal…”
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Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation by Pflugfelder, S C, Tseng, S C, Yoshino, K, Monroy, D, Felix, C, Reis, B L

“…This study was designed to compare goblet cell densities and mucosal epithelial membrane mucin (MEM) expression in impression cytology specimens obtained from…”
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The effects of long-term contact lens wear on corneal thickness, curvature, and surface regularity by Liu, Z, Pflugfelder, S C

“…To evaluate the effect of long-term contact lens wear on corneal thickness, curvature, and surface regularity. A prospective, clinic-based, case-control study…”
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Rationale for anti-inflammatory therapy in dry eye syndrome by de Paiva, C S, Pflugfelder, S C

“…Dry eye is a multifactorial condition that results in a dysfunctional lacrimal functional unit. Evidence suggests that inflammation is involved in the…”
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Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice by Yeh, S, de Paiva, C S, Hwang, C S, Trinca, K, Lingappan, A, Rafati, J K, Farley, W J, Li, D-Q, Pflugfelder, S C

“…Patients with autoimmune polyendocrinopathy-candiasis-ectodermal dystrophy (APECED) develop severe keratoconjunctivitis, corneal scarring and visual loss, but…”
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Expression of glial cell-derived neurotrophic factor and its receptor in the stem-cell-containing human limbal epithelium by Qi, H, Li, D-Q, Bian, F, Chuang, E Y, Jones, D B, Pflugfelder, S C

“…To evaluate the expression pattern of glial cell line-derived neurotrophic factor (GDNF) with its receptors GDNF family receptor alpha-1 (GFR alpha-1) and Ret…”
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Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency by Liu, Z, Pflugfelder, S C

“…To evaluate corneal surface regularity and the effect of artificial tears on the regularity of the corneal surface in dry eye. A prospective, clinic-based,…”
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Inflammatory cytokines in the tears of patients with ocular rosacea by Barton, K, Monroy, D C, Nava, A, Pflugfelder, S C

“…The purpose of the study is to compare tear fluid concentrations of interleukin-1alpha (IL-1alpha), tumor necrosis factor-alpha (TNF-alpha), and epidermal…”
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Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells by Coursey, T G, Bian, F, Zaheer, M, Pflugfelder, S C, Volpe, E A, de Paiva, C S

“…In both humans and animal models, the development of Sjögren syndrome (SS) and non-SS keratoconjunctivitis sicca (KCS) increases with age. Here, we…”
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Sjogren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium by Jones, DT, Monroy, D, Ji, Z, Atherton, SS, Pflugfelder, SC

“…In primary Sjögren's syndrome (SS), ocular surface changes within the conjunctival epithelium include lymphocytic infiltration, squamous cell metaplasia, and a…”
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Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca by Pflugfelder, Stephen C., Jones, David, Ji, Zhonghua, Afonso, Adolfo, Monroy, Dagoberto

“…PURPOSE. To compare epidermal growth factor (EGF) concentration in tear fluid and levels of inflammatory cytokines in the conjunctival epithelium of patients…”
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A hyaluronan hydrogel scaffold-based xeno-free culture system for ex vivo expansion of human corneal epithelial stem cells by Chen, D, Qu, Y, Hua, X, Zhang, L, Liu, Z, Pflugfelder, S C, Li, D-Q

“…Purpose To develop a hyaluronan hydrogel scaffold-based xeno-free culture system for ex vivo cultivation of human corneal epithelial stem cells (CESCs)…”
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