Search Results - "Pfannenstiel, Lukas W."

Tumor-derived exosomes induce CD8 + T cell suppressors by Maybruck, Brian T, Pfannenstiel, Lukas W, Diaz-Montero, Marcela, Gastman, Brian R

“…The suppressive nature of immune cells in the tumor microenvironment plays a major role in regulating anti-tumor immune responses. Our previous work…”
Get full text

Combination PD-1 blockade and irradiation of brain metastasis induces an effective abscopal effect in melanoma by Pfannenstiel, Lukas W., McNeilly, Corey, Xiang, Chaomei, Kang, Kai, Diaz-Montero, Claudia Marcella, Yu, Jennifer S., Gastman, Brian R.

“…Nearly half of melanoma patients develop brain metastases during the course of their disease. Despite advances in both localized radiation and systemic…”
Get full text

Inhibition of Mcl-1 Promotes Senescence in Cancer Cells: Implications for Preventing Tumor Growth and Chemotherapy Resistance by Bolesta, Elzbieta, Pfannenstiel, Lukas W., Demelash, Abeba, Lesniewski, Mathew L., Tobin, Megan, Schlanger, Simon E., Nallar, Shreeram C., Papadimitriou, John C., Kalvakolanu, Dhan V., Gastman, Brian R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Autologous human preclinical modeling of melanoma interpatient clinical responses to immunotherapeutics by Phoon, Yee Peng, Lopes, Jared E, Pfannenstiel, Lukas W, Marcela Diaz-Montero, Claudia, Tian, Ye F, Ernstoff, Marc S, Funchain, Pauline, Ko, Jennifer S, Winquist, Raymond, Losey, Heather C, Melenhorst, Jan Joseph, Gastman, Brian R

“…BackgroundDespite recent advances in immunotherapy, a substantial population of late-stage melanoma patients still fail to achieve sustained clinical benefit…”
Get full text

Immune-Checkpoint Blockade Opposes CD8 + T-cell Suppression in Human and Murine Cancer by Pfannenstiel, Lukas W, Diaz-Montero, C Marcela, Tian, Ye F, Scharpf, Joseph, Ko, Jennifer S, Gastman, Brian R

“…Immune-checkpoint blockade enhances antitumor responses against cancers. One cancer type that is sensitive to checkpoint blockade is squamous cell carcinoma of…”
Get more information

Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice by Pfannenstiel, Lukas W., Lam, Samuel S.K., Emens, Leisha A., Jaffee, Elizabeth M., Armstrong, Todd D.

“…Subclinical doses of Paclitaxel (PTX) given 1 day prior to a HER-2/ neu (neu)-targeted, granulocyte–macrophage colony stimulating factor (GM-CSF)-secreting…”
Get full text

Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response by Ercolini, Anne M, Ladle, Brian H, Manning, Elizabeth A, Pfannenstiel, Lukas W, Armstrong, Todd D, Machiels, Jean-Pascal H, Bieler, Joan G, Emens, Leisha A, Reilly, R Todd, Jaffee, Elizabeth M

“…A major barrier to successful antitumor vaccination is tolerance of high-avidity T cells specific to tumor antigens. In keeping with this notion, HER-2/neu…”
Get full text

Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain by Demelash, Abeba, Pfannenstiel, Lukas W., Tannenbaum, Charles S., Li, Xiaoxia, Kalady, Matthew F., DeVecchio, Jennifer, Gastman, Brian R.

“…Unlike other antiapoptotic Bcl-2 family members, Mcl-1 also mediates resistance to cancer therapy by uniquely inhibiting chemotherapy-induced senescence (CIS)…”
Get full text

Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence by Demelash, Abeba, Pfannenstiel, Lukas W, Liu, Li, Gastman, Brian R

“…Mcl-1, a Bcl-2 family member, is highly expressed in a variety of human cancers and is believed to enhance tumorigenic potential and chemotherapy resistance…”
Get full text

Mcl-1 and tumor cell persistence by Pfannenstiel, Lukas W, Gastman, Brian R

Get full text

Interleukin-7 Inhibits Tumor-Induced CD27-CD28- Suppressor T Cells: Implications for Cancer Immunotherapy by YUE ZHANG, PFANNENSTIEL, Lukas W, BOLESTA, Elzbieta, MONTES, Carolina L, XIAOYU ZHANG, CHAPOVAL, Andrei I, GARTENHAUS, Ronald B, STROME, Scott E, GASTMAN, Brian R

“…We have previously reported that many types of tumors can induce changes in human T cells that lead to the acquisition of suppressive function and phenotypic…”
Get full text

Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence by Demelash, Abeba, Pfannenstiel, Lukas W., Liu, Li, Gastman, Brian R.

Get full text

Raiding the pharmacy: genomic screening identifies known chemotherapies as negative regulators of MCL1 by Pfannenstiel, Lukas W, Demelash, Abeba, Gastman, Brian R

“…Despite multiple studies demonstrating the importance of the anti-apoptotic protein Mcl-1 in tumor cell survival and treatment resistance, a clinically…”
Get full text

Abstract P34: Tumor-Induced Suppressive CD8+ T Cells by Pfannenstiel, Lukas W, Maybruck, Brian T, Gastman, Brian R

Get full text

Mcl-1 expression influcences CD8+ anti-tumor immunity by Pfannenstiel, Lukas W, Gastman, Brian R

“…The recent clinical successes of immunotherapies such as anti-PD-1 and anti-CTLA-4 antibody blockade have re-invigorated the idea that the immune system has…”
Get full text

Abstract 1818: Developing an autologous humanized mouse model to assess responses to novel immunotherapeutics by Phoon, Yee Peng, Lopes, Jared E., Pfannenstiel, Lukas W., Diaz-Montero, C. Marcela, Tian, Ye F., Ernstoff, Marc S., Funchain, Pauline, Li, XiaoXia, Losey, Heather C., Winquist, Raymond J., Gastman, Brian R.

“…Abstract Introduction: The development and FDA approval of drugs targeting the PD-1/PD-L1 axis has greatly shifted the paradigm of immunotherapy and has…”
Get full text

Abstract P33: A Distinct Domain of Mcl1 Regulates Senescence Inhibition in Cancer by Demelash, Abeba, Pfannenstiel, Lukas W, Maybruck, Brian T, Schlanger, Simon E, Charles, Tannenbaum S, Gastman, Brian R

Get full text

Tumor-induced suppressive CD8+ T cells: implications for cancer immunotherapy by Pfannenstiel, Lukas W, Gastman, Brian R

“…The immune system has the potential to be a powerful tool to destroy tumors; however despite ample evidence of endogenous anti-tumor immune responses in many…”
Get full text

Targeting immune checkpoint pathways overcomes tumor-induced CD8+ T cell suppression by Pfannenstiel, Lukas W, Gastman, Brian R

“…The immune system has the potential to be a powerful tool to destroy tumors. However despite ample evidence of anti-tumor immune responses in many patients, as…”
Get full text

Harnessing the potential of radiation treatment of brain metastases to improve melanoma immunotherapy by McNeilly, Corey D, Pfannenstiel, Lukas W, Xiang, Chaomei, Yu, Jennifer, Gastman, Brian R

“…IntroductionRadiation is an integral part of melanoma therapy, particularly for patients with symptomatic metastases. Efficient killing of tumor cells by…”
Get full text