Search Results - "Pfarr, K."

Filariasis in Africa—treatment challenges and prospects by Hoerauf, A., Pfarr, K., Mand, S., Debrah, A.Y., Specht, S.

“…Lymphatic filariasis (LF) and onchocerciasis are parasitic nematode infections that are responsible for a major disease burden in the African continent…”
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Filariasis and lymphoedema by PFARR, K.M, DEBRAH, A.Y, SPECHT, S, HOERAUF, A

“…Among the causes of lymphoedema (LE), secondary LE due to filariasis is the most prevalent. It affects only a minority of the 120 million people infected with…”
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Antibiotics which target the Wolbachia endosymbionts of filarial parasites: a new strategy for control of filariasis and amelioration of pathology by Pfarr, K M, Hoerauf, A M

“…Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has…”
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A Randomized, Double-Blind Clinical Trial of a 3-Week Course of Doxycycline plus Albendazole and Ivermectin for the Treatment of Wuchereria bancrofti Infection by Turner, Joseph D., Mand, Sabine, Debrah, Alexander Yaw, Muehlfeld, Johannes, Pfarr, Kenneth, McGarry, Helen F., Adjei, Ohene, Taylor, Mark J., Hoerauf, Achim

“…Background. Eight- and 6-week courses of doxycycline are superior to standard treatment of bancroftian filariasis. Standard treatment (albendazole plus…”
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The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia by Pfarr, K M, Heider, U, Schmetz, C, Büttner, D W, Hoerauf, A

“…Wolbachia, a genus of endosymbiotic bacteria of filarial worms, represent novel targets for anti-filarial therapy. The efficacy of compounds against Wolbachia…”
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P485 THE RATIO OF ASCITES CALPROTECTIN TO TOTAL PROTEIN IS A DIAGNOSTIC AND PROGNOSTIC MARKER FOR SPONTANEOUS BACTERIAL PERITONITIS IN LIVER CIRRHOSIS by Lutz, P, Pfarr, K, Nischalke, H.-D, Krämer, B, Goeser, F, Nattermann, J, Sauerbruch, T, Hoerauf, A, Strassburg, C.P, Spengler, U

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Antibiotic Chemotherapy of Onchocerciasis: In a Bovine Model, Killing of Adult Parasites Requires a Sustained Depletion of Endosymbiotic Bacteria (Wolbachia Species) by Gilbert, Jeffrey, Nfon, Charles K., Makepeace, Benjamin L., Njongmeta, Leo M., Hastings, Ian M., Pfarr, Kenneth M., Renz, Alfons, Tanya, Vincent N., Trees, Alexander J.

“…Development of a drug lethal to adult Onchocerca volvulus (i.e., macrofilaricide) is a research priority for the control of human onchocerciasis. Using bovine…”
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Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production by HOERAUF, Achim, MAND, Sabine, FISCHER, Kerstin, KRUPPA, Thomas, MARFO-DEBREKYEI, Yeboah, YAW DEBRAH, Alexander, PFARR, Kenneth M, ADJEI, Ohene, BÜTTNER, Dietrich W

“…Chemotherapy of onchocerciasis by doxycycline, which targets symbiotic Wolbachia endobacteria, has been shown to result in a long-term sterility of adult…”
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Nitric Oxide Synthase in Filariae: Demonstration of Nitric Oxide Production by Embryos in Brugia malayi and Acanthocheilonema viteae by Pfarr, Kenneth M., Qazi, Sanjive, Fuhrman, Juliet A.

“…Pfarr, K. M., Qazi, S., and Fuhrman, J. A. 2001. Nitric oxide synthase in filariae: Demonstration of nitric oxide production by embryos in Brugia malayi and…”
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Brugia malayi: Localization of Nitric Oxide Synthase in a Lymphatic Filariid by Pfarr, Kenneth M, Fuhrman, Juliet A

“…Pfarr, K. M., and Fuhrman, J. A. 2000. Brugia malayi: Localization of nitric oxide synthase in a lymphatic filariid. Experimental Parasitology94, 92–98. Nitric…”
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Reduction in Levels of Plasma Vascular Endothelial Growth Factor-A and Improvement in Hydrocele Patients by Targeting Endosymbiotic Wolbachia sp. in Wuchereria bancrofti with Doxycycline by Debrah, Alexander Y, Mand, Sabine, Marfo-Debrekyei, Yeboah, Batsa, Linda, Pfarr, Kenneth, Lawson, Bernard, Taylor, Mark, Adjei, Ohene, Hoerauf, Achim

“…The treatment for hydrocele is expensive, invasive surgery-hydrocelectomy. A drug that could prevent or improve this condition could replace or supplement…”
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RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype by Pfarr, Kenneth, Heider, Ulrike, Hoerauf, Achim

