Search Results - "Pezet, Mikael G."

Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro by Pezet, Mikael G., Gomez-Duran, Aurora, Klimm, Florian, Aryaman, Juvid, Burr, Stephen, Wei, Wei, Saitou, Mitinori, Prudent, Julien, Chinnery, Patrick F.

“…Most humans carry a mixed population of mitochondrial DNA (mtDNA heteroplasmy) affecting ~1–2% of molecules, but rapid percentage shifts occur over one…”
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Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap by Gu, Jiacheng, Iyer, Abhishek, Wesley, Ben, Taglialatela, Angelo, Leuzzi, Giuseppe, Hangai, Sho, Decker, Aubrianna, Gu, Ruoyu, Klickstein, Naomi, Shuai, Yuanlong, Jankovic, Kristina, Parker-Burns, Lucy, Jin, Yinuo, Zhang, Jia Yi, Hong, Justin, Niu, Xiang, Costa, Jonathon A, Pezet, Mikael G, Chou, Jacqueline, Snoeck, Hans-Willem, Landau, Dan A, Azizi, Elham, Chan, Edmond M, Ciccia, Alberto, Gaublomme, Jellert T

“…Unlike sequencing-based methods, which require cell lysis, optical pooled genetic screens enable investigation of spatial phenotypes, including cell…”
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Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission by Zhang, Haixin, Esposito, Marco, Pezet, Mikael G, Aryaman, Juvid, Wei, Wei, Klimm, Florian, Calabrese, Claudia, Burr, Stephen P, Macabelli, Carolina H, Viscomi, Carlo, Saitou, Mitinori, Chiaratti, Marcos R, Stewart, James B, Jones, Nick, Chinnery, Patrick F

“…Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a few recurrent mutations account for the vast majority of new…”
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