Search Results - "Pfister, Stefan M"

Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management by Sturm, Dominik, Pfister, Stefan M, Jones, David T W

“…Gliomas are the most common CNS tumors in children and adolescents, and they show an extremely broad range of clinical behavior. The majority of pediatric…”
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The 2021 WHO Classification of Tumors of the Central Nervous System: a summary by Louis, David N, Perry, Arie, Wesseling, Pieter, Brat, Daniel J, Cree, Ian A, Figarella-Branger, Dominique, Hawkins, Cynthia, Ng, H K, Pfister, Stefan M, Reifenberger, Guido, Soffietti, Riccardo, von Deimling, Andreas, Ellison, David W

“…Abstract The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS), published in 2021, is the sixth version of the…”
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Medulloblastomics revisited: biological and clinical insights from thousands of patients by Hovestadt, Volker, Ayrault, Olivier, Swartling, Fredrik J., Robinson, Giles W., Pfister, Stefan M., Northcott, Paul A.

“…Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has recently been the focus of intensive molecular profiling efforts,…”
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EANO guidelines for the diagnosis and treatment of ependymal tumors by Rudà, Roberta, Reifenberger, Guido, Frappaz, Didier, Pfister, Stefan M, Laprie, Anne, Santarius, Thomas, Roth, Patrick, Tonn, Joerg Christian, Soffietti, Riccardo, Weller, Michael, Moyal, Elizabeth Cohen-Jonathan

“…Ependymal tumors are rare CNS tumors and may occur at any age, but their proportion among primary brain tumors is highest in children and young adults. Thus,…”
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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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RF_Purify: a novel tool for comprehensive analysis of tumor-purity in methylation array data based on random forest regression by Johann, Pascal David, Jäger, Natalie, Pfister, Stefan M, Sill, Martin

“…With the advent of array-based techniques to measure methylation levels in primary tumor samples, systematic investigations of methylomes have widely been…”
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus by Ramaswamy, Vijay, Remke, Marc, Bouffet, Eric, Bailey, Simon, Clifford, Steven C., Doz, Francois, Kool, Marcel, Dufour, Christelle, Vassal, Gilles, Milde, Till, Witt, Olaf, von Hoff, Katja, Pietsch, Torsten, Northcott, Paul A., Gajjar, Amar, Robinson, Giles W., Padovani, Laetitia, André, Nicolas, Massimino, Maura, Pizer, Barry, Packer, Roger, Rutkowski, Stefan, Pfister, Stefan M., Taylor, Michael D., Pomeroy, Scott L.

“…Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent…”
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Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking by Weischenfeldt, Joachim, Dubash, Taronish, Drainas, Alexandros P, Mardin, Balca R, Chen, Yuanyuan, Stütz, Adrian M, Waszak, Sebastian M, Bosco, Graziella, Halvorsen, Ann Rita, Raeder, Benjamin, Efthymiopoulos, Theocharis, Erkek, Serap, Siegl, Christine, Brenner, Hermann, Brustugun, Odd Terje, Dieter, Sebastian M, Northcott, Paul A, Petersen, Iver, Pfister, Stefan M, Schneider, Martin, Solberg, Steinar K, Thunissen, Erik, Weichert, Wilko, Zichner, Thomas, Thomas, Roman, Peifer, Martin, Helland, Aslaug, Ball, Claudia R, Jechlinger, Martin, Sotillo, Rocio, Glimm, Hanno, Korbel, Jan O

“…Hanno Glimm, Jan Korbel and colleagues present a computational framework called cis expression structural alteration mapping (CESAM), which they use to…”
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Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes by Sharma, Tanvi, Schwalbe, Edward C., Williamson, Daniel, Sill, Martin, Hovestadt, Volker, Mynarek, Martin, Rutkowski, Stefan, Robinson, Giles W., Gajjar, Amar, Cavalli, Florence, Ramaswamy, Vijay, Taylor, Michael D., Lindsey, Janet C., Hill, Rebecca M., Jäger, Natalie, Korshunov, Andrey, Hicks, Debbie, Bailey, Simon, Kool, Marcel, Chavez, Lukas, Northcott, Paul A., Pfister, Stefan M., Clifford, Steven C.

