Search Results - "Pfizenmayer, A."
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Storm-related sea level variations along the North Sea coast: natural variability and anthropogenic change
Published in Continental shelf research (01-05-1999)“…The influence of a changing wind climate on the sea surface elevations along the North Sea coast was investigated, with a statistical down-scaling technique…”
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Changing Waves and Storms in the Northeast Atlantic?
Published in Bulletin of the American Meteorological Society (01-05-1998)“…The European project WASA (Waves and Storms in the North Atlantic) has been set up to verify or disprove hypotheses of a worsening storm and wave climate in…”
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3
Anthropogenic climate change shown by local wave conditions in the North Sea
Published in Climate research (22-11-2001)“…In the central North Sea we have observed an increase in the frequency of eastwardly propagating waves in the last 4 decades. To assess the significance of…”
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4
Inhibition of Protein Synthesis by Didemnins: Cell Potency and SAR
Published in Journal of medicinal chemistry (02-11-2000)“…Synthetic and naturally occurring didemnins are potent and specific inhibitors of protein synthesis in vitro. Structure−activity analysis indicates a…”
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Synthesis and biological activity of [Tic 5] didemnin B
Published in Bioorganic & medicinal chemistry letters (15-12-1998)“…A didemnin B analog containing a Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) as a conformationally restrained replacement for tyrosine has been…”
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6
Total Syntheses of Conformationally Constrained Didemnin B Analogues. Replacements of N,O-Dimethyltyrosine with l-1,2,3,4-Tetrahydroisoquinoline and l-1,2,3,4-Tetrahydro-7-methoxyisoquinoline
Published in Journal of organic chemistry (16-11-2001)“…The design and synthesis of two conformationally constrained analogues of didemnin B are described. The [N,O-Me2Tyr5]residue of didemnin B was replaced with…”
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Synthesis and biological evaluation of didemnin photoaffinity analogues
Published in Bioorganic & medicinal chemistry letters (23-07-2001)“…The synthesis of four benzophenone-containing analogues of the antiproliferative natural product didemnin B is presented. In vitro protein biosynthesis…”
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Synthesis of New Didemnin B Analogs for Investigations of Structure/Biological Activity Relationships
Published in Journal of organic chemistry (01-09-1994)Get full text
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[Lys 3]didemnins as potential affinity ligands
Published in Bioorganic & medicinal chemistry letters (08-01-2001)“…The synthesis and biological activity of N ε-Z-[Lys 3]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and protein…”
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Synthesis and biological activities of [ N-MeLeu 5]- and [ N-MePhe 5]-didemnin B
Published in Tetrahedron (08-01-1999)“…Based on information from X-ray, NMR, and SAR data, the N, O-diMeTyr 5 unit of didemnin B was believed to be important for biological activity. To determine…”
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11
Synthetic Routes to a Constrained Ring Analog of Didemnin B
Published in Journal of organic chemistry (08-03-1996)“…The didemnin class of biologically active cyclodepsipeptides, isolated from a marine tunicate, has shown antitumor, antiviral, and immunosuppressive…”
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12
Synthesis and biological activities of [ N-MeLeu 5] didemnin B
Published in Bioorganic & medicinal chemistry letters (19-11-1996)“…Based on information from X-ray, NMR, and SAR data, the N,O-diMeTyr 5 unit of didemnim B was believed to interact with receptors. To ascertain the importance…”
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