Search Results - "Pfaffelhuber, P."

Fixation probabilities and hitting times for low levels of frequency-dependent selection by Pfaffelhuber, P., Wakolbinger, A.

“…In population genetics, diffusions on the unit interval are often used to model the frequency path of an allele. In this setting we derive approximations for…”
Get full text

The independent loss model with ordered insertions for the evolution of CRISPR spacers by Baumdicker, F., Huebner, A.M.I., Pfaffelhuber, P.

“…Today, the CRISPR (clustered regularly interspaced short palindromic repeats) region within bacterial and archaeal genomes is known to encode an adaptive…”
Get full text

Linkage Disequilibrium Under Genetic Hitchhiking in Finite Populations by Pfaffelhuber, P, Lehnert, A, Stephan, W

“…The model of genetic hitchhiking predicts a reduction in sequence diversity at a neutral locus closely linked to a beneficial allele. In addition, it has been…”
Get full text

Selective sweeps for recessive alleles and for other modes of dominance by Ewing, G., Hermisson, J., Pfaffelhuber, P., Rudolf, J.

“…A selective sweep describes the reduction of linked genetic variation due to strong positive selection. If s is the fitness advantage of a homozygote for the…”
Get full text

The tree length of an evolving coalescent by Pfaffelhuber, P., Wakolbinger, A., Weisshaupt, H.

“…A well-established model for the genealogy of a large population in equilibrium is Kingman’s coalescent. For the population together with its genealogy…”
Get full text

A Brownian ratchet for protein translocation including dissociation of ratcheting sites by Depperschmidt, A., Ketterer, N., Pfaffelhuber, P.

“…We study a model for the translocation of proteins across membranes through a nanopore using a ratcheting mechanism. When the protein enters the nanopore it…”
Get full text

THE DIVERSITY OF A DISTRIBUTED GENOME IN BACTERIAL POPULATIONS by Baumdicker, F., Hess, W. R., Pfaffelhuber, P.

“…The distributed genome hypothesis states that the set of genes in a population of bacteria is distributed over all individuals that belong to the specific…”
Get full text

The process of most recent common ancestors in an evolving coalescent by Pfaffelhuber, P., Wakolbinger, A.

“…Consider a haploid population which has evolved through an exchangeable reproduction dynamics, and in which all individuals alive at time t have a most recent…”
Get full text

MULLER'S RATCHET WITH COMPENSATORY MUTATIONS by Pfaffelhuber, P., Staab, P. R., Wakolbinger, A.

“…We consider an infinite-dimensional system of stochastic differential equations describing the evolution of type frequencies in a large population. The type of…”
Get full text

Approximating genealogies for partially linked neutral loci under a selective sweep by Pfaffelhuber, P, Studeny, A

“…Consider a genetic locus carrying a strongly beneficial allele which has recently fixed in a large population. As strongly beneficial alleles fix quickly,…”
Get full text

Approximate Genealogies Under Genetic Hitchhiking by Pfaffelhuber, P, Haubold, B, Wakolbinger, A

“…The rapid fixation of an advantageous allele leads to a reduction in linked neutral variation around the target of selection. The genealogy at a neutral locus…”
Get full text

Mean-field limits for non-linear Hawkes processes with excitation and inhibition by Pfaffelhuber, P., Rotter, S., Stiefel, J.

“…We study a multivariate, non-linear Hawkes process ZN on the complete graph with N nodes. Each vertex is either excitatory (probability p) or inhibitory…”
Get full text

Estimating mutation distances from unaligned genomes by Haubold, Bernhard, Pfaffelhuber, Peter, Domazet-Loso, Mirjana, Wiehe, Thomas

“…Abstract Alignment-free distance measures are generally less accurate but more efficient than traditional alignment-based metrics. In the context of genome…”
Get more information

Markov branching processes with disasters: extinction, survival and duality to p-jump processes by Hermann, F, Pfaffelhuber, P

“…A $p$-jump process is a piecewise deterministic Markov process with jumps by a factor of $p$. We prove a limit theorem for such processes on the unit interval…”
Get full text

94 IN SILICO MODELLING OF HUMAN LIPOPROTEIN METABOLISM by Jansen, M., Winkler, K., Pütz, G., Pfaffelhuber, P.

Get full text

Realistic extensions of a Brownian ratchet for protein translocation by Depperschmidt, A, Ketterer, N, Pfaffelhuber, P

“…We study a model for the translocation of proteins across membranes through a nanopore using a ratcheting mechanism. When the protein enters the nanopore it…”
Get full text

Approximating genealogies for partially linked neutral loci under a selective sweep by Pfaffelhuber, P, Studeny, A

“…Consider a genetic locus carrying a strongly beneficial allele which has recently fixed in a large population. As strongly beneficial alleles fix quickly,…”
Get full text

Muller's ratchet with compensatory mutations by Pfaffelhuber, P, Staab, P. R, Wakolbinger, A

“…Annals of Applied Probability 2012, Vol. 22, No. 5, 2108-2132 We consider an infinite-dimensional system of stochastic differential equations describing the…”
Get full text

The process of most recent common ancestors in an evolving coalescent by Pfaffelhuber, P, Wakolbinger, A

“…Consider a haploid population which has evolved through an exchangeable reproduction dynamics, and in which all individuals alive at time $t$ have a most…”
Get full text

The diversity of a distributed genome in bacterial populations by Baumdicker, F, Hess, W. R, Pfaffelhuber, P

“…Annals of Applied Probability 2010, Vol. 20, No. 5, 1567-1606 The distributed genome hypothesis states that the set of genes in a population of bacteria is…”
Get full text