“…In this report, the actin gene from the rodent filaria Litomosoides sigmodontis was successfully knocked down by RNA interference (RNAi). By establishing…”
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Macrofilaricidal Activity and Amelioration of Lymphatic Pathology in Bancroftian Filariasis after 3 Weeks of Doxycycline Followed by Single-Dose Diethylcarbamazine by Mand, Sabine, Pfarr, Kenneth, Sahoo, Prakash K, Satapathy, Ashok K, Specht, Sabine, Klarmann, Ute, Debrah, Alexander Y, Ravindran, Balachandran, Hoerauf, Achim

“…In a placebo controlled trial, the effects of 21- and 10-day doxycycline treatments (200 mg/day) followed by single dose diethylcarbamazine (administered 4…”
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Filariasis in Africa—treatment challenges and prospects : Neglected and emerging diseases in sub-Saharan Africa by HOERAUF, A, PFARR, K, MAND, S, DEBRAH, A. Y, SPECHT, S

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Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis by Debrah, Alexander Yaw, Mand, Sabine, Toliat, Mohammad Reza, Marfo-Debrekyei, Yeboah, Batsa, Linda, Nürnberg, Peter, Lawson, Bernard, Adjei, Ohene, Hoerauf, Achim, Pfarr, Kenneth

“…Hydrocele is a build-up of fluid in the scrotal regions of a proportion of men infected with the filarial nematode Wuchereria bancrofti. Vascular endothelial…”
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The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicine by Pfarr, Kenneth, Hoerauf, Achim

“…Filarial nematodes contain endosymbiotic bacteria of the genus Wolbachia. As described in the April 2005 issue of PLoS Biology, Foster et al. have sequenced…”
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Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis by Pfarr, Kenneth M, Fischer, Kerstin, Hoerauf, Achim

“…To examine the role that lipopolysaccharide (LPS)-like molecules from the filarial intracellular endobacteria Wolbachia might play in the development of…”
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A niche for Wolbachia by Pfarr, Kenneth M, Hoerauf, Achim

“…Wolbachia are endosymbionts of arthropods and filarial nematodes. Arthropods infected with these endobacteria display altered reproductive phenotypes,…”
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Characterisation of age and polarity at onset in bipolar disorder by Vreeker, Annabel, McQuillin, Andrew, Stahl, Eli A., Bigdeli, Tim B., Stein, Frederike, Pelin, Helena, Adams, Mark J., Adolfsson, Rolf, Adorjan, Kristina, Aminoff, Sofie R., Anderson-Schmidt, Heike, Andreassen, Ole A., Balaban, Ceylan, Bass, Nicholas, Baune, Bernhard T., Bengesser, Susanne, Berrettini, Wade H, Boks, Marco P., Bromet, Evelyn J., Brosch, Katharina, Budde, Monika, Cervantes, Pablo, Chillotti, Catina, Cichon, Sven, Clark, Scott R., Comes, Ashley L., Corvin, Aiden, Croarkin, Paul E., Degenhardt, Franziska, DePaulo, J. Raymond, Eissa, Mariam Al, Elvsåshagen, Torbjørn, Etain, Bruno, Fanous, Ayman H., Fellendorf, Frederike, Fiorentino, Alessia, Frye, Mark A., Fullerton, Janice M., Gill, Michael, Gordon-Smith, Katherine, Guzman-Parra, Jose, Hasler, Roland, Heilbronner, Maria, Jamain, Stephane, Jones, Ian, Kelsoe, John R., Kennedy, James L., Kircher, Tilo, Kirov, George, Kranz, Thorsten M., Lagerberg, Trine Vik, Landen, Mikael, Li, Qingqin S., Malaspina, Dolores, Manchia, Mirko, Mayoral, Fermin, McIntosh, Andrew M., Medeiros, Helena, Melle, Ingrid, Milanova, Vihra, Nöthen, Markus M., Opel, Nils, Ortiz, Abigail, Owen, Michael J., Pålsson, Erik, Pato, Carlos, Pato, Michele T., Pawlak, Joanna, Pfarr, Julia-Katharina, Pisanu, Claudia, Rapaport, Mark H, Reich-Erkelenz, Daniela, Reininghaus, Eva, Repple, Jonathan, Richard-Lepouriel, Hélène, Roberts, Gloria, Schmitt, Simon, Schofield, Peter R., Schubert, K. Oliver, Schulte, Eva C., Severino, Giovanni, Sharp, Sally, Slaney, Claire, Sobell, Janet L., Squassina, Alessio, Stopkova, Pavla, Turecki, Gustavo, Twarowska-Hauser, Joanna, Veldic, Marin, Vieta, Eduard, Vincent, John B., Xu, Wei, Zai, Clement C., Di Florio, Arianna, Smoller, Jordan W., Biernacka, Joanna M., Alda, Martin, Falkai, Peter, Schulze, Thomas G., Ophoff, Roel A.

“…Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease…”
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Endo16, a Large Multidomain Protein Found on the Surface and ECM of Endodermal Cells during Sea Urchin Gastrulation, Binds Calcium by Soltysik-Española, Margaret, Klinzing, David C., Pfarr, Kenneth, Burke, Robert D., Ernst, Susan G.

“…Endo16 encodes a developmentally regulated protein restricted to cells participating in the formation of the archenteron during sea urchin gastrulation and to…”
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