Search Results - "Pfau, J"

Bridging barriers: a comparative look at the blood-brain barrier across organisms by O'Brown, Natasha M, Pfau, Sarah J, Gu, Chenghua

“…The blood-brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment…”
Get full text

Chromosomal instability and aneuploidy in cancer: from yeast to man by Pfau, Sarah J, Amon, Angelika

“…Aneuploidy is frequently associated with disease and developmental abnormalities. It is also a key characteristic of cancer. Several model systems have been…”
Get full text

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo by Pfau, Sarah J, Silberman, Rebecca E, Knouse, Kristin A, Amon, Angelika

“…Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has long been hypothesized to promote tumorigenesis. Here we evaluate…”
Get full text

let-7 Overexpression Leads to an Increased Fraction of Cells in G2/M, Direct Down-regulation of Cdc34, and Stabilization of Wee1 Kinase in Primary Fibroblasts by Legesse-Miller, Aster, Elemento, Olivier, Pfau, Sarah J., Forman, Joshua J., Tavazoie, Saeed, Coller, Hilary A.

“…microRNAs play a critically important role in a wide array of biological processes including those implicated in cancer, neuro-degenerative and metabolic…”
Get full text

Silica accelerated systemic autoimmune disease in lupus‐prone New Zealand mixed mice by BROWN, J. M., ARCHER, A. J., PFAU, J. C., HOLIAN, A.

“…Summary The genetic backgrounds of lupus‐prone murine models are a valuable resource for studying the influence of environmental exposure on autoimmune…”
Get full text

Aneuploidy Drives Genomic Instability in Yeast by Sheltzer, Jason M., Blank, Heidi M., Pfau, Sarah J., Tange, Yoshie, George, Benson M., Humpton, Timothy J., Brito, Ilana L., Hiraoka, Yasushi, Niwa, Osami, Amon, Angelika

“…Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by…”
Get full text

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells by Pfau, Sarah J., Langen, Urs H., Fisher, Theodore M., Prakash, Indumathi, Nagpurwala, Faheem, Lozoya, Ricardo A., Lee, Wei-Chung Allen, Wu, Zhuhao, Gu, Chenghua

“…The blood–brain barrier (BBB) protects the brain and maintains neuronal homeostasis. BBB properties can vary between brain regions to support regional…”
Get full text

Bounding Analysis of Drinking Water Health Risks from a Spill of Hydraulic Fracturing Flowback Water by Rish, William R., Pfau, Edward J.

“…A bounding risk assessment is presented that evaluates possible human health risk from a hypothetical scenario involving a 10,000‐gallon release of flowback…”
Get full text

Assessment of Autoimmune Responses Associated with Asbestos Exposure in Libby, Montana, USA by Pfau, Jean C., Sentissi, Jami J., Weller, Greg, Putnam, Elizabeth A.

“…Systemic autoimmune responses are associated with certain environmental exposures, including crystalline particles such as silica. Positive antinuclear…”
Get full text

Intraoperative Nerve Monitoring for Tarsal Tunnel Decompression: A Surgical Technique to Improve Outcomes by Still, Gregory P., Pfau, Zeno J., Cordoba, Aniela, Jupiter, Daniel C.

“…The aim of the current study was to evaluate the effectiveness of intraoperative neuromonitoring (INM) as an adjunct in performing tarsal tunnel decompression…”
Get full text

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis by Tang, Yun-Chi, Yuwen, Hui, Wang, Kaiying, Bruno, Peter M, Bullock, Kevin, Deik, Amy, Santaguida, Stefano, Trakala, Marianna, Pfau, Sarah J, Zhong, Na, Huang, Tao, Wang, Lan, Clish, Clary B, Hemann, Michael T, Amon, Angelika

“…Aneuploidy, a hallmark of cancer cells, poses an appealing opportunity for cancer treatment and prevention strategies. Using a cell-based screen to identify…”
Get full text

Electrochemical Stability of Thin-Film Platinum as Suitable Material for Neural Stimulation Electrodes by Pfau, J., Ganatra, D., Weltin, A., Urban, G., Kieninger, J., Stieglitz, T.

“…Only thin-film technology can satisfy the requirements of high spatial selectivity at high-channel-count electrode array designs by simultaneously good…”
Get full text

In Situ Measurement of Stimulus Induced pH Changes Using ThinFilm Embedded IrOx pH Electrodes by Pfau, J., Leal Ordonez, J. A., Stieglitz, T.

“…The high complexity of the biological response to implanted materials builds a serious barrier against implanted recording and stimulation electrode arrays to…”
Get full text

CoGe surface oxidation studied using X-ray photoelectron spectroscopy by Pfau, Andrew J., Trey Diulus, J., He, Shidong, Albuquerque, Gustavo H., Stickle, William F., Herman, Gregory S.

“…•CoGe alloy films were deposited by sputter deposition.•After annealing the films in high vacuum the β-Co5Ge3 phase was formed.•XPS results indicate that the…”
Get full text

Silica-exposed mice generate autoantibodies to apoptotic cells by Pfau, Jean C., Brown, Jared M., Holian, Andrij

“…Silica exposure has been associated with development of autoantibodies and systemic autoimmune disease, but mechanisms leading to these events are unknown…”
Get full text

Internalization of Libby Amphibole Asbestos and Induction of Oxidative Stress in Murine Macrophages by Blake, David J., Bolin, Celeste M., Cox, David P., Cardozo-Pelaez, Fernando, Pfau, Jean C.

“…The community members of Libby, MT, have experienced significant asbestos exposure and developed numerous asbestos-related diseases including fibrosis and lung…”
Get full text

A System to Study Aneuploidy In Vivo by Pfau, Sarah J, Amon, Angelika

“…Aneuploidy, an imbalanced chromosome number, is associated with both cancer and developmental disorders such as Down syndrome (DS). To determine how aneuploidy…”
Get full text

Vibrio cholerae H-NS Silences Virulence Gene Expression at Multiple Steps in the ToxR Regulatory Cascade by Nye, M B, Pfau, J D, Skorupski, K, Taylor, R K

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland ( Squalus acanthias) by Neuman, Rugina I, van Kalmthout, Juliette A M, Pfau, Daniel J, Menendez, Dhariyat M, Young, Lawrence H, Forrest, Jr, John N

“…The production of endogenous adenosine during secretagogue stimulation of CFTR leads to feedback inhibition limiting further chloride secretion in the rectal…”
Get more information

836 Calibration performance of deep neural networks for image classification declines on real-world, versus curated, test sets by Young, A.T., Pfau, J., Keiser, M.J., Wei, M.

Get full text