Search Results - "Pfizenmayer, Amy J."

Synthesis of New Didemnin B Analogs for Investigations of Structure/Biological Activity Relationships by Mayer, Scott C, Ramanjulu, Joshi, Vera, Matthew D, Pfizenmayer, Amy J, Joullie, Madeleine M

Get full text

Total Syntheses of Conformationally Constrained Didemnin B Analogues. Replacements of N,O-Dimethyltyrosine with l-1,2,3,4-Tetrahydroisoquinoline and l-1,2,3,4-Tetrahydro-7-methoxyisoquinoline by Tarver, James E, Pfizenmayer, Amy J, Joullié, Madeleine M

“…The design and synthesis of two conformationally constrained analogues of didemnin B are described. The [N,O-Me2Tyr5]residue of didemnin B was replaced with…”
Get full text

[Lys 3]didemnins as potential affinity ligands by Vera, Matthew D, Pfizenmayer, Amy J, Ding, Xiaobin, Xiao, Dong, Joullié, Madeleine M

“…The synthesis and biological activity of N ε-Z-[Lys 3]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and protein…”
Get full text

Synthetic Routes to a Constrained Ring Analog of Didemnin B by Mayer, Scott C, Pfizenmayer, Amy J, Joullié, Madeleine M

“…The didemnin class of biologically active cyclodepsipeptides, isolated from a marine tunicate, has shown antitumor, antiviral, and immunosuppressive…”
Get full text

Synthesis and biological evaluation of didemnin photo affinity analogues by VERA, Matthew D, PFIZENMAYER, Amy J, XIAOBIN DING, AHUJA, Deepika, TOOGOOD, Peter L, JOULLIE, Madeleine M

Get full text

Synthesis and biological evaluation of didemnin photoaffinity analogues by Vera, M D, Pfizenmayer, A J, Ding, X, Ahuja, D, Toogood, P L, Joullié, M M

“…The synthesis of four benzophenone-containing analogues of the antiproliferative natural product didemnin B is presented. In vitro protein biosynthesis…”
Get full text

Synthesis and biological activities of [ N-MeLeu 5]- and [ N-MePhe 5]-didemnin B by Pfizenmayer, Amy J., Ramanjulu, Joshi M., Vera, Matthew D., Ding, Xiaobin, Xiao, Dong, Wei-Chuan, Chen, Joullié, Madeleine M.

“…Based on information from X-ray, NMR, and SAR data, the N, O-diMeTyr 5 unit of didemnin B was believed to be important for biological activity. To determine…”
Get full text

Stereoselective synthesis of a conformationally restricted β-hydroxy-λ-amino acid by Xiao, Dong, Carroll, Patrick J., Mayer, Scott C., Pfizenmayer, Amy J., Joullié, Madeleine M.

“…β-Hydroxy-λ-amino acids are a class of non-proteinogenic amino acids present in many important biologically active natural products. In conjunction with our…”
Get full text

Synthesis and biological activity of [Tic 5] didemnin B by Pfizenmayer, Amy J., Vera, Matthew D., Ding, Xiaobin, Xiao, Dong, Chen, Wei-Chuan, Joullié, Madeleine M., Tandon, Deepika, Toogood, Peter L.

“…A didemnin B analog containing a Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) as a conformationally restrained replacement for tyrosine has been…”
Get full text

Synthesis and biological activities of [ N-MeLeu 5] didemnin B by Pfizenmayer, Amy J., Ramanjulu, Joshi, Vera, Matthew D., Ding, Xiaobin, Xiao, Dong, Chen, Wei-Chuan, Joullié, Madeleine M.

“…Based on information from X-ray, NMR, and SAR data, the N,O-diMeTyr 5 unit of didemnim B was believed to interact with receptors. To ascertain the importance…”
Get full text