Search Results - "Peyton, Michael"

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance by Wei, Yongjie, Zou, Zhongju, Becker, Nils, Anderson, Matthew, Sumpter, Rhea, Xiao, Guanghua, Kinch, Lisa, Koduru, Prasad, Christudass, Christhunesa S., Veltri, Robert W., Grishin, Nick V., Peyton, Michael, Minna, John, Bhagat, Govind, Levine, Beth

“…Cell surface growth factor receptors couple environmental cues to the regulation of cytoplasmic homeostatic processes, including autophagy, and aberrant…”
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells by Chen, Pei-Hsuan, Cai, Ling, Huffman, Kenneth, Yang, Chendong, Kim, Jiyeon, Faubert, Brandon, Boroughs, Lindsey, Ko, Bookyung, Sudderth, Jessica, McMillan, Elizabeth A., Girard, Luc, Chen, Dong, Peyton, Michael, Shields, Misty D., Yao, Bo, Shames, David S., Kim, Hyun Seok, Timmons, Brenda, Sekine, Ikuo, Britt, Rebecca, Weber, Stephanie, Byers, Lauren A., Heymach, John V., Chen, Jing, White, Michael A., Minna, John D., Xiao, Guanghua, DeBerardinis, Ralph J.

“…Intermediary metabolism in cancer cells is regulated by diverse cell-autonomous processes, including signal transduction and gene expression patterns, arising…”
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Improper data practices erode the quality of global ecological databases and impede the progress of ecological research by Augustine, Steven P., Bailey‐Marren, Isaac, Charton, Katherine T., Kiel, Nathan G., Peyton, Michael S.

“…The scientific community has entered an era of big data. However, with big data comes big responsibilities, and best practices for how data are contributed to…”
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Dietary Niche Variation in an Invasive Omnivore: The Effects of Habitat on Feral Pig Resource Use in Hawai'i by Peyton, Michael S, Kinney, Kealohanuiopuna M, Knox, Sarah, Tredennick, Grace, Hotchkiss, Sara

“…Invasive omnivores may have profound impacts on ecological communities through diet selection, particularly when their functional roles differ from those in…”
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Dietary Niche Variation in an Invasive Omnivore: The Effects of Habitat on Feral Pig Resource Use in Hawai‘i by Peyton, Michael S., Kinney, Kealohanuiopuna M., Knox, Sarah, Tredennick, Grace, Hotchkiss, Sara

“…ABSTRACT Invasive omnivores may have profound impacts on ecological communities through diet selection, particularly when their functional roles differ from…”
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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1 by Byers, Lauren Averett, Wang, Jing, Nilsson, Monique B, Fujimoto, Junya, Saintigny, Pierre, Yordy, John, Giri, Uma, Peyton, Michael, Fan, You Hong, Diao, Lixia, Masrorpour, Fatemeh, Shen, Li, Liu, Wenbin, Duchemann, Boris, Tumula, Praveen, Bhardwaj, Vikas, Welsh, James, Weber, Stephanie, Glisson, Bonnie S, Kalhor, Neda, Wistuba, Ignacio I, Girard, Luc, Lippman, Scott M, Mills, Gordon B, Coombes, Kevin R, Weinstein, John N, Minna, John D, Heymach, John V

“…Small cell lung cancer (SCLC) is an aggressive malignancy distinct from non-small cell lung cancer (NSCLC) in its metastatic potential and treatment response…”
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SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers by Tagal, Vural, Wei, Shuguang, Zhang, Wei, Brekken, Rolf A., Posner, Bruce A., Peyton, Michael, Girard, Luc, Hwang, TaeHyun, Wheeler, David A., Minna, John D., White, Michael A., Gazdar, Adi F., Roth, Michael G.

“…Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1) occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no…”
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Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors by Huang, Xiumei, Motea, Edward A., Moore, Zachary R., Yao, Jun, Dong, Ying, Chakrabarti, Gaurab, Kilgore, Jessica A., Silvers, Molly A., Patidar, Praveen L., Cholka, Agnieszka, Fattah, Farjana, Cha, Yoonjeong, Anderson, Glenda G., Kusko, Rebecca, Peyton, Michael, Yan, Jingsheng, Xie, Xian-Jin, Sarode, Venetia, Williams, Noelle S., Minna, John D., Beg, Muhammad, Gerber, David E., Bey, Erik A., Boothman, David A.

“…Therapeutic drugs that block DNA repair, including poly(ADP-ribose) polymerase (PARP) inhibitors, fail due to lack of tumor-selectivity. When PARP inhibitors…”
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Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression by Petersen, Sean L., Peyton, Michael, Minna, John D., Wang, Xiaodong

“…Smac mimetics target cancer cells in a TNFα-dependent manner, partly via proteasome degradation of cellular inhibitor of apoptosis 1 (cIAP1) and cIAP2…”
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PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR by SOS, Martin L, KOKER, Mirjam, MICHEL, Kathrin, PEIFER, Martin, MERMEL, Craig, GIRARD, Luc, PEYTON, Michael, GAZDAR, Adi F, MINNA, John D, GARRAWAY, Levi A, KASHKAR, Hamid, PAO, William, WEIR, Barbara A, MEYERSON, Matthew, THOMAS, Roman K, HEYNCK, Stefanie, RABINOVSKY, Rosalia, ZANDER, Thomas, SEEGER, Jens M, WEISS, Jonathan, FISCHER, Florian, FROMMOLT, Peter

