Search Results - "Pfarr, K M"
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The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia
Published in Parasitology (01-04-2008)“…Wolbachia, a genus of endosymbiotic bacteria of filarial worms, represent novel targets for anti-filarial therapy. The efficacy of compounds against Wolbachia…”
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Filariasis and lymphoedema
Published in Parasite immunology (01-11-2009)“…Among the causes of lymphoedema (LE), secondary LE due to filariasis is the most prevalent. It affects only a minority of the 120 million people infected with…”
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Antibiotics which target the Wolbachia endosymbionts of filarial parasites: a new strategy for control of filariasis and amelioration of pathology
Published in Mini reviews in medicinal chemistry (01-02-2006)“…Wolbachia endosymbionts of filariae are targets for the development of new antifilarial chemotherapy. Doxycycline to deplete Wolbachia from the worm has…”
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Brugia malayi: Localization of Nitric Oxide Synthase in a Lymphatic Filariid
Published in Experimental parasitology (01-02-2000)“…Pfarr, K. M., and Fuhrman, J. A. 2000. Brugia malayi: Localization of nitric oxide synthase in a lymphatic filariid. Experimental Parasitology94, 92–98. Nitric…”
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Nitric Oxide Synthase in Filariae: Demonstration of Nitric Oxide Production by Embryos in Brugia malayi and Acanthocheilonema viteae
Published in Experimental parasitology (01-04-2001)“…Pfarr, K. M., Qazi, S., and Fuhrman, J. A. 2001. Nitric oxide synthase in filariae: Demonstration of nitric oxide production by embryos in Brugia malayi and…”
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Antibiotic Chemotherapy of Onchocerciasis: In a Bovine Model, Killing of Adult Parasites Requires a Sustained Depletion of Endosymbiotic Bacteria (Wolbachia Species)
Published in The Journal of infectious diseases (15-10-2005)“…Development of a drug lethal to adult Onchocerca volvulus (i.e., macrofilaricide) is a research priority for the control of human onchocerciasis. Using bovine…”
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Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production
Published in Medical microbiology and immunology (01-11-2003)“…Chemotherapy of onchocerciasis by doxycycline, which targets symbiotic Wolbachia endobacteria, has been shown to result in a long-term sterility of adult…”
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A niche for Wolbachia
Published in Trends in parasitology (01-01-2007)“…Wolbachia are endosymbionts of arthropods and filarial nematodes. Arthropods infected with these endobacteria display altered reproductive phenotypes,…”
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Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis
Published in Medical Microbiology and Immunology (01-02-2003)“…To examine the role that lipopolysaccharide (LPS)-like molecules from the filarial intracellular endobacteria Wolbachia might play in the development of…”
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