Search Results - "Pfister, Thomas D."

ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses by Jossé, Rozenn, Martin, Scott E, Guha, Rajarshi, Ormanoglu, Pinar, Pfister, Thomas D, Reaper, Philip M, Barnes, Christopher S, Jones, Julie, Charlton, Peter, Pollard, John R, Morris, Joel, Doroshow, James H, Pommier, Yves

“…Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1) inhibitors and potent anticancer drugs killing cancer cells by…”
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Enhancing Mn(II)-Binding and Manganese Peroxidase Activity in a Designed Cytochrome c Peroxidase through Fine-Tuning Secondary-Sphere Interactions by Hosseinzadeh, Parisa, Mirts, Evan N, Pfister, Thomas D, Gao, Yi-Gui, Mayne, Christopher, Robinson, Howard, Tajkhorshid, Emad, Lu, Yi

“…Noncovalent second-shell interactions are important in controlling metal-binding affinity and activity in metalloenzymes, but fine-tuning these interactions in…”
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Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity by Pfister, Thomas D, Reinhold, William C, Agama, Keli, Gupta, Shalu, Khin, Sonny A, Kinders, Robert J, Parchment, Ralph E, Tomaszewski, Joseph E, Doroshow, James H, Pommier, Yves

“…Topoisomerase I (Top1) is a proven target for cancer therapeutics, and the level of Top1 in tumors has been used as a biomarker for chemotherapeutic efficacy…”
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Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells by Navas, Tony, Pfister, Thomas D, Colantonio, Simona, Aziz, Amina, Dieckman, Lynda, Saul, Richard G, Kaczmarczyk, Jan, Borgel, Suzanne, Alcoser, Sergio Y, Hollingshead, Melinda G, Lee, Young H, Bottaro, Donald P, Hiltke, Tara, Whiteley, Gordon, Takebe, Naoko, Kinders, Robert J, Parchment, Ralph E, Tomaszewski, Joseph E, Doroshow, James H

“…The presence of cancer stem cells (CSCs) and the induction of epithelial-to-mesenchymal transition (EMT) in tumors are associated with tumor aggressiveness,…”
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Identifying the Elusive Sites of Tyrosyl Radicals in Cytochrome c Peroxidase: Implications for Oxidation of Substrates Bound at a Site Remote from the Heme by Miner, Kyle D, Pfister, Thomas D, Hosseinzadeh, Parisa, Karaduman, Nadime, Donald, Lynda J, Loewen, Peter C, Lu, Yi, Ivancich, Anabella

“…The location of the Trp radical and the catalytic function of the [Fe­(IV)O Trp191 •+] intermediate in cytochrome c peroxidase (CcP) are well-established;…”
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A Site-Selective Dual Anchoring Strategy for Artificial Metalloprotein Design by Carey, James R, Ma, Steven K, Pfister, Thomas D, Garner, Dewain K, Kim, Hyeon K, Abramite, Joseph A, Wang, Zhilin, Guo, Zijian, Lu, Yi

“…Introducing nonnative metal ions or metal-containing prosthetic groups into a protein can dramatically expand the repertoire of its functionalities and thus…”
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The Root Causes of Pharmacodynamic Assay Failure by Ferry-Galow, Katherine V., PhD, Makhlouf, Hala R., MD, PhD, Wilsker, Deborah F., PhD, Lawrence, Scott M, Pfister, Thomas D., PhD, Marrero, Allison M., PhD, Bigelow, Kristina M, Yutzy, William H, Ji, Jiuping J., PhD, Butcher, Donna O, Gouker, Brad A, Kummar, Shivaani, MD, Chen, Alice P., MD, Kinders, Robert J., PhD, Parchment, Ralph E., PhD, Doroshow, James H., MD

“…Robust pharmacodynamic assay results are valuable for informing go/no‐go decisions about continued development of new anti-cancer agents and for identifying…”
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Neutral Thiol as a Proximal Ligand to Ferrous Heme Iron: Implications for Heme Proteins That Lose Cysteine Thiolate Ligation on Reduction by Perera, Roshan, Sono, Masanori, Sigman, Jeffrey A., Pfister, Thomas D., Lu, Yi, Dawson, John H.

“…Cysteine plays a key role as a metal ligand in metalloproteins. In all well-recognized cases, however, it is the anionic cysteinate that coordinates. Several…”
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Development and validation of an immunoassay for quantification of topoisomerase I in solid tumor tissues by Pfister, Thomas D, Hollingshead, Melinda, Kinders, Robert J, Zhang, Yiping, Evrard, Yvonne A, Ji, Jiuping, Khin, Sonny A, Borgel, Suzanne, Stotler, Howard, Carter, John, Divelbiss, Raymond, Kummar, Shivaani, Pommier, Yves, Parchment, Ralph E, Tomaszewski, Joseph E, Doroshow, James H

“…Topoisomerase I (Top1) is a proven target for cancer therapeutics. Recent data from the Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS) trial…”
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Safety, immunologic and clinical activity of Durvalumab in combination with Olaparib or Cediranib in advanced leiomyosarcoma: Results of the DAPPER clinical trial by Salawu, Abdulazeez, Wang, Ben X, Han, Ming, Geady, Caryn, Heirali, Alya, Berman, Hal K, Pfister, Thomas D, Hernando-Calvo, Alberto, Al-Ezzi, Esmail Mutahar, Stayner, Lee-Anne, Gupta, Abha A, Ayodele, Olubukola, Lam, Bernard, Hansen, Aaron R, Spreafico, Anna, Bedard, Philippe L, Butler, Marcus O, Avery, Lisa, Coburn, Bryan, Haibe-Kains, Benjamin, Siu, Lillian L, Abdul Razak, Albiruni R