“…In 2012, an international consensus paper reported that medulloblastoma comprises four molecular subgroups (WNT, SHH, Group 3, and Group 4), each associated…”
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Maturation Block in Childhood Cancer by Behjati, Sam, Gilbertson, Richard J, Pfister, Stefan M

“…The key differences between tumors arising in children and those in adults stem from the cellular origin of cancer at different ages, with adult cancers…”
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Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data by Maros, Máté E., Capper, David, Jones, David T. W., Hovestadt, Volker, von Deimling, Andreas, Pfister, Stefan M., Benner, Axel, Zucknick, Manuela, Sill, Martin

“…DNA methylation data-based precision cancer diagnostics is emerging as the state of the art for molecular tumor classification. Standards for choosing…”
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Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells by Sarropoulos, Ioannis, Sepp, Mari, Frömel, Robert, Leiss, Kevin, Trost, Nils, Leushkin, Evgeny, Okonechnikov, Konstantin, Joshi, Piyush, Giere, Peter, Kutscher, Lena M, Cardoso-Moreira, Margarida, Pfister, Stefan M, Kaessmann, Henrik

“…Organ development is orchestrated by cell- and time-specific gene regulatory networks. In this study, we investigated the regulatory basis of mouse cerebellum…”
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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma by Pei, Yanxin, Liu, Kun-Wei, Wang, Jun, Garancher, Alexandra, Tao, Ran, Esparza, Lourdes A., Maier, Donna L., Udaka, Yoko T., Murad, Najiba, Morrissy, Sorana, Seker-Cin, Huriye, Brabetz, Sebastian, Qi, Lin, Kogiso, Mari, Schubert, Simone, Olson, James M., Cho, Yoon-Jae, Li, Xiao-Nan, Crawford, John R., Levy, Michael L., Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Wechsler-Reya, Robert J.

“…Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Despite aggressive therapy, many patients succumb to the disease, and survivors experience…”
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K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas by Khuong-Quang, Dong-Anh, Buczkowicz, Pawel, Rakopoulos, Patricia, Liu, Xiao-Yang, Fontebasso, Adam M., Bouffet, Eric, Bartels, Ute, Albrecht, Steffen, Schwartzentruber, Jeremy, Letourneau, Louis, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Bourret, Genevieve, Lepage, Pierre, Fleming, Adam, Lichter, Peter, Kool, Marcel, von Deimling, Andreas, Sturm, Dominik, Korshunov, Andrey, Faury, Damien, Jones, David T., Majewski, Jacek, Pfister, Stefan M., Jabado, Nada, Hawkins, Cynthia

“…Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated…”
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Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations by Rausch, Tobias, Jones, David T.W., Zapatka, Marc, Stütz, Adrian M., Zichner, Thomas, Weischenfeldt, Joachim, Jäger, Natalie, Remke, Marc, Shih, David, Northcott, Paul A., Pfaff, Elke, Tica, Jelena, Wang, Qi, Massimi, Luca, Witt, Hendrik, Bender, Sebastian, Pleier, Sabrina, Cin, Huriye, Hawkins, Cynthia, Beck, Christian, von Deimling, Andreas, Hans, Volkmar, Brors, Benedikt, Eils, Roland, Scheurlen, Wolfram, Blake, Jonathon, Benes, Vladimir, Kulozik, Andreas E., Witt, Olaf, Martin, Dianna, Zhang, Cindy, Porat, Rinnat, Merino, Diana M., Wasserman, Jonathan, Jabado, Nada, Fontebasso, Adam, Bullinger, Lars, Rücker, Frank G., Döhner, Konstanze, Döhner, Hartmut, Koster, Jan, Molenaar, Jan J., Versteeg, Rogier, Kool, Marcel, Tabori, Uri, Malkin, David, Korshunov, Andrey, Taylor, Michael D., Lichter, Peter, Pfister, Stefan M., Korbel, Jan O.

