Search Results - "Pezzoli, Suzan S"

Age-Dependent Decline in Acyl-Ghrelin Concentrations and Reduced Association of Acyl-Ghrelin and Growth Hormone in Healthy Older Adults by Nass, Ralf, Farhy, Leon S, Liu, Jianhua, Pezzoli, Suzan S, Johnson, Michael L, Gaylinn, Bruce D, Thorner, Michael O

“…Background: Acyl-ghrelin is thought to have both orexigenic effects and to stimulate GH release. A possible cause of the anorexia of aging is an age-dependent…”
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Evidence for Acyl-Ghrelin Modulation of Growth Hormone Release in the Fed State by Nass, Ralf, Farhy, Leon S., Liu, Jianhua, Prudom, Catherine E., Johnson, Michael L., Veldhuis, Paula, Pezzoli, Suzan S., Oliveri, Mary Clancy, Gaylinn, Bruce D., Geysen, H. Mario, Thorner, Michael O.

“…Context: The timing and frequency of GH secretory episodes is regulated by GHRH and somatostatin. This study provides evidence for amplification of these GH…”
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Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults : A Randomized Trial by NASS, Ralf, PEZZOLI, Suzan S, BLACKMAN, Marc R, CLANCY OLIVERI, Mary, PATRIE, James T, HARRELL, Frank E, CLASEY, Jody L, HEYMSFIELD, Steven B, BACH, Mark A, LEE VANCE, Mary, THORNER, Michael O

“…Growth hormone secretion and muscle mass decline from midpuberty throughout life, culminating in sarcopenia, frailty, decreased function, and loss of…”
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Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men by Liu, Jianhua, Prudom, Catherine E., Nass, Ralf, Pezzoli, Suzan S., Oliveri, Mary C., Johnson, Michael L., Veldhuis, Paula, Gordon, David A., Howard, Andrew D., Witcher, Derrick R., Geysen, H. Mario, Gaylinn, Bruce D., Thorner, Michael O.

“…Context: Ghrelin, an acylated peptide hormone secreted from the gut, regulates appetite and metabolism. Elucidating its pattern of secretion in the fed and…”
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The Level of Circulating Octanoate Does Not Predict Ghrelin O-Acyl Transferase (GOAT)-Mediated Acylation of Ghrelin During Fasting by Nass, Ralf, Nikolayev, Alexander, Liu, Jianhua, Pezzoli, Suzan S, Farhy, Leon S, Patrie, James, Gaylinn, Bruce D, Heiman, Mark, Thorner, Michael O

“…Background: Acyl-ghrelin is a 28-amino acid peptide released from the stomach. Ghrelin O-acyl transferase (GOAT) attaches an 8-carbon medium-chain fatty acid…”
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Four-Hour Infusion of Hydrocortisone Does Not Suppress the Nocturnal Increase of Circulating Acyl- or Desacyl-Ghrelin Concentrations in Healthy Young Adults by Nass, Ralf, Liu, Jianhua, Patrie, James, Pezzoli, Suzan S, Farhy, Leon S, Gaylinn, Bruce D, Thorner, Michael O

“…Background: Ghrelin is a 28-amino acid peptide released from the stomach. Ghrelin is found in the circulation in two forms: acyl- and desacyl-ghrelin. Acyl-…”
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Cranial Irradiation and Growth Hormone Neurosecretory Dysfunction: A Critical Appraisal by Darzy, Ken H., Pezzoli, Suzan S., Thorner, Michael O., Shalet, Stephen M.

“…Context: It has been suggested that radiation-induced GH neurosecretory dysfunction exists in children; however, the pathophysiology is poorly understood, and…”
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The Dynamics of Growth Hormone (GH) Secretion in Adult Cancer Survivors with Severe GH Deficiency Acquired after Brain Irradiation in Childhood for Nonpituitary Brain Tumors: Evidence for Preserved Pulsatility and Diurnal Variation with Increased Secretory Disorderliness by Darzy, Ken H., Pezzoli, Suzan S., Thorner, Michael O., Shalet, Stephen M.

“…Dynamics of GH secretion in patients with GH deficiency due to radiation damage of the hypothalamic-pituitary (h-p) axis acquired in childhood has rarely been…”
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The Impact of Short-Term Fasting on the Dynamics of 24-Hour Growth Hormone (GH) Secretion in Patients with Severe Radiation-Induced GH Deficiency by Darzy, Ken H., Murray, Robert D., Gleeson, Helena K., Pezzoli, Suzan S., Thorner, Michael O., Shalet, Stephen M.

