Search Results - "Pfizenmaier, K."

Tumor necrosis factor signaling by Wajant, H, Pfizenmaier, K, Scheurich, P

“…A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50,000 articles providing one or the other information about this…”
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Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L by Berg, D, Lehne, M, Müller, N, Siegmund, D, Münkel, S, Sebald, W, Pfizenmaier, K, Wajant, H

“…Variants of human TRAIL (hTRAIL) and human CD95L (hCD95L), encompassing the TNF homology domain (THD), interact with the corresponding receptors and stimulate…”
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TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy by Wajant, H, Pfizenmaier, K, Scheurich, P

“…TNF-related apoptosis-inducing ligand (TRAIL/APO-2L) is a typical member of the TNF ligand family that induces apoptosis by activating the death receptors…”
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An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes by Becker, Eric, Florin, Lore, Pfizenmaier, Klaus, Kaufmann, Hitto

“…The optimization of production processes for therapeutic antibodies is a continuing challenge in pharmaceutical biotechnology. Although it could be…”
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OMTX705, a powerful stroma-targeting ADC to treat invasive tumors with low response to immunotherapeutic anti-PD-1 treatments by Fabre, M., Ferrer, C., Dominguez-Hormaetxe, S., Kontermann, R., Pfizenmaier, K., Seifert, O., López-Casas, P.P., Abbas, M., Richter, W., Simon, L., Hidalgo, M.

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Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice by Chertoff, M., Di Paolo, N., Schoeneberg, A., Depino, A., Ferrari, C., Wurst, W., Pfizenmaier, K., Eisel, U., Pitossi, F.

“…Tumor necrosis factor (TNF)-α, a pro-inflammatory cytokine, has been implicated in both neuronal death and survival in Parkinson's disease (PD). The substantia…”
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Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity by Siegemund, M, Pollak, N, Seifert, O, Wahl, K, Hanak, K, Vogel, A, Nussler, A K, Göttsch, D, Münkel, S, Bantel, H, Kontermann, R E, Pfizenmaier, K

“…Although targeting of the death receptors (DRs) DR4 and DR5 still appears a suitable antitumoral strategy, the limited clinical responses to recombinant…”
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Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins by Schneider, B, Münkel, S, Krippner-Heidenreich, A, Grunwald, I, Wels, W S, Wajant, H, Pfizenmaier, K, Gerspach, J

“…In an attempt to improve TRAIL's (tumor necrosis factor-related apoptosis-inducing ligand) tumor selective activity a variant was designed, in which the three…”
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PKC zeta is a molecular switch in signal transduction of TNF‐alpha, bifunctionally regulated by ceramide and arachidonic acid by Müller, G., Ayoub, M., Storz, P., Rennecke, J., Fabbro, D., Pfizenmaier, K.

“…Tumor necrosis factor (TNF‐alpha) stimulates a number of signal transduction pathways in which phospholipases produce lipid second messengers. However, the…”
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Activation of CD95L fusion protein prodrugs by tumor-associated proteases by Watermann, I, Gerspach, J, Lehne, M, Seufert, J, Schneider, B, Pfizenmaier, K, Wajant, H

“…To achieve tumor cell-restricted activation of CD95, we developed a CD95L fusion protein format, in which CD95L activity is only unmasked upon…”
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PKCu is a novel, atypical member of the protein kinase C family by JOHANNES, F.-J, PRESTLE, J, EIS, S, OBERHAGEMANN, P, PIFZENMAIER, K

“…We have isolated the full-length cDNA of a novel human serine/threonine protein kinase gene. The deduced protein sequence shows strong homology to conserved…”
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Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha- mediated enhancement of T cell responses by Scheurich, P, Thoma, B, Ucer, U, Pfizenmaier, K

“…The expression of specific tumor necrosis factor (TNF) membrane receptors and biological effects of recombinant TNF (rTNF)-alpha on normal human T lymphocytes…”
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Protein Kinase C μ Is Regulated by the Multifunctional Chaperon Protein p32 by Storz, Peter, Hausser, Angelika, Link, Gisela, Dedio, Jürgen, Ghebrehiwet, Berhane, Pfizenmaier, Klaus, Johannes, Franz-Josef

“…We identified the multifunctional chaperon protein p32 as a protein kinase C (PKC)-binding protein interacting with PKCα, PKCζ, PKCδ, and PKCμ. We have…”
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An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action by Berger, V., Richter, F., Zettlitz, K., Unverdorben, F., Scheurich, P., Herrmann, A., Pfizenmaier, K., Kontermann, R. E.

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Construction of a bispecific single chain antibody for recruitment of cytotoxic T cells to the tumour stroma associated antigen fibroblast activation protein by Wüest, Thomas, Moosmayer, Dieter, Pfizenmaier, Klaus

“…Bispecific antibodies directed against tumour associated antigens and the T cell receptor component CD3 for recruitment and tumour targeted activation of T…”
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Protein Kinase C μ Is Located at the Golgi Compartment by Prestle, Jürgen, Pfizenmaier, Klaus, Brenner, Joachim, Johannes, Franz-Josef

“…Protein kinase C μ (PKCμ) displays unusual structural features like a pleckstrin homology domain and an amino-terminal hydrophobic region with a putative…”
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TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways by Grell, M, Zimmermann, G, Hulser, D, Pfizenmaier, K, Scheurich, P

“…TNF membrane receptors are usually co-expressed in many tissues but their relative contribution to cellular TNF responses is for most situations unknown. In a…”
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Species-crossreactive scFv against the tumor stroma marker "fibroblast activation protein" selected by phage display from an immunized FAP-/- knock-out mouse by Brocks, B, Garin-Chesa, P, Behrle, E, Park, J E, Rettig, W J, Pfizenmaier, K, Moosmayer, D

“…Fibroblast activation protein (FAP) is a type II membrane protein expressed on tumor stroma fibroblasts in more than 90% of all carcinomas. FAP serves as a…”
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Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells by Pfizenmaier, K, Scheurich, P, Schluter, C, Kronke, M

“…Tumor necrosis factor-alpha (TNF-alpha) exerts multiple biologic activities, which include such diverse effects as direct tumoricidal activity and stimulation…”
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Tumor necrosis factors in 1998 by Wajant, H, Pfeffer, K, Pfizenmaier, K, Scheurich, P

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