“…Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving…”
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BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1 by Tönjes, Martje, Barbus, Sebastian, Park, Yoon Jung, Wang, Wei, Schlotter, Magdalena, Lindroth, Anders M, Pleier, Sabrina V, Bai, Alfa H C, Karra, Daniela, Piro, Rosario M, Felsberg, Jörg, Addington, Adele, Lemke, Dieter, Weibrecht, Irene, Hovestadt, Volker, Rolli, Claudio G, Campos, Benito, Turcan, Sevin, Sturm, Dominik, Witt, Hendrik, Chan, Timothy A, Herold-Mende, Christel, Kemkemer, Ralf, König, Rainer, Schmidt, Kathrin, Hull, William-Edmund, Pfister, Stefan M, Jugold, Manfred, Hutson, Susan M, Plass, Christoph, Okun, Jürgen G, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard

“…Branched-chain amino acid transaminase 1, the enzyme that initiates the catabolism of branched-chain amino acids, is involved in glioma pathogenesis, making it…”
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Molecular neuro-oncology in clinical practice: a new horizon by Weller, Michael, Prof, Pfister, Stefan M, MD, Wick, Wolfgang, Prof, Hegi, Monika E, PhD, Reifenberger, Guido, Prof, Stupp, Roger, Prof

“…Summary Primary brain tumours are heterogeneous in histology, genetics, and outcome. Although WHO's classification of tumours of the CNS has greatly helped to…”
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Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas by Appay, Romain, Fina, Frédéric, Macagno, Nicolas, Padovani, Laëtitia, Colin, Carole, Barets, Doriane, Ordioni, Joanna, Scavarda, Didier, Giangaspero, Felice, Badiali, Manuela, Korshunov, Andrey, M. Pfister, Stefan, T.W. Jones, David, Figarella-Branger, Dominique

“…Pilocytic astrocytomas represent the most common glioma subtype in young patients and account for 5.4% of all gliomas. They are characterized by alterations in…”
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Pediatric high-grade glioma: biologically and clinically in need of new thinking by Jones, Chris, Karajannis, Matthias A, Jones, David T W, Kieran, Mark W, Monje, Michelle, Baker, Suzanne J, Becher, Oren J, Cho, Yoon-Jae, Gupta, Nalin, Hawkins, Cynthia, Hargrave, Darren, Haas-Kogan, Daphne A, Jabado, Nada, Li, Xiao-Nan, Mueller, Sabine, Nicolaides, Theo, Packer, Roger J, Persson, Anders I, Phillips, Joanna J, Simonds, Erin F, Stafford, James M, Tang, Yujie, Pfister, Stefan M, Weiss, William A

“…High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed…”
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Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors by Wegert, Jenny, Ishaque, Naveed, Vardapour, Romina, Geörg, Christina, Gu, Zuguang, Bieg, Matthias, Ziegler, Barbara, Bausenwein, Sabrina, Nourkami, Nasenien, Ludwig, Nicole, Keller, Andreas, Grimm, Clemens, Kneitz, Susanne, Williams, Richard D., Chagtai, Tas, Pritchard-Jones, Kathy, van Sluis, Peter, Volckmann, Richard, Koster, Jan, Versteeg, Rogier, Acha, Tomas, O’Sullivan, Maureen J., Bode, Peter K., Niggli, Felix, Tytgat, Godelieve A., van Tinteren, Harm, van den Heuvel-Eibrink, Marry M., Meese, Eckart, Vokuhl, Christian, Leuschner, Ivo, Graf, Norbert, Eils, Roland, Pfister, Stefan M., Kool, Marcel, Gessler, Manfred

“…Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor…”
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