Search Results - "Pflégr, Václav"

Synthesis and Antimycobacterial Activity of Isoniazid Derivatives Tethered with Aliphatic Amines by Pflégr, Václav, Stolaříková, Jiřina, Vinšová, Jarmila, Krátký, Martin

“…There is an urgent need for new antitubercular compounds. Modification of antimycobacterial isonicotinohydrazide at hydrazide N2 provided antimycobacterial…”
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Design and synthesis of 2-(2-isonicotinoylhydrazineylidene)propanamides as InhA inhibitors with high antitubercular activity by Pflégr, Václav, Horváth, Lilla, Stolaříková, Jiřina, Pál, Adrián, Korduláková, Jana, Bősze, Szilvia, Vinšová, Jarmila, Krátký, Martin

“…Based on successful antitubercular isoniazid scaffold we have designed its “mee-too” analogues by a combination of this drug linked with substituted anilines…”
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Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents by Krátký, Martin, Konečná, Klára, Brablíková, Michaela, Janoušek, Jiří, Pflégr, Václav, Maixnerová, Jana, Trejtnar, František, Vinšová, Jarmila

“…[Display omitted] •Iodinated hydrazide-hydrazones and diacylhydrazines were obtained via condensation.•Activity against Gram-positive bacteria including MRSA…”
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Novel pyrimidine-1,3,4-oxadiazole hybrids and their precursors as potential antimycobacterial agents by Pflégr, Václav, Stolaříková, Jiřina, Pál, Adrián, Korduláková, Jana, Krátký, Martin

“…Molecular hybridization and isostery are proven approaches in medicinal chemistry, and as such we used them to design novel compounds that we investigated as…”
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N-[3,5-Bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxybenzamide Analogues: Novel Acetyl- and Butyrylcholinesterase Inhibitors by Krátký, Martin, Jaklová, Karolína, Štěpánková, Šárka, Svrčková, Katarína, Pflégr, Václav, Vinšová, Jarmila

“…Development of acetyl- (AChE) and butyrylcholinesterase (BuChE) inhibitors belongs to viable strategies for the treatment of dementia and other diseases…”
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5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study by Pflégr, Václav, Štěpánková, Šárka, Svrčková, Katarína, Švarcová, Markéta, Vinšová, Jarmila, Krátký, Martin

“…2,5-Disubstituted 1,3,4-oxadiazoles are privileged versatile scaffolds in medicinal chemistry that have exhibited diverse biological activities. Acetyl- (AChE)…”
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Host cell targeting of novel antimycobacterial 4-aminosalicylic acid derivatives with tuftsin carrier peptides by Borbála Horváth, Lilla, Krátký, Martin, Pflégr, Václav, Méhes, Előd, Gyulai, Gergő, Kohut, Gergely, Babiczky, Ákos, Biri-Kovács, Beáta, Baranyai, Zsuzsa, Vinšová, Jarmila, Bősze, Szilvia

“…[Display omitted] •Design, synthesis, and characterization of new antimycobacterial 4-aminosalicylic acid derivatives.•New tuftsin bioconjugates targeting cell…”
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Novel Inhibitors of Acetyl- and Butyrylcholinesterase Derived from Benzohydrazides: Synthesis, Evaluation and Docking Study by Houngbedji, Neto-Honorius, Štěpánková, Šárka, Pflégr, Václav, Svrčková, Katarína, Švarcová, Markéta, Vinšová, Jarmila, Krátký, Martin

“…On the basis of previous reports, novel 2-benzoylhydrazine-1-carboxamides were designed as potential inhibitors of acetylcholinesterase (AChE) and…”
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Novel propargylamine-based inhibitors of cholinesterases and monoamine oxidases: Synthesis, biological evaluation and docking study by Krátký, Martin, Vu, Quynh Anh, Štěpánková, Šárka, Maruca, Annalisa, Silva, Tiago Barros, Ambrož, Martin, Pflégr, Václav, Rocca, Roberta, Svrčková, Katarína, Alcaro, Stefano, Borges, Fernanda, Vinšová, Jarmila

“…[Display omitted] •New compounds combine propargylamine and salicylic/cinnamic scaffolds.•The compounds exhibited dual inhibition of AChE, BuChE and…”
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Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid by Pflégr, Václav, Maixnerová, Jana, Stolaříková, Jiřina, Pál, Adrián, Korduláková, Jana, Trejtnar, František, Vinšová, Jarmila, Krátký, Martin

“…The combination of two active scaffolds into one molecule represents a proven approach in drug design to overcome microbial drug resistance. We designed and…”
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