Search Results - "Pfefferle, Adam"

Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies by Hanker, Ariella B., Pfefferle, Adam D., Balko, Justin M., Kuba, María Gabriela, Young, Christian D., Sánchez, Violeta, Sutton, Cammie R., Cheng, Hailing, Perou, Charles M., Zhao, Jean J., Cook, Rebecca S., Arteaga, Carlos L.

“…Human epidermal growth factor receptor 2 (HER2 ; ERBB2) amplification and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA)…”
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Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells by Rädler, Patrick D., Wehde, Barbara L., Triplett, Aleata A., Shrestha, Hridaya, Shepherd, Jonathan H., Pfefferle, Adam D., Rui, Hallgeir, Cardiff, Robert D., Perou, Charles M., Wagner, Kay-Uwe

“…Claudin-low breast cancer represents an aggressive molecular subtype that is comprised of mostly triple-negative mammary tumor cells that possess stem…”
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LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma by Liu, Wenjin, Monahan, Kimberly B., Pfefferle, Adam D., Shimamura, Takeshi, Sorrentino, Jessica, Chan, Keefe T., Roadcap, David W., Ollila, David W., Thomas, Nancy E., Castrillon, Diego H., Miller, C. Ryan, Perou, Charles M., Wong, Kwok-Kin, Bear, James E., Sharpless, Norman E.

“…Germline mutations in LKB1 (STK11) are associated with the Peutz-Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1…”
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Oncogenic PI3K Mutations Lead to NF-κB―Dependent Cytokine Expression following Growth Factor Deprivation by HUTTI, Jessica E, PFEFFERLE, Adam D, RUSSELL, Sean C, SIRCAR, Mayukh, PEROU, Charles M, BALDWIN, Albert S

“…The phosphoinositide 3-kinase (PI3K) pathway is one of the most commonly misregulated signaling pathways in human cancers, but its impact on the tumor…”
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Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer by Rashid, Narmeen S., Boyd, David C., Olex, Amy L., Grible, Jacqueline M., Duong, Alex K., Alzubi, Mohammad A., Altman, Julia E., Leftwich, Tess J., Valentine, Aaron D., Hairr, Nicole S., Zboril, Emily K., Smith, Timothy M., Pfefferle, Adam D., Dozmorov, Mikhail G., Harrell, J. Chuck

“…The goals of this study were to identify transcriptomic changes that arise in basal-like breast cancer cells during the development of resistance to epidermal…”
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Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models by ROBERT, Patrick J, USARY, Jerry E, ZAMBONI, William C, JOHNSON, Gary L, PEROU, Charles M, SHARPLESS, Norman E, DARR, David B, DILLON, Patrick M, PFEFFERLE, Adam D, WHITTLE, Martin C, DUNCAN, James S, JOHNSON, Soren M, COMBEST, Austin J, JIAN JIN

“…Anticancer drug development is inefficient, but genetically engineered murine models (GEMM) and orthotopic, syngeneic transplants (OST) of cancer may offer…”
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Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts by Pfefferle, Adam D, Herschkowitz, Jason I, Usary, Jerry, Chuck Harrell, Joshua, Spike, Benjamin T, Adams, Jessica R, Torres-Arzayus, Maria I, Brown, Myles, Egan, Sean E, Wahl, Geoffrey M, Rosen, Jeffrey M, Perou, Charles M

“…BACKGROUND: Human breast cancer is a heterogeneous disease consisting of multiple molecular subtypes. Genetically engineered mouse models are a useful resource…”
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Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy by Pfefferle, Adam D., Spike, Benjamin T., Wahl, Geoff M., Perou, Charles M.

“…Mammary gland morphology and physiology are supported by an underlying cellular differentiation hierarchy. Molecular features associated with particular cell…”
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Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver by Wallace, Marsha D, Pfefferle, Adam D, Shen, Lishuang, McNairn, Adrian J, Cerami, Ethan G, Fallon, Barbara L, Rinaldi, Vera D, Southard, Teresa L, Perou, Charles M, Schimenti, John C

“…Identifying genomic alterations driving breast cancer is complicated by tumor diversity and genetic heterogeneity. Relevant mouse models are powerful for…”
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A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer by Hollern, Daniel P., Contreras, Cristina M., Dance-Barnes, Stephanie, Silva, Grace O., Pfefferle, Adam D., Xiong, Jessie, Darr, David B., Usary, Jerry, Mott, Kevin R., Perou, Charles M.