“…Clinical resistance to epidermal growth factor receptor (EGFR) inhibition in lung cancer has been linked to the emergence of the EGFR T790M resistance mutation…”
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Synthetic lethal screen identification of chemosensitizer loci in cancer cells by Peyton, Michael, Bodemann, Brian O, Minna, John D, Hao, Weihua, Ferguson, Deborah, White, Michael A, Xie, Xian-Jin, Cardenas, Jessica, Roth, Michael G, Girard, Luc, Michnoff, Carolyn, Whitehurst, Angelique W

“…Abundant evidence suggests that a unifying principle governing the molecular pathology of cancer is the co-dependent aberrant regulation of core machinery…”
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PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis by Zhou, Xiaorong, Updegraff, Barrett L, Guo, Yabin, Peyton, Michael, Girard, Luc, Larsen, Jill E, Xie, Xian-Jin, Zhou, Yunyun, Hwang, Tae Hyun, Xie, Yang, Rodriguez-Canales, Jaime, Villalobos, Pamela, Behrens, Carmen, Wistuba, Ignacio I, Minna, John D, O'Donnell, Kathryn A

“…Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. Given the efficacy of membrane proteins as therapeutic targets…”
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SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function by McMahon, Kerrie-Ann, Zajicek, Hubert, Li, Wei-Ping, Peyton, Michael J, Minna, John D, Hernandez, V James, Luby-Phelps, Katherine, Anderson, Richard G W

“…Caveolae are a major membrane domain common to most cells. One of the defining features of this domain is the protein caveolin. The exact function of caveolin,…”
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Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance by Mender, Ilgen, LaRanger, Ryan, Luitel, Krishna, Peyton, Michael, Girard, Luc, Lai, Tsung-Po, Batten, Kimberly, Cornelius, Crystal, Dalvi, Maithili P., Ramirez, Michael, Du, Wenting, Wu, Lani F., Altschuler, Steven J., Brekken, Rolf, Martinez, Elisabeth D., Minna, John D., Wright, Woodring E., Shay, Jerry W.

“…Standard and targeted cancer therapies for late-stage cancer patients almost universally fail due to tumor heterogeneity/plasticity and intrinsic or acquired…”
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An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis by Hight, Suzie K., Mootz, Allison, Kollipara, Rahul K., McMillan, Elizabeth, Yenerall, Paul, Otaki, Yoichi, Li, Long-Shan, Avila, Kimberley, Peyton, Michael, Rodriguez-Canales, Jaime, Mino, Barbara, Villalobos, Pamela, Girard, Luc, Dospoy, Patrick, Larsen, Jill, White, Michael A., Heymach, John V., Wistuba, Ignacio I., Kittler, Ralf, Minna, John D.

“…Using a mini-library of 1062 lentiviral shRNAs targeting 40 nuclear hormone receptors and 70 of their co-regulators, we searched for potential therapeutic…”
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SLC43A3 Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2'-Deoxyguanosine by Mender, Ilgen, Batten, Kimberly, Peyton, Michael, Vemula, Aishwarya, Cornelius, Crystal, Girard, Luc, Gao, Boning, Minna, John D, Shay, Jerry W

“…Cell membrane transporters facilitate the passage of nucleobases and nucleosides for nucleotide synthesis and metabolism, and are important for the delivery of…”
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Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy by Sunaga, Noriaki, Shames, David S, Girard, Luc, Peyton, Michael, Larsen, Jill E, Imai, Hisao, Soh, Junichi, Sato, Mitsuo, Yanagitani, Noriko, Kaira, Kyoichi, Xie, Yang, Gazdar, Adi F, Mori, Masatomo, Minna, John D

“…Oncogenic KRAS is found in more than 25% of lung adenocarcinomas, the major histologic subtype of non-small cell lung cancer (NSCLC), and is an important…”
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Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo by Meng, Jieru, Dai, Bingbing, Fang, Bingliang, Bekele, B Nebiyou, Bornmann, William G, Sun, Duoli, Peng, Zhenghong, Herbst, Roy S, Papadimitrakopoulou, Vassiliki, Minna, John D, Peyton, Michael, Roth, Jack A

“…AZD6244 and MK2206 are targeted small-molecule drugs that inhibit MEK and AKT respectively. The efficacy of this combination in lung cancer is unknown. Our…”
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Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines by Gandhi, Jeet, Zhang, Jianling, Xie, Yang, Soh, Junichi, Shigematsu, Hisayuki, Zhang, Wei, Yamamoto, Hiromasa, Peyton, Michael, Girard, Luc, Lockwood, William W, Lam, Wan L, Varella-Garcia, Marileila, Minna, John D, Gazdar, Adi F

“…Deregulation of EGFR signaling is common in non-small cell lung cancers (NSCLC) and this finding led to the development of tyrosine kinase inhibitors (TKIs)…”
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STAT3 Mediates Resistance to MEK Inhibitor through MicroRNA miR-17 by BINGBING DAI, JIERU MENG, PEYTON, Michael, GIRARD, Luc, BORNMANN, William G, LIN JI, MINNA, John D, BINGLIANG FANG, ROTH, Jack A

“…AZD6244 is a small molecule inhibitor of the MEK (MAP/ERK kinase) pathway currently in clinical trials. However, the mechanisms mediating intrinsic resistance…”
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