Search Results - "Peyronnet, Emmanuel"

Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance by Urdy, Séverine, Hanke, Matthias, Toledo, Ana I., Ratto, Nicolas, Jacob, Evgueni, Peyronnet, Emmanuel, Gourlet, Jean-Baptiste, Chaves, Sandra S., Thommes, Edward, Coudeville, Laurent, Boissel, Jean-Pierre, Courcelles, Eulalie, Bruezière, Lara

“…Influenza vaccine effectiveness (VE) varies seasonally due to host, virus and vaccine characteristics. To investigate how antigenic matching and dosage impact…”
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Integration of Heterogeneous Biological Data in Multiscale Mechanistic Model Calibration: Application to Lung Adenocarcinoma by Palgen, Jean-Louis, Perrillat-Mercerot, Angélique, Ceres, Nicoletta, Peyronnet, Emmanuel, Coudron, Matthieu, Tixier, Eliott, Illigens, Ben M. W., Bosley, Jim, L’Hostis, Adèle, Monteiro, Claudio

“…Mechanistic models are built using knowledge as the primary information source, with well-established biological and physical laws determining the causal…”
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Knowledge-based mechanistic modeling accurately predicts disease progression with gefitinib in EGFR-mutant lung adenocarcinoma by L’Hostis, Adèle, Palgen, Jean-Louis, Perrillat-Mercerot, Angélique, Peyronnet, Emmanuel, Jacob, Evgueni, Bosley, James, Duruisseaux, Michaël, Toueg, Raphaël, Lefèvre, Lucile, Kahoul, Riad, Ceres, Nicoletta, Monteiro, Claudio

“…Lung adenocarcinoma (LUAD) is associated with a low survival rate at advanced stages. Although the development of targeted therapies has improved outcomes in…”
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Abstract 4139141: Predicted efficacy of inclisiran on cardiovascular outcomes in lower extremity peripheral artery disease: results of the In Silico Sirius study by Mahe, Guillaume, Angoulvant, Denis, Amarenco, Pierre, Bastien, Alexandre, Bechet, Emmanuelle, Boccara, Franck, Boissel, Jean-Pierre, Cariou, Bertrand, Courcelles, Eulalie, diatchenko, Alizee, Filipovics, Anne, Kahoul, Riad, Granjeon-Noriot, Solene, Peyronnet, Emmanuel, Portal, Lolita, Porte, Solene, Wang, Yishu, Steg, Philippe

“…Abstract only Introduction: Symptomatic lower extremity peripheral artery disease (PAD) patients have the highest risk of cardiovascular (CV) outcomes among…”
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Abstract 4134364: Predicted Low-Density Lipoprotein Cholesterol and Cardiovascular Outcomes Lowering With Inclisiran in Patients With or Without stroke: Insights from SIRIUS in silico trial by Amarenco, Pierre, Angoulvant, Denis, Bastien, Alexandre, Bechet, Emmanuelle, Boccara, Franck, Boissel, Jean-Pierre, Cariou, Bertrand, Courcelles, Eulalie, diatchenko, Alizee, Filipovics, Anne, Kahoul, Riad, Granjeon-Noriot, Solene, Mahe, Guillaume, Peyronnet, Emmanuel, Portal, Lolita, Porte, Solene, Wang, Yishu, Steg, Philippe

“…Abstract only Introduction: Inclisiran, an siRNA, targeting PCSK9 mRNA, reduces LDL-c levels. In SIRIUS in silico trial (NCT05974345), inclisiran was predicted…”
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Abstract 4139801: Predicted efficacy of Inclisiran compared to active comparators on Cardiovascular Outcomes in patients with established atherosclerotic cardiovascular disease: results from the In Silico SIRIUS trial by Cariou, Bertrand, Angoulvant, Denis, Amarenco, Pierre, Bastien, Alexandre, Bechet, Emmanuelle, Boissel, Jean-Pierre, Courcelles, Eulalie, Filipovics, Anne, Granjeon-Noriot, Solene, Kahoul, Riad, Mahe, Guillaume, Peyronnet, Emmanuel, Portal, Lolita, Wang, Yishu, Steg, Philippe, Boccara, Franck

“…Abstract only Background: Inclisiran, an siRNA targeting PCSK9 mRNA, administered twice-yearly, substantially and sustainably reduced LDL-C. Data quantifying…”
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Predicting the efficacy of inclisiran on cardiovascular outcomes in patients with established atherosclerotic cardiovascular disease: Primary results of the in silico SIRIUS trial by Angoulvant, Denis, Amarenco, Pierre, Bastien, Alexandre, Bechet, Emmanuelle, Boccara, Franck, Boissel, Jean-Pierre, Cariou, Bertrand, Courcelles, Eulalie, Diatchenko, Alizee, Filipovics, Anne, Granjeon-Noriot, Solene, Kahoul, Riad, Mahé, Guillaume, Peyronnet, Emmanuel, Portal, Lolita, Porte, Solène, Wang, Yishu, Steg, Philippe Gabriel

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Multiscale in silico knowledge-based model predicts tumor growth in advanced EGFR+ NSCLC patients on gefitinib by L'Hostis, Adèle, Palgen, Jean-Louis, Ceres, Nicoletta, Perrillat-Mercerot, Angelique, Peyronnet, Emmanuel, Jacob, Evgueni, Kahoul, Riad, Coudron, Matthieu, Lefevre, Lucile, Toueg, Raphael, Todea, Andreea, Hommel, Marc, Boissel, Jean-Pierre, Bosley, Jim, Duruisseaux, Michaël, Monteiro, Claudio

“…e20565 Background: Tumor heterogeneity and treatment resistance remains a continued threat to patients with advanced non-small cell lung cancer (NSCLC),…”
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In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme by Angoulvant, Denis, Granjeon-Noriot, Solène, Amarenco, Pierre, Bastien, Alexandre, Bechet, Emmanuelle, Boccara, Franck, Boissel, Jean-Pierre, Cariou, Bertrand, Courcelles, Eulalie, Diatchenko, Alizée, Filipovics, Anne, Kahoul, Riad, Mahé, Guillaume, Peyronnet, Emmanuel, Portal, Lolita, Porte, Solène, Wang, Yishu, Steg, Philippe Gabriel

“…Abstract Introduction Inclisiran, an siRNA targeting hepatic PCSK9 mRNA, administered twice-yearly (after initial and 3-month doses), substantially and…”
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Abstract 3362: Multiscale EGFR mutated NSCLC tumor heterogeneity knowledge-based model predicts tumor growth under gefitinib: An avenue to in silico clinical trial by Duruisseaux, Michael, L'Hostis, Adèle, Peyronnet, Emmanuel, Jacob, Evgueni, Illigens, Ben M.W., Bosley, Jim, Kahoul, Riad, Palgen, Jean-Louis, Monteiro, Claudio

“…Abstract Introduction: Non-small cell lung cancer (NSCLC) response to gefitinib depends on epidermal growth factor receptor (EGFR) mutational status. Response…”
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VALIDATION OF AN IN-SILICO KNOWLEDGE-BASED MECHANISTIC MODEL OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE FOR THE SIRIUS STUDY by Angoulvant, Denis, Amarenco, Pierre, BASTIEN, Alexandre, BECHET, Emmanuelle, Boccara, Franck, Boissel, Jean Pierre, Cariou, Bertrand, Courcelles, Eulalie, Diatchenko, Alizée, Granjeon-Noriot, Solene, Mahé, Guillaume, Peyronnet, Emmanuel, PORTAL, Lolita, Porte, Solène, Wang, Yishu, Steg, Philippe Gabriel

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