“…Context: In patients with severe radiation-induced GH deficiency, we previously demonstrated that pulsatile GH secretion and diurnal rhythm are maintained in…”
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Pulsatile growth hormone secretion persists in genetic growth hormone-releasing hormone resistance by Maheshwari, Hiralal G, Pezzoli, Suzan S, Rahim, Asad, Shalet, Stephen M, Thorner, Michael O, Baumann, Gerhard

“…Growth hormone (GH) secretion is regulated by GH-releasing hormone (GHRH), somatostatin, and possibly ghrelin, but uncertainty remains about the relative…”
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IGF-I does not affect the net increase in GH release in response to arginine by Nass, Ralf, Pezzoli, Suzan S, Chapman, Ian M, Patrie, James, Hintz, Raymond L, Hartman, Mark L, Thorner, Michael O

“…Arginine stimulates growth hormone (GH) secretion, possibly by inhibiting hypothalamic somatostatin (SS) release. Insulin-like growth factor I (IGF-I) inhibits…”
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Preservation of Growth Hormone Pulsatility Despite Pituitary Pathology, Surgery, and Irradiation1 by Toogood, Andrew A, Nass, Ralf M, Pezzoli, Suzan S, O’Neill, Paul A, Thorner, Michael O, Shalet, Stephen M

“…Detailed assessment of physiological and pathophysiological GH secretion has, until recently, been limited by the poor sensitivity of the available assays. We…”
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Recovery of Growth Hormone Release from Suppression by Exogenous Insulin-Like Growth Factor I (IGF-I): Evidence for a Suppressive Action of Free Rather Than Bound IGF-I1 by Chapman, Ian M, Hartman, Mark L, Pieper, Karen S, Skiles, Emily H, Pezzoli, Suzan S, Hintz, Raymond L, Thorner, Michael O

“…To determine the time course of recovery of GH release from insulin-like growth factor I (IGF-I) suppression, 11 healthy adults (18–29 yr) received, in…”
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Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects by CHAPMAN, I. M, BACH, M. A, HARTMAN, M. L, VELDHUIS, J. D, GORMLEY, G. J, THORNER, M. O, VAN CAUTER, E, FARMER, M, KRUPA, D, TAYLOR, A. M, SCHILLING, L. M, COLE, K. Y, SKILES, E. H, PEZZOLI, S. S

“…Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular…”
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Both oral and transdermal estrogen increase growth hormone release in postmenopausal women : A clinical research center study by FRIEND, K. E, HARTMAN, M. L, PEZZOLI, S. S, CLASEY, J. L, THORNER, M. O

“…To determine if the mode of 17 beta-estradiol (E2) administration affects growth hormone (GH) concentrations, eight postmenopausal women were studied under the…”
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Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial by Nass, Ralf, Pezzoli, Suzan S., Oliveri, Mary Clancy, Patrie, James T., Harrell, Frank E., Clasey, Jody L., Heymsfield, Steven B., Bach, Mark A., Lee Vance, Mary, Thorner, Michael O.

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Growth hormone (gh) receptor blockade with a peg-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH by THORNER, M. O, STRASBURGER, C. J, WU, Z, STRAUME, M, BIDLINGMAIER, M, PEZZOLI, S. S, ZIB, K, SCARLETT, J. C, BENNETT, W. F

“…B2036-PEG, a GH receptor (GH-R) antagonist, is an analog of GH that is PEG-modified to prolong its action. Nine mutations alter the binding properties of this…”
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Recovery of growth hormone release from suppression by exogenous insulin-like growth factor I (IGF-I) : Evidence for a suppressive action of free rather than bound IGF-I by CHAPMAN, I. M, HARTMAN, M. L, PIEPER, K. S, SKILES, E. H, PEZZOLI, S. S, HINTZ, R. L, THORNER, M. O

“…To determine the time course of recovery of GH release from insulin-like growth factor I (IGF-I) suppression, 11 healthy adults (18-29 yr) received, in…”
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Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults by CHAPMAN, I. M, PESCOVITZ, O. H, THORNER, M. O, MURPHY, G, TREEP, T, CERCHIO, K. A, KRUPA, D, GERTZ, B, POLVINO, W. J, SKILES, E. H, PEZZOLI, S. S

“…To determine the effect of the GH releasing peptide (GHRP)-mimetic, MK-677, on the GH/insulin-like growth factor-I (IGF-I) axis in selected GH-deficient…”
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Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback by CHAPMAN, I. M, HARTMAN, M. L, PEZZOLI, S. S, HARRELL, F. E, HINTZ, R. L, ALBERTI, K. G. M. M, THORNER, M. O

“…To determine the effect of aging on the suppression of GH secretion by insulin-like growth factor (IGF)-I, we studied 11 healthy young adults (6 men, 5 women,…”
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