“…Non-inflamed (cold) tumors such as leiomyosarcoma (LMS) do not benefit from immune checkpoint blockade (ICB) monotherapy. Combining ICB with angiogenesis-, or…”
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119 Uncovering spatial biology of mouse tumor immune microenvironment using imaging mass cytometry by Raza, Qanber, Lim, Liang, Pfister, Thomas D, Loh, Christina

“…BackgroundAdvances in therapies targeting immuno-oncological processes that dictate tumor growth, metastasis, and immune response require comprehensive…”
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Pharmacodynamic Response of the MET/HGF Receptor to Small-Molecule Tyrosine Kinase Inhibitors Examined with Validated, Fit-for-Clinic Immunoassays by Srivastava, Apurva K, Hollingshead, Melinda G, Weiner, Jennifer, Navas, Tony, Evrard, Yvonne A, Khin, Sonny A, Ji, Jiuping Jay, Zhang, Yiping, Borgel, Suzanne, Pfister, Thomas D, Kinders, Robert J, Bottaro, Donald P, Linehan, W Marston, Tomaszewski, Joseph E, Doroshow, James H, Parchment, Ralph E

“…Rational development of targeted MET inhibitors for cancer treatment requires a quantitative understanding of target pharmacodynamics, including molecular…”
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Monitoring Drug-Induced γH2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells by Wang, Lihua H., Pfister, Thomas D., Parchment, Ralph E., Kummar, Shivaani, Rubinstein, Larry, Evrard, Yvonne A., Gutierrez, Martin E., Murgo, Anthony J., Tomaszewski, Joseph E., Doroshow, James H., Kinders, Robert J.

“…Purpose: Circulating tumor cells (CTC) in peripheral blood of patients potentially represent a fraction of solid tumor cells available for more frequent…”
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Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors by Kummar, Shivaani, Chen, Alice, Gutierrez, Martin, Pfister, Thomas D., Wang, Lihua, Redon, Christophe, Bonner, William M., Yutzy, William, Zhang, Yiping, Kinders, Robert J., Ji, Jiuping, Allen, Deborah, Covey, Joseph M., Eiseman, Julie L., Holleran, Julianne L., Beumer, Jan H., Rubinstein, Larry, Collins, Jerry, Tomaszewski, Joseph, Parchment, Ralph, Pommier, Yves, Doroshow, James H.

“…Purpose Indenoisoquinolines are non-camptothecin topoisomerase I (TopI) inhibitors that overcome the limitations of camptothecins: chemical instability and…”
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Engineering Novel Metalloproteins:  Design of Metal-Binding Sites into Native Protein Scaffolds by Lu, Yi, Berry, Steven M, Pfister, Thomas D

“…The protein design process can be divided into two steps: the design of overall scaffold and the design of active sites. Lu et al focus on the creation of…”
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Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron by REINHOLD, William C, MERGNY, Jean-Louis, HONGFANG LIU, RYAN, Michael, PFISTER, Thomas D, KINDERS, Robert, PARCHMENT, Ralph, DOROSHOW, James, WEINSTEIN, John N, POMMIER, Yves

“…Because topoisomerase 1 (TOP1) is critical for the relaxation of DNA supercoils and because it is the target for the anticancer activity of camptothecins, we…”
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Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations by Jensen, Niels Frank, Agama, Keli, Roy, Amit, Smith, David Hersi, Pfister, Thomas D, Rømer, Maria Unni, Zhang, Hong-Liang, Doroshow, James H, Knudsen, Birgitta R, Stenvang, Jan, Brünner, Nils, Pommier, Yves

“…DNA topoisomerase I (Top1) is a DNA unwinding protein and the specific target of the camptothecin class of chemotherapeutic drugs. One of these, irinotecan,…”
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Abstract 5544: Development of recombinant transcription factor proteins and antibodies for application in clinical immunoassays by Pfister, Thomas D., Dieckman, Lynda J., Kinders, Robert J., Book, Anne, Colantonio, Simona, Mutreja, Karun, Lawrence, Scott M., Aziz, Amina, Hiltke, Tara, Whiteley, Gordon, Parchment, Ralph E., Tomaszewski, Joseph E., Weinberg, Robert A., Doroshow, James H.

“…Abstract EMT/stem cell transcription factors have been implicated in the differentiation of epithelial cells into mesenchymal cells (epithelial-mesenchymal…”
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Monooxygenation of an aromatic ring by F43W/H64D/V68I myoglobin mutant and hydrogen peroxide. Myoglobin mutants as a model for P450 hydroxylation chemistry by Pfister, Thomas D, Ohki, Takahiro, Ueno, Takafumi, Hara, Isao, Adachi, Seiji, Makino, Yumiko, Ueyama, Norikazu, Lu, Yi, Watanabe, Yoshihito

“…Myoglobin (Mb) is used as a model system for other heme proteins and the reactions they catalyze. The latest novel function to be proposed for myoglobin is a…”
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Insect freeze tolerance: Roles of protein phosphatases and protein kinase A by Pfister, Thomas D., Storey, Kenneth B.

“…Freeze-tolerant larvae of the goldenrod gall fly, Eurosta solidaginis Fitch, show multiple metabolic adaptations for subzero survival including the autumn…”
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