“…Purpose and methods In human basal-like breast cancer, mutations and deletions in TP53 and BRCA1 are frequent oncogenic events. Thus, we interbred mice…”
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The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor by Pfefferle, Adam D, Darr, David B, Calhoun, Benjamin C, Mott, Kevin R, Rosen, Jeffrey M, Perou, Charles M

“…The Wnt gene family encodes an evolutionarily conserved group of proteins that regulate cell growth, differentiation and stem cell self-renewal. Aberrant Wnt…”
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Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers by Pfefferle, Adam D, Agrawal, Yash N, Koboldt, Daniel C, Kanchi, Krishna L, Herschkowitz, Jason I, Mardis, Elaine R, Rosen, Jeffrey M, Perou, Charles M

“…Targeted therapies against basal-like breast tumors, which are typically 'triple-negative breast cancers (TNBCs)', remain an important unmet clinical need…”
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Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis by Harrell, J. Chuck, Pfefferle, Adam D., Zalles, Nicole, Prat, Aleix, Fan, Cheng, Khramtsov, Andrey, Olopade, Olufunmilayo I., Troester, Melissa A., Dudley, Andrew C., Perou, Charles M.

“…The vasculature serves as the main conduit for breast tumor metastases and is a target of therapeutics in many tumor types. In this study, we aimed to…”
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Cell-cycle inhibition and immune microenvironment in breast cancer treated with ribociclib and letrozole or chemotherapy by Pascual, Tomás, Fernandez-Martinez, Aranzazu, Agrawal, Yash, Pfefferle, Adam D., Chic, Nuria, Brasó-Maristany, Fara, Gonzàlez-Farré, Blanca, Paré, Laia, Villacampa, Guillermo, Saura, Cristina, Hernando, Cristina, Muñoz, Montserrat, Galván, Patricia, Gonzàlez-Farré, Xavier, Oliveira, Mafalda, Gil-Gil, Miguel, Ciruelos, Eva, Villagrasa, Patricia, Gavilá, Joaquín, Prat, Aleix, Perou, Charles M.

“…In this study, we performed genomic analyses of cell cycle and tumor microenvironment changes during and after ribociclib and letrozole or chemotherapy in the…”
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A pipeline to determine RT-QPCR control genes for evolutionary studies: application to primate gene expression across multiple tissues by Fedrigo, Olivier, Warner, Lisa R, Pfefferle, Adam D, Babbitt, Courtney C, Cruz-Gordillo, Peter, Wray, Gregory A

“…Because many species-specific phenotypic differences are assumed to be caused by differential regulation of gene expression, many recent investigations have…”
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Conditional Loss of ErbB3 Delays Mammary Gland Hyperplasia Induced by Mutant PIK3CA without Affecting Mammary Tumor Latency, Gene Expression, or Signaling by YOUNG, Christian D, PFEFFERLE, Adam D, COOK, Rebecca S, ARTEAGA, Carlos L, OWENS, Philip, KUBA, María G, REXER, Brent N, BALKO, Justin M, SANCHEZ, Violeta, HAILING CHENG, PEROU, Charles M, ZHAO, Jean J

“…Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), have been shown to transform mammary epithelial cells…”
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Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes by Usary, Jerry, Darr, David Brian, Pfefferle, Adam D, Perou, Charles M

“…Advances in the screening of new therapeutic options have significantly reduced the breast cancer death rate over the last decade. Despite these advances,…”
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Both noncoding and protein-coding RNAs contribute to gene expression evolution in the primate brain by Babbitt, Courtney C, Fedrigo, Olivier, Pfefferle, Adam D, Boyle, Alan P, Horvath, Julie E, Furey, Terrence S, Wray, Gregory A

“…Despite striking differences in cognition and behavior between humans and our closest primate relatives, several studies have found little evidence for…”
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c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression by Cantrell, Michael A, Ebelt, Nancy D, Pfefferle, Adam D, Perou, Charles M, Van Den Berg, Carla Lynn

“…Breast cancer is a heterogeneous disease with several subtypes carrying unique prognoses. Patients with differentiated luminal tumors experience better…”
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A potential role for glucose transporters in the evolution of human brain size by Fedrigo, Olivier, Pfefferle, Adam D, Babbitt, Courtney C, Haygood, Ralph, Wall, Christine E, Wray, Gregory A

“…Differences in cognitive abilities and the relatively large brain are among the most striking differences between humans and their closest primate relatives…”
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